Marburg multiple sclerosis
Encyclopedia
Marburg multiple sclerosis, also known as fulminant multiple sclerosis
, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. Other diseases in this group are Neuromyelitis optica
(NMO), Balo concentric sclerosis
, and Schilder's disease
. The term malignant is sometime used to describe the grave course of this MS variant. However, malignant multiple sclerosis
is a broader term used to describe MS patients who reach significant level of disability in less than 5 years from their first symptoms
It took its name from Otto Marburg
. It can be diagnosed in vivo with an MRI scan.
If Marburg Disease occurs in the form of a single large lesion, it can be radialogically indistinguishable from a brain tumor or abscess. In such cases, craniotomy and biopsy is needed to exclude other pathologies.
It is usually lethal, but it has been found to be responsive to Mitoxantrone
and Alemtuzumab
, and it has also been responsive to autologous stem cell transplantation
. Recently it has been shown that it presents a heterogeneous response to medication, as does standard MS.
Multiple sclerosis
Multiple sclerosis is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms...
, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. Other diseases in this group are Neuromyelitis optica
Devic's disease
Neuromyelitis optica , also known as Devic's disease or Devic's syndrome, is an autoimmune, inflammatory disorder in which a person's own immune system attacks the optic nerves and spinal cord. This produces an inflammation of the optic nerve and the spinal cord...
(NMO), Balo concentric sclerosis
Balo concentric sclerosis
Balo concentric sclerosis is one of the borderline forms of multiple sclerosis.Balo concentric sclerosis is a demyelinating disease similar to standard multiple sclerosis, but with the particularity that the demyelinated tissues form concentric layers...
, and Schilder's disease
Schilder's disease
Schilder's disease may refer to two different diseases described by Paul Schilder:* Adrenoleukodystrophy* Diffuse myelinoclastic sclerosis...
. The term malignant is sometime used to describe the grave course of this MS variant. However, malignant multiple sclerosis
Malignant multiple sclerosis
The term malignant multiple sclerosis is often used to describe MS patients who reach significant level of disability in less than 5 years from their first symptoms...
is a broader term used to describe MS patients who reach significant level of disability in less than 5 years from their first symptoms
It took its name from Otto Marburg
Otto Marburg
Dr. Otto Marburg was a doctor who was born in Austria Hungary.-Career:He was head of the University of Vienna's Neurological Institute for 19 years. He later went to the U.S...
. It can be diagnosed in vivo with an MRI scan.
If Marburg Disease occurs in the form of a single large lesion, it can be radialogically indistinguishable from a brain tumor or abscess. In such cases, craniotomy and biopsy is needed to exclude other pathologies.
It is usually lethal, but it has been found to be responsive to Mitoxantrone
Mitoxantrone
Mitoxantrone is an anthracenedione antineoplastic agent.-Uses:It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma...
and Alemtuzumab
Alemtuzumab
Alemtuzumab is a monoclonal antibody used in the treatment of chronic lymphocytic leukemia , cutaneous T-cell lymphoma and T-cell lymphoma...
, and it has also been responsive to autologous stem cell transplantation
Autologous stem cell transplantation
Autologous stem cell transplantation is a medical procedure in which blood-forming stem cells are removed, stored, and later given back to the same person.- External link :...
. Recently it has been shown that it presents a heterogeneous response to medication, as does standard MS.
External links
- Marburg's Variant (Mult-sclerosis Encyclopedia)