Kin of IRRE-like protein 3 (KIRREL3) also known as nin of irregular chiasm-like protein 3 or nephrin-like protein 2 (NEPH2) is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the KIRREL3 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

NEPH2 is a member of the nephrin-like protein family of transmembrane protein

Transmembrane protein

A transmembrane protein is a protein that goes from one side of a membrane through to the other side of the membrane. Many TPs function as gateways or "loading docks" to deny or permit the transport of specific substances across the biological membrane, to get into the cell, or out of the cell as...

s, which includes NEPH1 (KIRREL

KIRREL

Kin of IRRE-like protein 1 is a protein that in humans is encoded by the KIRREL gene.-Interactions:KIRREL has been shown to interact with Nephrin and Tight junction protein 1.-Further reading:...

) and NEPH3 (KIRREL2

KIRREL2

Kin of IRRE-like protein 2 is a protein that in humans is encoded by the KIRREL2 gene.-Further reading:...

). The nephrin-like proteins can interact with nephrin

Nephrin

Nephrin is a protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells...

 and CASK

CASK

Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2 , calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2.-Genomics:This gene is located on the short arm of...

.

Function

NEPH2 has been implicated in synapse

Synapse

In the nervous system, a synapse is a structure that permits a neuron to pass an electrical or chemical signal to another cell...

 formation. Disruption of KIRREL3 gene function had been associated with abnormal brain

Brain

The brain is the center of the nervous system in all vertebrate and most invertebrate animals—only a few primitive invertebrates such as sponges, jellyfish, sea squirts and starfishes do not have one. It is located in the head, usually close to primary sensory apparatus such as vision, hearing,...

 function.

NEPH1

KIRREL

Kin of IRRE-like protein 1 is a protein that in humans is encoded by the KIRREL gene.-Interactions:KIRREL has been shown to interact with Nephrin and Tight junction protein 1.-Further reading:...

 and NEPH2 are involved in the blood filtration

Ultrafiltration (renal)

In biological terms, ultrafiltration occurs at the barrier between the blood and the filtrate in the renal corpuscle or Bowman's capsule in the kidneys. The Bowman's capsule contains a dense capillary network called the glomerulus. Blood flows into these capillaries through a wide afferent...

 function of the kidney

Kidney

The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...

 and are located in the slit diaphragm.