NIN (gene)
Encyclopedia
Ninein is a protein
that in humans is encoded by the NIN gene
. Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal
function. This protein is important for positioning and anchoring the microtubule
s minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zipper
s in the central coiled-coil domain. Multiple alternatively spliced
transcript variants that encode different isoforms have been reported.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the NIN gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal
Centrosome
In cell biology, the centrosome is an organelle that serves as the main microtubule organizing center of the animal cell as well as a regulator of cell-cycle progression. It was discovered by Edouard Van Beneden in 1883...
function. This protein is important for positioning and anchoring the microtubule
Microtubule
Microtubules are a component of the cytoskeleton. These rope-like polymers of tubulin can grow as long as 25 micrometers and are highly dynamic. The outer diameter of microtubule is about 25 nm. Microtubules are important for maintaining cell structure, providing platforms for intracellular...
s minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zipper
Leucine zipper
A leucine zipper, aka leucine scissors, is a common three-dimensional structural motif in proteins. These motifs are usually found as part of a DNA-binding domain in various transcription factors, and are therefore involved in regulating gene expression...
s in the central coiled-coil domain. Multiple alternatively spliced
Alternative splicing
Alternative splicing is a process by which the exons of the RNA produced by transcription of a gene are reconnected in multiple ways during RNA splicing...
transcript variants that encode different isoforms have been reported.