Keratin 6B
Encyclopedia
Keratin 6B is a type II cytokeratin
, one of a number of isoforms of keratin 6. It is found with keratin 16
and/or keratin 17
in the hair follicles, the filiform papillae of the tongue
and the epithelial lining of oral mucosa and esophagus
. This keratin 6 isoform is thought be less abundant than the closely related keratin 6A
protein. Mutations in the gene encoding this protein have been associated with pachyonychia congenita
, an inherited disorder of the epithelial tissues in which this keratin is expressed, particularly leading to structural abnormalities of the nails
, the epidermis of the palms and soles, and oral epithelia. Keratin 6B has been associated with the PC2 variant of pachyonychia congenita
where affected individuals may develop more skin cysts than the PC1 type.
Keratin
Keratin refers to a family of fibrous structural proteins. Keratin is the key of structural material making up the outer layer of human skin. It is also the key structural component of hair and nails...
, one of a number of isoforms of keratin 6. It is found with keratin 16
Keratin 16
Keratin 16 is a protein that in humans is encoded by the KRT16 gene.Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles...
and/or keratin 17
Keratin 17
Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages...
in the hair follicles, the filiform papillae of the tongue
Tongue
The tongue is a muscular hydrostat on the floors of the mouths of most vertebrates which manipulates food for mastication. It is the primary organ of taste , as much of the upper surface of the tongue is covered in papillae and taste buds. It is sensitive and kept moist by saliva, and is richly...
and the epithelial lining of oral mucosa and esophagus
Esophagus
The esophagus is an organ in vertebrates which consists of a muscular tube through which food passes from the pharynx to the stomach. During swallowing, food passes from the mouth through the pharynx into the esophagus and travels via peristalsis to the stomach...
. This keratin 6 isoform is thought be less abundant than the closely related keratin 6A
Keratin 6A
Keratin 6A is a protein that in humans is encoded by the KRT6A gene.- Keratins :Keratins are the intermediate filament proteins that form a dense meshwork of filaments throughout the cytoplasm of epithelial cells. Keratins form heteropolymers consisting of a type I and a type II keratin...
protein. Mutations in the gene encoding this protein have been associated with pachyonychia congenita
Pachyonychia congenita
Pachyonychia congenita, also called Jadassohn-Lewandowski Syndrome or simply pachyonychia, is an autosomal dominant skin disorder.-Symptoms:Common symptoms include:*Excess keratin in nail beds and thickening of the nails...
, an inherited disorder of the epithelial tissues in which this keratin is expressed, particularly leading to structural abnormalities of the nails
Nail (anatomy)
A nail is a horn-like envelope covering the dorsal aspect of the terminal phalanges of fingers and toes in humans, most non-human primates, and a few other mammals. Nails are similar to claws, which are found on numerous other animals....
, the epidermis of the palms and soles, and oral epithelia. Keratin 6B has been associated with the PC2 variant of pachyonychia congenita
Pachyonychia congenita
Pachyonychia congenita, also called Jadassohn-Lewandowski Syndrome or simply pachyonychia, is an autosomal dominant skin disorder.-Symptoms:Common symptoms include:*Excess keratin in nail beds and thickening of the nails...
where affected individuals may develop more skin cysts than the PC1 type.