Low density lipoprotein receptor-related protein 4
Encyclopedia
Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a protein
that in humans is encoded by the LRP4 gene
. LRP-4 is a member of the Lipoprotein receptor-related protein
family and may be a regulator of Wnt signaling
.
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the LRP4 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. LRP-4 is a member of the Lipoprotein receptor-related protein
Lipoprotein receptor-related protein
Lipoprotein receptor-related proteins, low density lipoprotein receptor-related proteins or prolow-density lipoprotein receptor-related protein , abbreviated LRP, are a group of proteins.They include:*LRP1*LRP1B...
family and may be a regulator of Wnt signaling
Wnt signaling pathway
The Wnt signaling pathway is a network of proteins best known for their roles in embryogenesis and cancer, but also involved in normal physiological processes in adult animals.-Discovery:...
.
Clinical significance
Mutations in this gene are associated with Cenani Lenz syndactylismCenani Lenz syndactylism
Cenani Lenz syndactylism, also known as Cenani Lenz syndrome or Cenani syndactylism, is an autosomal recessive congenital malformation syndrome involving both upper and lower extremities.-Characteristics:...
.