Journal of Molecular Biology
Encyclopedia
The Journal of Molecular Biology is a peer-reviewed
scientific journal
published weekly by Elsevier
. It covers original scientific research concerning studies of organisms or their components at the molecular level.
Peer review
Peer review is a process of self-regulation by a profession or a process of evaluation involving qualified individuals within the relevant field. Peer review methods are employed to maintain standards, improve performance and provide credibility...
scientific journal
Scientific journal
In academic publishing, a scientific journal is a periodical publication intended to further the progress of science, usually by reporting new research. There are thousands of scientific journals in publication, and many more have been published at various points in the past...
published weekly by Elsevier
Elsevier
Elsevier is a publishing company which publishes medical and scientific literature. It is a part of the Reed Elsevier group. Based in Amsterdam, the company has operations in the United Kingdom, USA and elsewhere....
. It covers original scientific research concerning studies of organisms or their components at the molecular level.
Notable articles
Some of the most highly cited articles that have appeared in the Journal of Molecular Biology since its inception in April 1959 include:- "On the nature of allosteric transitions: a plausible model," in 1965, in which Jacques MonodJacques MonodJacques Lucien Monod was a French biologist who was awarded a Nobel Prize in Physiology or Medicine in 1965, sharing it with François Jacob and Andre Lwoff "for their discoveries concerning genetic control of enzyme and virus synthesis"...
, Jeffries Wyman, and Jean-Pierre ChangeuxJean-Pierre ChangeuxJean-Pierre Changeux is a French neuroscientist known for his research in several fields of biology, from the structure and function of proteins , to the early development of the nervous system up to cognitive functions...
presented the MWC modelMWC modelIn biochemistry, the MWC model describes allosteric transitions of proteins made up of identical subunits. It was proposed by Jean-Pierre Changeux based on his PhD experiments, and described by Jacques Monod, Jeffries Wyman, and Jean-Pierre Changeux...
, that explained the cooperativity exhibited by allosteric proteins, such as hemoglobinHemoglobinHemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates, with the exception of the fish family Channichthyidae, as well as the tissues of some invertebrates...
. - "Detection of Specific Sequences Among DNA Fragments Separated by Gel-Electrophoresis," in 1975, in which Edwin SouthernEdwin SouthernSir Edwin Mellor Southern, FRS is an English 2005 Lasker Award-winning molecular biologist. His award was for the invention of the Southern blot, now a common laboratory procedure, when he was working at the University of Edinburgh....
presented the first description of nucleic acid blottingBlot (biology)In molecular biology and genetics, a blot is a method of transferring proteins, DNA or RNA, onto a carrier . In many instances, this is done after a gel electrophoresis, transferring the molecules from the gel onto the blotting membrane, and other times adding the samples directly onto the membrane...
, a technique that revolutionized the field of molecular biology. - "Identification of Common Molecular Subsequences," in 1981, in which the Smith–Waterman algorithm for determining the degree of homology of DNA, RNA, or protein sequences was first described.
- "Basic Local Alignment Search Tool," in 1990, in which the nucleic acid and protein homology search algorithm known as BLASTBLASTIn bioinformatics, Basic Local Alignment Search Tool, or BLAST, is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of different proteins or the nucleotides of DNA sequences...
was originally described.