Lattice corneal dystrophy type I (LCD1; Biber-Haab-Dimmer dystrophy) is a rare form of human corneal dystrophy

Corneal dystrophy (human)

Human corneal dystrophy is a group of disorders, characterised by a noninflammatory, inherited, bilateral opacity of the transparent front part of the human eye called the cornea...

. It is caused by mutations in TGFBI

TGFBI

Transforming growth factor, beta-induced, 68kDa, also known as TGFBI , is a protein which in humans is encoded by the TGFBI gene.- Function :...

 gene encoding keratoepithelin. It has no systemic manifestations, unlike the other type of the dystrophy, LCDII. Filamentous opacities appear in the cornea

Cornea

The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber. Together with the lens, the cornea refracts light, with the cornea accounting for approximately two-thirds of the eye's total optical power. In humans, the refractive power of the cornea is...

 with intertwining delicate branch

Branch

A branch or tree branch is a woody structural member connected to but not part of the central trunk of a tree...

ing processes. The disease

Disease

A disease is an abnormal condition affecting the body of an organism. It is often construed to be a medical condition associated with specific symptoms and signs. It may be caused by external factors, such as infectious disease, or it may be caused by internal dysfunctions, such as autoimmune...

 is bilateral, usually noted before the end of the first decade of life

Life

Life is a characteristic that distinguishes objects that have signaling and self-sustaining processes from those that do not, either because such functions have ceased , or else because they lack such functions and are classified as inanimate...

.

LCDI was first described by Swiss ophthalmologist Hugo Biber in 1890.