Multiple birth
Overview
A multiple birth occurs when more than one fetus
Fetus
A fetus is a developing mammal or other viviparous vertebrate after the embryonic stage and before birth.In humans, the fetal stage of prenatal development starts at the beginning of the 11th week in gestational age, which is the 9th week after fertilization.-Etymology and spelling variations:The...

 is carried to term in a single pregnancy
Pregnancy
Pregnancy refers to the fertilization and development of one or more offspring, known as a fetus or embryo, in a woman's uterus. In a pregnancy, there can be multiple gestations, as in the case of twins or triplets...

. Different names for multiple births are used, depending on the number of offspring. Common multiples are two and three, known as twins and triplets. These and other multiple births occur to varying degrees in most animal species, although the term is most applicable to placental
Eutheria
Eutheria is a group of mammals consisting of placental mammals plus all extinct mammals that are more closely related to living placentals than to living marsupials . They are distinguished from noneutherians by various features of the feet, ankles, jaws and teeth...

 species.

Multiple birth siblings are either monozygotic or dizygotic.
Encyclopedia
A multiple birth occurs when more than one fetus
Fetus
A fetus is a developing mammal or other viviparous vertebrate after the embryonic stage and before birth.In humans, the fetal stage of prenatal development starts at the beginning of the 11th week in gestational age, which is the 9th week after fertilization.-Etymology and spelling variations:The...

 is carried to term in a single pregnancy
Pregnancy
Pregnancy refers to the fertilization and development of one or more offspring, known as a fetus or embryo, in a woman's uterus. In a pregnancy, there can be multiple gestations, as in the case of twins or triplets...

. Different names for multiple births are used, depending on the number of offspring. Common multiples are two and three, known as twins and triplets. These and other multiple births occur to varying degrees in most animal species, although the term is most applicable to placental
Eutheria
Eutheria is a group of mammals consisting of placental mammals plus all extinct mammals that are more closely related to living placentals than to living marsupials . They are distinguished from noneutherians by various features of the feet, ankles, jaws and teeth...

 species.

Multiple birth siblings are either monozygotic or dizygotic. The former result from a single fertilized egg
Ovum
An ovum is a haploid female reproductive cell or gamete. Both animals and embryophytes have ova. The term ovule is used for the young ovum of an animal, as well as the plant structure that carries the female gametophyte and egg cell and develops into a seed after fertilization...

 or zygote
Zygote
A zygote , or zygocyte, is the initial cell formed when two gamete cells are joined by means of sexual reproduction. In multicellular organisms, it is the earliest developmental stage of the embryo...

 splitting into two or more embryos, each carrying the same genetic material(genes). Siblings created from one egg are commonly called identical. Since identical multiples share the same genetic material, they are almost always the same sex. Dizygotic or fraternal multiples instead result from multiple ova being ripened and released in the same menstrual cycle by a woman's ovaries, which are then fertilized to grow into multiples no more genetically alike than ordinary full siblings. Multiples called polyzygotic represent some combination of fraternal and identical siblings. For example, a set of triplets may be composed of identical twins from one egg and a third sibling from a second egg.

The most common form of multiple births for humans is twins. Many placental species give birth to multiples as a matter of course, with the resulting group called a litter
Litter (animal)
A litter is the offspring at one birth of animals from the same mother and usually from one set of parents. The word is most often used for the offspring of mammals, but can be used for any animal that gives birth to multiple young. In comparison, a group of eggs and the offspring that hatch from...

.

Terminology

  • Monozygotic – multiple (typically two) fetuses produced by the splitting of a single zygote
    Zygote
    A zygote , or zygocyte, is the initial cell formed when two gamete cells are joined by means of sexual reproduction. In multicellular organisms, it is the earliest developmental stage of the embryo...

  • Dizygotic – multiple (typically two) fetuses produced by two zygotes
  • Polyzygotic – multiple fetuses produced by two or more zygotes


Terms used for the order of multiple births in human beings are largely derived from the Latin
Latin
Latin is an Italic language originally spoken in Latium and Ancient Rome. It, along with most European languages, is a descendant of the ancient Proto-Indo-European language. Although it is considered a dead language, a number of scholars and members of the Christian clergy speak it fluently, and...

