Mucoid plaque
Encyclopedia
Mucoid plaque or mucoid rope is a term used by some alternative medicine
Alternative medicine
Alternative medicine is any healing practice, "that does not fall within the realm of conventional medicine." It is based on historical or cultural traditions, rather than on scientific evidence....

 advocates to describe a combination of allegedly harmful mucus-like
Mucus
In vertebrates, mucus is a slippery secretion produced by, and covering, mucous membranes. Mucous fluid is typically produced from mucous cells found in mucous glands. Mucous cells secrete products that are rich in glycoproteins and water. Mucous fluid may also originate from mixed glands, which...

 material and food residue that they say coats the gastrointestinal tract
Gastrointestinal tract
The human gastrointestinal tract refers to the stomach and intestine, and sometimes to all the structures from the mouth to the anus. ....

 of most people. The term was coined by Richard Anderson, a naturopath and entrepreneur
Entrepreneur
An entrepreneur is an owner or manager of a business enterprise who makes money through risk and initiative.The term was originally a loanword from French and was first defined by the Irish-French economist Richard Cantillon. Entrepreneur in English is a term applied to a person who is willing to...

, who sells a range of products that claim to cleanse the body of such plaques by causing them to be eliminated. Many such "colon cleansing" products are promoted to the public on websites that have been described as making misleading medical claims. The presence of laxatives, clay, and fibrous thickening agents in some of these "cleansing agents" have led to suggestions that the products themselves produce the excreted product regarded as the plaque.

Mucus is a naturally occurring product of the digestive system and plays an important role in protecting it from damage and infection. This mucus layer is less than a millimetre thick, but may become thinner or be removed entirely in diseases such as ulcerative colitis
Ulcerative colitis
Ulcerative colitis is a form of inflammatory bowel disease . Ulcerative colitis is a form of colitis, a disease of the colon , that includes characteristic ulcers, or open sores. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset...

, which exposes the surface of the intestine to damage. However, the concept that this mucus layer might form a 'mucoid plaque' has been dismissed by physician
Physician
A physician is a health care provider who practices the profession of medicine, which is concerned with promoting, maintaining or restoring human health through the study, diagnosis, and treatment of disease, injury and other physical and mental impairments...

s as having no anatomical or physiological basis.

History

Various forms of colon cleansing were popular in the 19th and early 20th century. In 1932, Bastedo wrote in the Journal of the American Medical Association
Journal of the American Medical Association
The Journal of the American Medical Association is a weekly, peer-reviewed, medical journal, published by the American Medical Association. Beginning in July 2011, the editor in chief will be Howard C. Bauchner, vice chairman of pediatrics at Boston University’s School of Medicine, replacing ...

 about his observation of mucus masses being removed by a colon irrigation procedure: "When one sees the dirty gray, brown or blackish sheets, strings and rolled up wormlike masses of tough mucus with a rotten or dead-fish odor that are obtained by colon irrigations, one does not wonder that these patients feel ill and that they obtain relief and show improvement as the result of the irrigation."

While colonic irrigation enjoyed a vogue in early 20th century as a possible cure for numerous diseases, subsequent research showed that it was useless and potentially harmful. With the scientific rationale for "colon cleansing" disproven, the idea fell into disrepute as a form of quackery
Quackery
Quackery is a derogatory term used to describe the promotion of unproven or fraudulent medical practices. Random House Dictionary describes a "quack" as a "fraudulent or ignorant pretender to medical skill" or "a person who pretends, professionally or publicly, to have skill, knowledge, or...

, with a recent medical review stating that "there is no evidence to support this ill-conceived theory that has been long abandoned by the scientific community." Similarly, in response to claims that colon cleansing removes "toxins" Bennett Roth, a gastroenterologist at the University of California
University of California, Los Angeles
The University of California, Los Angeles is a public research university located in the Westwood neighborhood of Los Angeles, California, USA. It was founded in 1919 as the "Southern Branch" of the University of California and is the second oldest of the ten campuses...

 stated "There is absolutely no science to this whatsoever. There is no such thing as getting rid of quote-unquote 'toxins.' The colon was made to carry stool. This is total baloney." The preoccupation with such bowel management products has been described as a "quaint and amusing chapter in the history of weird medical beliefs." Nevertheless, interest in colonic "autointoxication" as a cause of illness, and in colonic irrigation as a cure, enjoyed a revival in alternative medicine
Alternative medicine
Alternative medicine is any healing practice, "that does not fall within the realm of conventional medicine." It is based on historical or cultural traditions, rather than on scientific evidence....

 at the end of the 20th century.

