Molsidomine
Encyclopedia
Molsidomine is an orally active, long acting vasodilating drug
. Molsidomine is metabolized
in the liver
to the active metabolite
SIN-1
. SIN-1 is an unstable compound that releases nitric oxide
upon decay as the actual vasodilating compound.
s, a class of mesoionic
heterocyclic
aromatic chemical compound
s.
Drug
A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
. Molsidomine is metabolized
Drug metabolism
Drug metabolism is the biochemical modification of pharmaceutical substances by living organisms, usually through specialized enzymatic systems. This is a form of xenobiotic metabolism. Drug metabolism often converts lipophilic chemical compounds into more readily excreted polar products...
in the liver
Liver
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion...
to the active metabolite
Active metabolite
- Prodrugs :Sometimes drugs are formulated deliberately so they will break down inside the body to form the active drug, these are called prodrugs. The reason for this may be because the drug is more stable during manufacture and storage as the prodrug form, or because the prodrug is better...
SIN-1
Linsidomine
Linsidomine is a vasodilator.Linsidomine is a metabolite of the antianginal drug molsidomine and acts by releasing NO from the endothelial cells nonenzymatically. It also hyperpolarizes the cell membrane through influencing the sodium-potassium pump and thereby rendering it less responsive to...
. SIN-1 is an unstable compound that releases nitric oxide
Nitric oxide
Nitric oxide, also known as nitrogen monoxide, is a diatomic molecule with chemical formula NO. It is a free radical and is an important intermediate in the chemical industry...
upon decay as the actual vasodilating compound.
Chemistry
Molsidomine as well as SIN-1 are sydnone imineSydnone imine
Sydnone imine is a mesoionic heterocyclic aromatic chemical compound. Sydnone imine is the imine of sydnone where the keto functional group of sydnone has been replaced with an imine group. A sydnone imine substructure can be found in the stimulant drugs feprosidnine and mesocarb and the...
s, a class of mesoionic
Mesoionic
Mesoionic chemical compounds are dipolar five- or six- membered heterocyclic compounds in which both the negative and the positive charges are delocalized...
heterocyclic
Heterocyclic compound
A heterocyclic compound is a cyclic compound which has atoms of at least two different elements as members of its ring. The counterparts of heterocyclic compounds are homocyclic compounds, the rings of which are made of a single element....
aromatic chemical compound
Chemical compound
A chemical compound is a pure chemical substance consisting of two or more different chemical elements that can be separated into simpler substances by chemical reactions. Chemical compounds have a unique and defined chemical structure; they consist of a fixed ratio of atoms that are held together...
s.
See also
- Nitric oxideNitric oxideNitric oxide, also known as nitrogen monoxide, is a diatomic molecule with chemical formula NO. It is a free radical and is an important intermediate in the chemical industry...
- Nitric oxide releaser
- Vasodilator