 names for numbers. Two offspring (twins) is the most common form, eight (octuplets) is the largest number ever successfully carried to full term with all children surviving.
  • Two offspring – twins
  • Three offspring – triplets
  • Four offspring – quadruplets
  • Five offspring – quintuplets
  • Six offspring – sextuplets
  • Seven offspring – septuplets
  • Eight offspring – octuplets
  • Nine offspring – nonuplets
  • Ten offspring – decaplets
  • Eleven offspring – undecaplets
  • Twelve offspring – duodecaplets
  • Thirteen offspring – tridecaplets
  • Fourteen offspring – quadecaplets
  • Fifteen offspring – quindecaplets
  • Sixteen offspring – sexdecuplets
  • Seventeen offspring – sepdecuplets
  • Eighteen offspring – octdecuplets
  • Nineteen offspring – nondecuplets
  • Twenty offspring – icosuplets

Higher order multiples

High orders of multiple births (three or more offspring in one birth) may result in a combination of fraternal (genetically different) and identical (genetically identical) siblings. The latter are also called super twins. For example, a set of quadruplets may consist of two sets of identical twins; in such a case each child has one identical and two fraternal siblings. This happens when multiple eggs are fertilized and one or more these subsequently divides into two fetuses. By analogy with monozygotic and dizygotic twins, such a combination is called dizygotic triplets. The Kübler triplets (see Elisabeth Kübler-Ross
Elisabeth Kübler-Ross
Elisabeth Kübler-Ross, M.D. was a Swiss American psychiatrist, a pioneer in Near-death studies and the author of the groundbreaking book On Death and Dying , where she first discussed what is now known as the Kübler-Ross model.She is a 2007 inductee into the American National Women's Hall of Fame...

) were of this type.

Identical triplets or quadruplets are very rare and result when the original fertilized egg splits and then one of the resultant cells splits again (for triplets) or, even more rarely, a further split occurs (for quadruplets). Alternatively the original fertilized egg can split twice (to produce four embryos) and all four may survive, to produce identical quadruplets, or one of the embryos may not survive and result in triplets.

Human multiple births

Twins are by far the most common multiples born live. Multiple births of as many as eight babies have been born alive, the first set on record to the Chukwu family
Chukwu octuplets
The Chukwu octuplets were the first set of octuplets live-born in the United States.-Family history:The six girls and two boys were born in December 1998 at St. Luke's Episcopal Hospital in Houston, Texas. Their parents — mother, Nkem Chukwu, then 27, and father, Iyke Louis Udobi, then 41 — were...

 in Texas in 1998; one died and seven survived. In 2009, a second set, the Suleman octuplets
Suleman octuplets
The Suleman octuplets are six male and two female children conceived via in vitro fertilization and subsequently born to Nadya Suleman on January 26, 2009, in Bellflower, California. They presently reside in La Habra, California...

, was born in Bellflower, California
Bellflower, California
Bellflower is a city in Los Angeles County, California, and is a suburb of Los Angeles. It was incorporated on September 3, 1957. As of the 2010 census, the city had a total population of 76,616, up from 72,878 at the 2000 census....

. To date, all eight have survived.

There have been a few sets of nonuplets (nine) in which a few babies were born alive, though none lived longer than a few days. There have been cases of human pregnancies that started out with ten, eleven, twelve or fifteen fetuses, but no instances of live births. The pregnancies of the 10, 11 and 15 fetuses have all resulted from fertility medication
Fertility medication
Fertility medication are drugs which enhance reproductive fertility. For women, fertility medication is used to stimulate follicle development of the ovary...

s and assisted reproductive technology (ART)
Assisted reproductive technology
Assisted reproductive technology is a general term referring to methods used to achieve pregnancy by artificial or partially artificial means. It is reproductive technology used primarily in infertility treatments. Some forms of ART are also used in fertile couples for genetic reasons...

. However there has been one documented case when 12 fetuses were conceived naturally.

Multiple pregnancies in humans are usually born prior to 38 weeks of gestation , the average length of pregnancy. Thirty-six weeks is average for twin births, thirty-two weeks for triplets and thirty weeks for quadruplets.

Quadruplets

Quadruplets result from the rare occurrence when four eggs are released and fertilized at once, or when one egg splits into four, or one egg splits into three with the fourth one fertilized, two eggs split into two, or one egg splits and two are fertilized.
One famous set of quadruplets includes the Genain quadruplets
Genain quadruplets
The Genain quadruplets are a set of identical quadruplet sisters notable for all having schizophrenia, suggesting a large genetic component to the cause of the disease. The fictitious name Genain, used to protect the identity of the family, comes from the Greek, meaning dire birth ...

 who were identical quadruplets who all developed schizophrenia.

