Lamin B receptor
Encyclopedia
Lamin-B receptor is a protein
that in humans is encoded by the LBR gene
.
.
with CBX3
and CBX5
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the LBR gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Clinical significance
There is evidence tying it to Greenberg dysplasia and Pelger-Huet anomalyPelger-Huet anomaly
Pelger-Huet anomaly is a blood laminopathy associated with the lamin B receptor.It is characterized by a white blood cell type known as a neutrophil whose nucleus is hyposegmented.It is a genetic disorder with an autosomal dominant inheritance pattern...
.
Interactions
Lamin B receptor has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with CBX3
CBX3
Chromobox protein homolog 3 is a protein that in humans is encoded by the CBX3 gene.-Interactions:CBX3 has been shown to interact with PIM1, Ki-67, Lamin B receptor, CBX5 and CBX1....
and CBX5
CBX5 (gene)
Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene.-Interactions:CBX5 has been shown to interact with HDAC9, Ku70, MIS12, Lamin B receptor, MBD1, TAF4, Histone deacetylase 5, TRIM28, HDAC4, CBX3, SMARCA4, DNMT3B, CHAF1A, CBX1 and SUV39H1....
.