The term "mucoid plaque" was coined and popularized by naturopath Richard Anderson. However, Anderson acknowledges that a similar concept has been described previously by practitioners of alternative medicine. Victor Earl Irons and Bernard Jensen
Bernard Jensen
Bernard Jensen was a chiropractor, entrepreneur, and the author of numerous books and articles on health and healing....

 used the terms "toxic mucous lining" or "toxic mucous layer" in their books. Robert Gray referred to "mucoid matter" in his 1990 book on colon health.

Statements by Anderson

Anderson describes a mucoid plaque as a rubbery, ropey, generally green gel
Gel
A gel is a solid, jelly-like material that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state...

-like mucus film that covers the epithelial cells of the hollow organs
Lumen (anatomy)
A lumen in biology is the inside space of a tubular structure, such as an artery or intestine...

, particularly of the alimentary canal. Anderson also claims the plaque can impair digestion and the absorption of nutrients, hold pathogen
Pathogen
A pathogen gignomai "I give birth to") or infectious agent — colloquially, a germ — is a microbe or microorganism such as a virus, bacterium, prion, or fungus that causes disease in its animal or plant host...

s, and cause illnesses such as diarrhea
Diarrhea
Diarrhea , also spelled diarrhoea, is the condition of having three or more loose or liquid bowel movements per day. It is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause dehydration and...

, bowel cancer, allergies and skin conditions. Based on these claims, he promotes efforts to remove the plaque, and sells a range of products to this end.

Though Anderson states his beliefs are backed by scientific research, his claims are primarily supported by anecdotal evidence
Anecdotal evidence
The expression anecdotal evidence refers to evidence from anecdotes. Because of the small sample, there is a larger chance that it may be true but unreliable due to cherry-picked or otherwise unrepresentative of typical cases....

 rather than empirical data and doctors have failed to note the existence of mucoid plaques. Anderson claims this is due to medical textbooks failing to cover the concept and therefore doctors not knowing what to look for.

Medical evaluation

Practicing physician
Physician
A physician is a health care provider who practices the profession of medicine, which is concerned with promoting, maintaining or restoring human health through the study, diagnosis, and treatment of disease, injury and other physical and mental impairments...

s have dismissed the concept of mucoid plaque as a hoax
Hoax
A hoax is a deliberately fabricated falsehood made to masquerade as truth. It is distinguishable from errors in observation or judgment, or rumors, urban legends, pseudosciences or April Fools' Day events that are passed along in good faith by believers or as jokes.-Definition:The British...

 and a "non-credible concept". A pathologist at the University of Texas School of Medicine addressed Anderson's claims directly, saying that he has "seen several thousand intestinal biopsies and have never seen any 'mucoid plaque.' This is a complete fabrication with no anatomic basis." Another pathologist, Edward Friedlander, has noted during his experience that he has never observed anything resembling a "toxic bowel settlement" and that some online photographs actually depict what he recognises as a blood clot
Melena
In medicine, melena or melaena refers to the black, "tarry" feces that are associated with gastrointestinal hemorrhage. The black color is caused by oxidation of the iron in hemoglobin during its passage through the ileum and colon.-Melena vs...

. Commenting on claims that waste material can adhere to the colon, Douglas Pleskow, a gastroenterologist at Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center in Boston, Massachusetts is a major flagship teaching hospital of Harvard Medical School. It was formed out of the 1996 merger of Beth Israel Hospital and New England Deaconess Hospital...

, stated "That is the urban legend. In reality, most people clear their GI tract within three days."

In a review of websites promoting products that claim to remove 'mucoid rope' or plaque from consumers' intestines, Howard Hochster of New York University
New York University
New York University is a private, nonsectarian research university based in New York City. NYU's main campus is situated in the Greenwich Village section of Manhattan...

 wrote that these websites are "abundant, quasi-scientific, and unfortunately convincing to a biologically uneducated public." He noted that although such sites are entertaining, they are disturbing in that they promote a belief that has no basis in physiology. Hochster also noted that a preparation marketed to remove mucoid plaque contains laxatives and bulky fibrous ingredients. Thus, the ropy residue expelled from people who consume this product "certainly is a result of the figs and senna in this preparation," rather than any sort of pathologic 'plaque'. Other 'colon cleanser' products contain bentonite clay that, when ingested, would also result in production of bulky stools.
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