Causes and frequency

According to Hellin's Law
Hellin's Law
Hellin's Law is the principle that one in about 89 pregnancies ends in the birth of twins, triplets once in 892 births, and quadruplets once in 893 births....

, multiple births occur naturally at approximately the rate of:
  • Twins: 1/89 (about 1.1%) of singleton births,
  • Triplets: 1/892 = 1/7921 (about 0.013%) of singleton births, and
  • N-tuplets: 1/89N-1 (app. 0.000142% for quadruplets, i.e. fewer than 1 quadruplet per 700,000 singleton births; even lower for higher N-tuplets)


North American dizygotic twinning occurs about once in 83 conceptions, and triplets about once in 8000 conceptions. In the US, there were over 136,000 multiple human births in 2003. A traditional approximation of the incidence of multiple pregnancies is as follows:
  • Twins 1:80
  • Triplets 1:80² = 1:6400
  • N-tuplets 1:80N-1


Human multiple births can occur either naturally (the woman ovulates multiple eggs or the fertilized egg splits into two) or as the result of infertility
Infertility
Infertility primarily refers to the biological inability of a person to contribute to conception. Infertility may also refer to the state of a woman who is unable to carry a pregnancy to full term...

 treatments such as IVF (several embryos are often transferred to compensate for lower quality) or fertility drugs (which can cause multiple eggs to mature in one ovulatory cycle).

For reasons that are not yet known, the older a woman is, the more likely she is to have a multiple birth naturally. It is theorized that this is due to the higher level of follicle-stimulating hormone
Follicle-stimulating hormone
Follicle-stimulating hormone is a hormone found in humans and other animals. It is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation, and reproductive processes of the body. FSH and Luteinizing hormone act...

 that older women sometimes have as their ovaries respond more slowly to FSH stimulation.

The number of multiple births has increased over the last decades. For example, in Canada between 1979 and 1999 the number of multiple birth babies increased 35%. Before the advent of ovulation-stimulating drugs, triplets were quite rare (approximately 1 in 8000 births) and higher order births much rarer still. Much of the increase can probably be attributed to the impact of fertility treatments, such as in-vitro fertilization. Younger patients who undergo treatment with fertility medication
Fertility medication
Fertility medication are drugs which enhance reproductive fertility. For women, fertility medication is used to stimulate follicle development of the ovary...

 containing artificial FSH
FSH
FSH may refer to:* Follicle-stimulating hormone* Fox Sports Houston, a regional Fox Sports Net affiliate station for the Houston, Texas area* Facioscapulohumeral muscular dystrophy* International Civil Aviation Organisation code for Flash Airlines...

, followed by intrauterine insemination
Insemination
Insemination is the deliberate introduction of sperm into the uterus of a mammal or the oviduct of an oviparous animal for the objective of impregnating a female for reproduction...

, are particularly at risk for multiple births of higher order.
Certain factors appear to increase the likelihood that a woman will naturally conceive multiples. These include:
  • mother's age — women over 35 are more likely to have multiples than younger women
  • mother's use of fertility drugs — approximately 35% of pregnancies arising through the use of fertility treatments such as IVF involve more than one child


The increasing use of fertility drugs and consequent increased rate of multiple births has made the phenomenon of multiples increasingly visible in the public eye. In 2004, the birth of sextuplets to Pennsylvania couple Kate and Jon Gosselin helped them to launch their own highly popular television series, originally Jon & Kate Plus 8 and now (following their divorce) Kate Plus 8, which is the highest rated show on the TLC
TLC (TV channel)
TLC is an American cable TV specialty channel which initially focused on educational content. Since 1991 TLC has been owned by Discovery Communications, the same company that operates the Discovery Channel, Animal Planet and The Science Channel, as well as other learning-themed networks...

network.

Premature birth and low birth weight

Babies born from multiple-birth pregnancies are more likely to result in premature birth
Premature birth
In humans preterm birth refers to the birth of a baby of less than 37 weeks gestational age. The cause for preterm birth is in many situations elusive and unknown; many factors appear to be associated with the development of preterm birth, making the reduction of preterm birth a challenging...

 than those from single pregnancies. 51% of twins and 91% of triplets are born preterm, compared to 9.4% in singletons. 14% of twins and 41% of triplets are even born very preterm, compared to 1.7% in singletons.

