Metallome
Encyclopedia
The term metallome has been introduced by R.J.P. Williams by analogy with proteome
as distribution of free metal
ions in every one of cellular
compartments. Subsequently, the term metallomics has been coined as the study of metallome. Szpunar (2005) defined metallomics as "comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type". Therefore, metallomics can be considered a branch of metabolomics
, even though the metals are not typically considered as metabolites.
Hiroki Haraguchi gave an alternative definition of "metallomes" as metalloprotein
s or any other metal-containing biomolecules, and "metallomics" as a study of such biomolecules.
In the study of metallomes the transcriptome, proteome and the metabolome will constitute the whole metallome. A study of the metallome is done to arrive at the metallointeractome
The metallotranscriptome (word introduced by Shanker et al 2009) by can be ideally defined as the map of the entire transcriptome in the presence of biologically or environmentally relevant concentrations of an essential or toxic metal, respectively
metallometabolome would constitute the complete pool of small metabolites in a cell at any given time
and this would give rise to the whole metallointeractome and knowledge of this would be of paramount importance in comparative metallomics dealing with toxicity and drug discovery.
(Shanker et al 2009)
Proteome
The proteome is the entire set of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the set of expressed proteins in a given type of cells or an organism at a given time under defined conditions. The term is a portmanteau of proteins and genome.The term has been...
as distribution of free metal
Metal
A metal , is an element, compound, or alloy that is a good conductor of both electricity and heat. Metals are usually malleable and shiny, that is they reflect most of incident light...
ions in every one of cellular
Cell (biology)
The cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of life that is classified as a living thing, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos....
compartments. Subsequently, the term metallomics has been coined as the study of metallome. Szpunar (2005) defined metallomics as "comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type". Therefore, metallomics can be considered a branch of metabolomics
Metabolomics
Metabolomics is the scientific study of chemical processes involving metabolites. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles...
, even though the metals are not typically considered as metabolites.
Hiroki Haraguchi gave an alternative definition of "metallomes" as metalloprotein
Metalloprotein
Metalloprotein is a generic term for a protein that contains a metal ion cofactor. Metalloproteins have many different functions in cells, such as enzymes, transport and storage proteins, and signal transduction proteins. Indeed, about one quarter to one third of all proteins require metals to...
s or any other metal-containing biomolecules, and "metallomics" as a study of such biomolecules.
In the study of metallomes the transcriptome, proteome and the metabolome will constitute the whole metallome. A study of the metallome is done to arrive at the metallointeractome
The metallotranscriptome (word introduced by Shanker et al 2009) by can be ideally defined as the map of the entire transcriptome in the presence of biologically or environmentally relevant concentrations of an essential or toxic metal, respectively
metallometabolome would constitute the complete pool of small metabolites in a cell at any given time
and this would give rise to the whole metallointeractome and knowledge of this would be of paramount importance in comparative metallomics dealing with toxicity and drug discovery.
(Shanker et al 2009)