Naloxonazine
Encyclopedia
Naloxonazine is a potent irreversible mu opioid
antagonist
. Naloxonazine forms spontaneously in acidic solutions of naloxazone
, and may be responsible for much or all of the irreversible μ opioid receptor binding displayed by the latter.
Mu Opioid receptor
The μ-opioid receptors are a class of opioid receptors with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. They are also referred to as μ opioid peptide receptors. The prototypical μ receptor agonist is the opium alkaloid morphine; μ refers to morphine...
antagonist
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
. Naloxonazine forms spontaneously in acidic solutions of naloxazone
Naloxazone
Naloxazone is an irreversible μ opioid receptor antagonist which is selective for the μ1 receptor subtype. Naloxazone produces very long lasting antagonist effects as it forms a covalent bond to the active site of the mu-opioid receptor, thus making it impossible for the molecule to unbind and...
, and may be responsible for much or all of the irreversible μ opioid receptor binding displayed by the latter.
See also
- Oxymorphone-3-methoxynaltrexonazine (OM-3-MNZ) a similarly structured opioid also having two complete & mirrored morphinan carbon skeletons but which is a full agonist instead.