The preterm births also result in multiples tending to have a lower birth weight compared to singletons.

Some evidence indicates that only 1.10% of singletons are born with a very low birth weight and 10.12% twins and 31.88% triplets were found to be born with very low birth weight. This Study was conducted by looking at the statistics from the U.S. Natality Files (5).

Among the exceptions are the Kupresak triplets of Mississauga, Ontario
Ontario
Ontario is a province of Canada, located in east-central Canada. It is Canada's most populous province and second largest in total area. It is home to the nation's most populous city, Toronto, and the nation's capital, Ottawa....

, Canada
Canada
Canada is a North American country consisting of ten provinces and three territories. Located in the northern part of the continent, it extends from the Atlantic Ocean in the east to the Pacific Ocean in the west, and northward into the Arctic Ocean...

; their combined weight at birth in 2008, of 17 lbs, 2.7 ounces, set a world record.

Cerebral palsy

Cerebral palsy
Cerebral palsy
Cerebral palsy is an umbrella term encompassing a group of non-progressive, non-contagious motor conditions that cause physical disability in human development, chiefly in the various areas of body movement....

 is more common among multiple births than single births, being 2.3 per 1,000 survivors in singletons, 13 in twins, and 45 in triplets in North West England
North West England
North West England, informally known as The North West, is one of the nine official regions of England.North West England had a 2006 estimated population of 6,853,201 the third most populated region after London and the South East...

.

Incomplete separation

Multiples may become monochorionic, sharing the same chorion
Chorion
The chorion is one of the membranes that exist during pregnancy between the developing fetus and mother. It is formed by extraembryonic mesoderm and the two layers of trophoblast and surrounds the embryo and other membranes...

, with resultant risk of twin-to-twin transfusion syndrome
Twin-to-twin transfusion syndrome
Twin-to-twin transfusion syndrome is a complication of disproportionate blood supply, resulting in high morbidity and mortality. It can affect monochorionic multiples, that is multiple pregnancies where two or more fetuses share a chorion and hence a single placenta...

. Monochorionic multiples may even become monoamniotic, sharing the same amniotic sac
Amniotic sac
The amniotic sac is the sac in which the fetus develops in amniotes. It is a tough but thin transparent pair of membranes, which hold a developing embryo until shortly before birth. The inner membrane, the amnion, contains the amniotic fluid and the fetus. The outer membrane, the Chorion,...

, resulting in risk of umbilical cord compression and entanglement. In very rare cases, there may be conjoined twins
Conjoined twins
Conjoined twins are identical twins whose bodies are joined in utero. A rare phenomenon, the occurrence is estimated to range from 1 in 50,000 births to 1 in 100,000 births, with a somewhat higher incidence in Southwest Asia and Africa. Approximately half are stillborn, and a smaller fraction of...

, possibly impairing function of internal organs.

Mortality rate (stillbirth)

Multiples are also known to have a higher mortality rate. It is more common for multiple births to be stillborn, while for singletons the risk is not as high. A literary review on multiple pregnancies shows a study done on one set each of septuplets and octuplets, two sets of sextuplets, 8 sets of quintuplets, 17 sets of quadruplets, and 228 sets of triplets. By doing this study, Hammond found that the mean gestational age (how many weeks when birthed) at birth was 33.4 weeks for triplets and 31 weeks for quadruplets. This shows that stillbirth happens usually 3–5 weeks before the woman reaches full term and also that for sextuplets or higher it almost always ends in death of the fetuses.
Though multiples are at a greater risk of being stillborn, there is inconclusive evidence whether the actual mortality rate is higher in multiples than in singletons.

Fertility therapy problems and selective reduction

Today many multiple pregnancies are the result of fertility therapy. Elsner studied 42 months of IVF (in vitro fertilization) procedures, and related the number of embryos transferred and the pregnancy outcome. In this time, they found that of the 2,173 embryo transfers performed, 734 were successfully delivered pregnancies (33.8%). These were analyzed…the overall multiple pregnancy rate was 31.3% (24.7% twins, 5.8% triplets, and .08% quadruplets). This evidence shows that almost all of the births delivered were multiples rather than singletons. Because IVFs are producing more multiples, a number of efforts are being made to reduce the risk of multiple births- specifically triplets or more. Medical practitioners are doing this by limiting the number of embryos per embryo transfer to one or two. That way, the risks for the mother and fetuses are decreased. De Sutter found by looking at a previous study done in 1997, that by using SET (single embryo transfer) the twin birth rate dropped from 30% to 21%. Sutter also found that the use of this transfer method increased from 1.5% to 17.5%. So limiting the number of embryos transferred can reduce the risks of having multiples and so reduce the risks associated with multiple pregnancies.

