NSP2 (rotavirus)
Encyclopedia
NSP2, is a rotavirus
nonstructural RNA-binding protein
that accumulates in cytoplasmic inclusions (viroplasm
s) and is required for genome replication. NSP2 is closely associated in vivo with the viral replicase. The non-structural protein NSP5 plays a role in the structure of viroplasm
s mediated by its interaction with NSP2.
Rotavirus
Rotavirus is the most common cause of severe diarrhoea among infants and young children, and is one of several viruses that cause infections often called stomach flu, despite having no relation to influenza. It is a genus of double-stranded RNA virus in the family Reoviridae. By the age of five,...
nonstructural RNA-binding protein
RNA-binding protein
RNA-binding proteins are proteins that bind to RNA. They bind to either double-strand or single-strand RNAs through RNA recognition motif . RNA-binding proteins may regulate the translation of RNA, and post-transcriptional events, such as RNA splicing, editing.They are cytoplasmic and nuclear...
that accumulates in cytoplasmic inclusions (viroplasm
Viroplasm
A viroplasm is an inclusion body in a cell where viral replication/assembly occurs. They may be thought of as viral factories in the cell. Very little is understood about the mechanism of viroplasm formation...
s) and is required for genome replication. NSP2 is closely associated in vivo with the viral replicase. The non-structural protein NSP5 plays a role in the structure of viroplasm
Viroplasm
A viroplasm is an inclusion body in a cell where viral replication/assembly occurs. They may be thought of as viral factories in the cell. Very little is understood about the mechanism of viroplasm formation...
s mediated by its interaction with NSP2.