A manuscript or handwrite is written information

Information

Information in its most restricted technical sense is a message or collection of messages that consists of an ordered sequence of symbols, or it is the meaning that can be interpreted from such a message or collection of messages. Information can be recorded or transmitted. It can be recorded as...

 that has been manually created by someone or some people, such as a hand-written letter, as opposed to being printed or reproduced some other way. The term may also be used for information that is hand-recorded in other ways than writing, for example inscriptions that are chiselled upon a hard material or scratched (the original meaning of graffiti

Graffiti

Graffiti is the name for images or lettering scratched, scrawled, painted or marked in any manner on property....

) as with a knife point in plaster or with a stylus

Stylus

A stylus is a writing utensil, or a small tool for some other form of marking or shaping, for example in pottery. The word is also used for a computer accessory . It usually refers to a narrow elongated staff, similar to a modern ballpoint pen. Many styli are heavily curved to be held more easily...

 on a waxed tablet (the way Romans made notes), or are in cuneiform writing

Cuneiform script

Cuneiform script )) is one of the earliest known forms of written expression. Emerging in Sumer around the 30th century BC, with predecessors reaching into the late 4th millennium , cuneiform writing began as a system of pictographs...

, impressed with a pointed stylus in a flat tablet of unbaked clay.