Another procedure that the medical world is using today is known as selective reduction
Abortion
Abortion is defined as the termination of pregnancy by the removal or expulsion from the uterus of a fetus or embryo prior to viability. An abortion can occur spontaneously, in which case it is usually called a miscarriage, or it can be purposely induced...

, i.e. the termination of one or more, but not all, of the fetuses. This is often done in pregnancies with multiple gestations to increase the likelihood that one child may live a healthy life. Armour found by looking at a review of a series of 1,000 selective reduction cases, there has had a loss rate of 5.4% in pregnancies. Many of the losses (15%) occurred within 4 weeks of the procedures and more than 50% occurred after 8 weeks. This suggests that the reduction was successful at reducing the embryos from multiple gestations to single.

Though selective reduction seems to be working, mothers of multiples who undergo this procedure are at a higher risk of miscarrying compared to that of an unreduced multiple pregnancy. A study done by looking at 158 pregnant women who underwent selective reduction from higher order multiples to twins showed that the mother had a 10.6% chance of miscarriage. Mothers of twin pregnancies without reduction only had a 9.5% chance of miscarriage. Antsaklis shows that there is a small increase in mortality for reduced twin pregnancies versus unreduced twin pregnancies.

Competition among fertility clinics does not appear to increase rates of multiple births from fertility treatment by promoting more aggressive embryo transfer decisions.

Birthing process and neonatal intensive care

When it comes to the birthing process of multiples, mothers are more likely to receive a Caesarean (C-section) delivery than natural. Michael Kogan found that between 1989–1991 and 1995-1997 the cesarean delivery rate for mothers of multiples increased from 21.9% to 27%. Kogan discovered this evidence by looking at the National Center for Health Statistics, births and infant death records for twins in the United States.

Multiple-birth infants are usually admitted to neonatal intensive care immediately after being born. The records for all the triplet pregnancies managed and delivered from 1992-1996 were looked over to see what the neonatal statistics were. Kaufman found from reviewing these files that during a five year period, 55 triplet pregnancies, which is 165 babies, were delivered. Of the 165 babies 149 were admitted to neonatal intensive care after the delivery(90%).

Cultural aspects

Certain cultures consider multiple births a portent of either good or evil.

Mayan
Maya civilization
The Maya is a Mesoamerican civilization, noted for the only known fully developed written language of the pre-Columbian Americas, as well as for its art, architecture, and mathematical and astronomical systems. Initially established during the Pre-Classic period The Maya is a Mesoamerican...

 culture saw twins as a blessing, and was fascinated by the idea of two bodies looking alike. The Mayans used to believe that twins were one soul that had fragmented.

In Ancient Rome, the legend of the twin brothers who founded the city (Romulus and Remus
Romulus and Remus
Romulus and Remus are Rome's twin founders in its traditional foundation myth, although the former is sometimes said to be the sole founder...

) made the birth of twin boys a blessing, while twin girls were seen as an unlucky burden, since both would have to be provided with an expensive dowry
Dowry
A dowry is the money, goods, or estate that a woman brings forth to the marriage. It contrasts with bride price, which is paid to the bride's parents, and dower, which is property settled on the bride herself by the groom at the time of marriage. The same culture may simultaneously practice both...

 at about the same time.

In Greek mythology, fraternal twins Castor and Polydeuces, and Heracles and Iphicles
Heracles
Heracles ,born Alcaeus or Alcides , was a divine hero in Greek mythology, the son of Zeus and Alcmene, foster son of Amphitryon and great-grandson of Perseus...

, are sons of two different fathers. One of the twins (Polydeuces
Polydeuces
Polydeuces may refer to:*Polydeuces , a moon of Saturn*An alternative name for the Greek mythological hero Pollux...

, Heracles
Heracles
Heracles ,born Alcaeus or Alcides , was a divine hero in Greek mythology, the son of Zeus and Alcmene, foster son of Amphitryon and great-grandson of Perseus...

) is the illegitimate son of the god Zeus
Zeus
In the ancient Greek religion, Zeus was the "Father of Gods and men" who ruled the Olympians of Mount Olympus as a father ruled the family. He was the god of sky and thunder in Greek mythology. His Roman counterpart is Jupiter and his Etruscan counterpart is Tinia.Zeus was the child of Cronus...

