Müller glia, or Müller cells, are glial cell

Glial cell

Glial cells, sometimes called neuroglia or simply glia , are non-neuronal cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the brain, and for neurons in other parts of the nervous system such as in the autonomous nervous system...

s found in the vertebrate

Vertebrate

Vertebrates are animals that are members of the subphylum Vertebrata . Vertebrates are the largest group of chordates, with currently about 58,000 species described. Vertebrates include the jawless fishes, bony fishes, sharks and rays, amphibians, reptiles, mammals, and birds...

 retina

Retina

The vertebrate retina is a light-sensitive tissue lining the inner surface of the eye. The optics of the eye create an image of the visual world on the retina, which serves much the same function as the film in a camera. Light striking the retina initiates a cascade of chemical and electrical...

, which normally serve the functions of any normal glial cells. However, following injury to the retina, it has been seen that Müller glia undergo dedifferentiation into multipotent progenitor cell

Progenitor cell

A progenitor cell is a biological cell that, like a stem cell, has a tendency to differentiate into a specific type of cell, but is already more specific than a stem cell and is pushed to differentiate into its "target" cell...

s. At this point, the progenitor cell can divide and differentiate

Cellular differentiation

In developmental biology, cellular differentiation is the process by which a less specialized cell becomes a more specialized cell type. Differentiation occurs numerous times during the development of a multicellular organism as the organism changes from a simple zygote to a complex system of...

 into a number of retinal cell types, including photoreceptor cells, that may have been damaged during injury. Additionally, recently published research has shown that Müller cells act as a light collector in the mammal

Mammal

Mammals are members of a class of air-breathing vertebrate animals characterised by the possession of endothermy, hair, three middle ear bones, and mammary glands functional in mothers with young...

ian eye, analogous to a fiber optic plate, funneling light to the rod

Rod cell

Rod cells, or rods, are photoreceptor cells in the retina of the eye that can function in less intense light than can the other type of visual photoreceptor, cone cells. Named for their cylindrical shape, rods are concentrated at the outer edges of the retina and are used in peripheral vision. On...

 and cone

Cone cell

Cone cells, or cones, are photoreceptor cells in the retina of the eye that are responsible for color vision; they function best in relatively bright light, as opposed to rod cells that work better in dim light. If the retina is exposed to an intense visual stimulus, a negative afterimage will be...

 cells.

Research Potential

Müller glia are currently being studied for their role in neural regeneration, a phenomenon that is not known to occur in humans. Published papers have studied Müller glia in both zebrafish and chicken retina, and further research could help towards solutions for the blind or visually impaired.

External links

• New Hope For Regenerating Damaged Human Retina: Sleeping Stem Cells Successfully Awakened
• Müller cells at Virginia-Maryland Regional College of Veterinary Medicine
  Virginia-Maryland Regional College of Veterinary Medicine
  The Virginia-Maryland Regional College of Veterinary Medicine is a state-supported college of two states, Virginia and Maryland, filling the need for veterinary medicine education in both states. Students from both states are considered "in-state" students for admissions purposes.VMRCVM is one of...
  
  
• NIF Search - Muller Cell via the Neuroscience Information Framework
  Neuroscience Information Framework
  The Neuroscience Information Framework is a repository of global neuroscience web resources, including experimental, clinical, and translational neuroscience databases, knowledge bases, atlases, and genetic/genomic resources.-Description:...