Keratin 17
Encyclopedia
Keratin, type I cytoskeletal 17 is a protein
that in humans is encoded by the KRT17 gene
.
Keratin 17 is a type I cytokeratin
. It is found in nail bed
s, hair follicle
s, sebaceous gland
s, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex
.
with CCDC85B
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the KRT17 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Keratin 17 is a type I cytokeratin
Type I cytokeratin
Type I keratins constitutes the Type I intermediate filaments of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells...
. It is found in nail bed
Nail bed
Nail bed can refer to:* Bed of nails, a device sometimes used in meditation and physics demonstrations* Bed of nails tester, a device used to test printed circuit boards* Fingernail region also known as the "quick"...
s, hair follicle
Hair follicle
A hair follicle is a skin organ that produces hair. Hair production occurs in phases, including a growth phase , and cessation phase , and a rest phase . Stem cells are principally responsible for the production of hair....
s, sebaceous gland
Sebaceous gland
The sebaceous glands are microscopic glands in the skin that secrete an oily/waxy matter, called sebum, to lubricate and waterproof the skin and hair of mammals...
s, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex
Steatocystoma multiplex
Steatocystoma multiplex is a benign, autosomal dominant congenital condition resulting in multiple cysts on a person's body....
.
Interactions
Keratin 17 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with CCDC85B
CCDC85B
Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene.-Interactions:CCDC85B has been shown to interact with KIAA1267, Keratin 17, Protein kinase N1 and C19orf25.-Further reading:...
.