Myotubularin domain

Protein domain

A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...

 represents a region within eukaryotic myotubularin-related proteins that is sometimes found with . Myotubularin is a dual-specific lipid phosphatase

Phosphatase

A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group . This action is directly opposite to that of phosphorylases and kinases, which attach phosphate groups to their...

 that dephosphorylates phosphatidylinositol 3-phosphate

Phosphatidylinositol 3-phosphate

Phosphatidylinositol 3-phosphate is a phospholipid found in cell membranes that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes...

 and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.

Human proteins containing this domain

MTM1; MTMR1

MTMR1

Myotubularin-related protein 1 is a protein that in humans is encoded by the MTMR1 gene.-Further reading:...

; MTMR10; MTMR11; MTMR12; MTMR2

MTMR2

Myotubularin-related protein 2 is a protein that in humans is encoded by the MTMR2 gene.-External links:*...

; MTMR3

MTMR3

Myotubularin-related protein 3 is a protein that in humans is encoded by the MTMR3 gene.-References:...

; MTMR4;
MTMR6

MTMR6

Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene.-Further reading:...

; MTMR7; MTMR8; MTMR9

MTMR9

Myotubularin-related protein 9 is a protein that in humans is encoded by the MTMR9 gene.-Further reading:...

; SBF1

SBF1

Myotubularin-related protein 5 is a protein that in humans is encoded by the SBF1 gene.-Interactions:SBF1 has been shown to interact with MTMR2 and SUV39H1.-Further reading:...

; SBF2

SBF2

Myotubularin-related protein 13 is a protein that in humans is encoded by the SBF2 gene.-External links:*...

;

External links

- Myotubularin phosphatase domain in PROSITE

PROSITE

PROSITE is a protein database. It consists of entries describing the protein families, domains and functional sites as well as amino acid patterns, signatures, and profiles in them. These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot...