Levonantradol
Encyclopedia
Levonantradol is a synthetic
cannabinoid analog
of dronabinol (Marinol) developed by Pfizer
in the 1980s. It is around 30x more potent than THC
, and exhibits antiemetic
and analgesic
effects via activation of CB1 and CB2 cannabinoid receptor
s. Levonantradol is not currently used in medicine as dronabinol or nabilone
are felt to be more useful for most conditions, however it is widely used in research into the potential therapeutic applications of cannabinoids.
Chemical synthesis
In chemistry, chemical synthesis is purposeful execution of chemical reactions to get a product, or several products. This happens by physical and chemical manipulations usually involving one or more reactions...
cannabinoid analog
Analog (chemistry)
In chemistry, a structural analog , also known as chemical analog or simply analog, is a compound having a structure similar to that of another one, but differing from it in respect of a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced...
of dronabinol (Marinol) developed by Pfizer
Pfizer
Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...
in the 1980s. It is around 30x more potent than THC
THC
THC commonly refers to tetrahydrocannabinol, the main active chemical compound in Cannabis.THC may also refer to:* Tan Holdings Corporation...
, and exhibits antiemetic
Antiemetic
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer....
and analgesic
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
effects via activation of CB1 and CB2 cannabinoid receptor
Cannabinoid receptor
The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains...
s. Levonantradol is not currently used in medicine as dronabinol or nabilone
Nabilone
Nabilone is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It is a synthetic cannabinoid, which mimics the main ingredient of cannabis...
are felt to be more useful for most conditions, however it is widely used in research into the potential therapeutic applications of cannabinoids.