; his brother is the son of their mother's mortal husband. A similar pair of twin sisters are Helen (of Troy) and Clytemnestra
Clytemnestra
Clytemnestra or Clytaemnestra , in ancient Greek legend, was the wife of Agamemnon, king of the Ancient Greek kingdom of Mycenae or Argos. In the Oresteia by Aeschylus, she was a femme fatale who murdered her husband, Agamemnon – said by Euripides to be her second husband – and the Trojan princess...

 (who are also sisters of Castor and Polydeuces). The theme occurs in other mythologies as well, and is called superfecundation.

In certain medieval European chivalric romances, such as Marie de France
Marie de France
Marie de France was a medieval poet who was probably born in France and lived in England during the late 12th century. She lived and wrote at an undisclosed court, but was almost certainly at least known about at the royal court of King Henry II of England...

's Le Fresne
Le Fresne (lai)
"Le Fresne" is one of the Lais of Marie de France. It was likely written in the late 12th century. As a Breton lai, it is an example of Anglo-Norman literature.-Plot summary:Le Fresne begins with two wedded knights...

, a woman cites a multiple birth (often to a lower-class woman) as proof of adultery on her part; while this may reflect a widespread belief, it is invariably treated as malicious slander, to be justly punished by the accuser having a multiple birth of her own, and the events of the romance are triggered by her attempt to hide one or more of the children. A similar effect occurs in the Knight of the Swan
Knight of the Swan
The story of the Knight of the Swan, or Swan Knight, is a medieval tale about a mysterious rescuer who comes in a swan-drawn boat to defend a damsel, his only condition being that he must never be asked his name...

 romance, in the Beatrix variants of the Swan-Children; her taunt is punished by giving birth to seven children at once, and her wicked mother-in-law returns her taunt before exposing the children.

See also

  • Only child
    Only child
    An only child is a person with no siblings, either biological or adopted. In a family with multiple offspring, first-borns, may be briefly considered only children and have a similar early family environment, but the term only child is generally applied only to those individuals who never have...

  • Biological reproduction
    Biological reproduction
    Reproduction is the biological process by which new "offspring" individual organisms are produced from their "parents". Reproduction is a fundamental feature of all known life; each individual organism exists as the result of reproduction...

  • Conjoined twins
    Conjoined twins
    Conjoined twins are identical twins whose bodies are joined in utero. A rare phenomenon, the occurrence is estimated to range from 1 in 50,000 births to 1 in 100,000 births, with a somewhat higher incidence in Southwest Asia and Africa. Approximately half are stillborn, and a smaller fraction of...

  • List of multiple births
  • List of twins
  • Twin
    Twin
    A twin is one of two offspring produced in the same pregnancy. Twins can either be monozygotic , meaning that they develop from one zygote that splits and forms two embryos, or dizygotic because they develop from two separate eggs that are fertilized by two separate sperm.In contrast, a fetus...

  • Feodor Vassilyev
    Feodor Vassilyev
    Feodor Vassilyev was a peasant from Shuya, Russia. His first wife, Mrs. Vassilyev sets the record for most children birthed by a single woman. She gave birth to a total of 69 children; however, few other details are known of her life, such as her date of birth or death...

  • Half a Dozen Babies
    Half a Dozen Babies
    Half a Dozen Babies is a 1999 American drama ABC Family TV film. It stars Scott and Melissa Reeves. It is rated TV-PG. The runtime is 89 mins. A young couple have been struggling to have a baby for years, unsuccessfully. Then, suddenly, one day, they find out that they are having sextuplets...

    a 1999 drama film, about the 1993 born Dilley sextuplets
    Dilley sextuplets
    The Dilley sextuplets are the United States' first set of sextuplets born to Becki and Keith Dilley in Indianapolis, Indiana, United States. They are, in birth order;* Brenna Rose* Julian Emerson* Quinn Everett* Claire Diane...

    .
  • Superfecundation
    Superfecundation
    Superfecundation is the fertilization of two or more ova from the same cycle by sperm from separate acts of sexual intercourse. The term superfecundation is derived from fecund, meaning the ability to produce offspring....

     (multiple pregnancy resulting from separate sexual intercourses)

External links

The source of this article is wikipedia, the free encyclopedia.  The text of this article is licensed under the GFDL.
 
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