Leucocyte common antigen
Encyclopedia
Leucocyte common antigen family is a group of high molecular weight glycoprotein
s uniquely expressed on the surface of all leukocytes and their hemopoietic progenitor cells.
Members of this family differ by their protein
sequence and carbohydrate
structure. Each leukocyte population expresses LCA in a particular pattern. Thymocytes express the lowest molecular weight form, B lymphocytes express the highest molecular weight form. T lymphocytes express a variety of intermediate forms. All in all, LCA are a major constituent of lymphocyte
membrane
s, occupying up to 10% of their surface.
Glycoprotein
Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...
s uniquely expressed on the surface of all leukocytes and their hemopoietic progenitor cells.
Members of this family differ by their protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
sequence and carbohydrate
Carbohydrate
A carbohydrate is an organic compound with the empirical formula ; that is, consists only of carbon, hydrogen, and oxygen, with a hydrogen:oxygen atom ratio of 2:1 . However, there are exceptions to this. One common example would be deoxyribose, a component of DNA, which has the empirical...
structure. Each leukocyte population expresses LCA in a particular pattern. Thymocytes express the lowest molecular weight form, B lymphocytes express the highest molecular weight form. T lymphocytes express a variety of intermediate forms. All in all, LCA are a major constituent of lymphocyte
Lymphocyte
A lymphocyte is a type of white blood cell in the vertebrate immune system.Under the microscope, lymphocytes can be divided into large lymphocytes and small lymphocytes. Large granular lymphocytes include natural killer cells...
membrane
Biological membrane
A biological membrane or biomembrane is an enclosing or separatingmembrane that acts as a selective barrier, within or around a cell. It consists of a lipid bilayer with embedded proteins that may constitute close to 50% of membrane content...
s, occupying up to 10% of their surface.