NSP5 (rotavirus)
Encyclopedia
NSP5 encoded by genome segment 11 of group A rotavirus
es. In virus-infected cells NSP5 accumulates in the viroplasm
s. NSP5 has been shown to be autophosphorylated.
Interaction of NSP5 with NSP2
was also demonstrated. In rotavirus
-infected cells, the non-structural proteins NSP5 and NSP2
localize in complexes called viroplasm
s, where replication and assembly occur and they can drive the formation of viroplasm-like structures in the absence of other rotaviral proteins and rotavirus replication.
Rotavirus
Rotavirus is the most common cause of severe diarrhoea among infants and young children, and is one of several viruses that cause infections often called stomach flu, despite having no relation to influenza. It is a genus of double-stranded RNA virus in the family Reoviridae. By the age of five,...
es. In virus-infected cells NSP5 accumulates in the viroplasm
Viroplasm
A viroplasm is an inclusion body in a cell where viral replication/assembly occurs. They may be thought of as viral factories in the cell. Very little is understood about the mechanism of viroplasm formation...
s. NSP5 has been shown to be autophosphorylated.
Interaction of NSP5 with NSP2
NSP2 (rotavirus)
NSP2, is a rotavirus nonstructural RNA-binding protein that accumulates in cytoplasmic inclusions and is required for genome replication. NSP2 is closely associated in vivo with the viral replicase. The non-structural protein NSP5 plays a role in the structure of viroplasms mediated by its...
was also demonstrated. In rotavirus
Rotavirus
Rotavirus is the most common cause of severe diarrhoea among infants and young children, and is one of several viruses that cause infections often called stomach flu, despite having no relation to influenza. It is a genus of double-stranded RNA virus in the family Reoviridae. By the age of five,...
-infected cells, the non-structural proteins NSP5 and NSP2
NSP2 (rotavirus)
NSP2, is a rotavirus nonstructural RNA-binding protein that accumulates in cytoplasmic inclusions and is required for genome replication. NSP2 is closely associated in vivo with the viral replicase. The non-structural protein NSP5 plays a role in the structure of viroplasms mediated by its...
localize in complexes called viroplasm
Viroplasm
A viroplasm is an inclusion body in a cell where viral replication/assembly occurs. They may be thought of as viral factories in the cell. Very little is understood about the mechanism of viroplasm formation...
s, where replication and assembly occur and they can drive the formation of viroplasm-like structures in the absence of other rotaviral proteins and rotavirus replication.