Mitochondrial fission factor
Encyclopedia
Mitochondrial fission factor (Mff) is a protein
that in humans is encoded by the MFF gene
.
Mff is an outer mitochondrial membrane
protein that binds to the Drp1
GTPase that controls mitochondrial fission
. The Mff-Drp1 complex promotes mitochondrial fission. Mff also regulates peroxisome
morphology.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the MFF gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Mff is an outer mitochondrial membrane
Outer mitochondrial membrane
thumb|300px|Mitochondria structure :1) [[Inner membrane]]2) Outer membrane3) [[Crista]]4) [[Matrix |Matrix]]The outer mitochondrial membrane, which encloses the entire organelle, has a protein-to-phospholipid ratio similar to the eukaryotic plasma membrane...
protein that binds to the Drp1
DNM1L
Dynamin-1-like protein is a protein that in humans is encoded by the DNM1L gene.- Function :The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S...
GTPase that controls mitochondrial fission
Mitochondrial fission
Mitochondria can divide by fission and since they require mitochondrial DNA for their function, fission is coordinated with DNA replication. Some of the proteins that are involved in mitochondrial fission have been identified and some of them are associated with mitochondrial...
. The Mff-Drp1 complex promotes mitochondrial fission. Mff also regulates peroxisome
Peroxisome
Peroxisomes are organelles found in virtually all eukaryotic cells. They are involved in the catabolism of very long chain fatty acids, branched chain fatty acids, D-amino acids, polyamines, and biosynthesis of plasmalogens, etherphospholipids critical for the normal function of mammalian brains...
morphology.