Iodotyrosine deiodinase
Encyclopedia
Iodotyrosine deiodinase also known as iodotyrosine dehalogenase 1 is an enzyme
that in humans is encoded by the IYD gene
.
- and diiodotyrosine
, the halogenated byproducts of thyroid hormone
production.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the IYD gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
Iodotyrosine deiodinase facilitates iodide salvage in thyroid by catalyzing deiodination of monoMonoiodotyrosine
Monoiodotyrosine is a precursor of thyroid hormone and results from iodization of tyrosine at the meta- position of the phenol ring.Two units can combine to form 3,3'-diiodothyronine. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid...
- and diiodotyrosine
Diiodotyrosine
Diiodotyrosine is a precursor of thyroid hormone and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring....
, the halogenated byproducts of thyroid hormone
Thyroid hormone
The thyroid hormones, thyroxine and triiodothyronine , are tyrosine-based hormones produced by the thyroid gland primarily responsible for regulation of metabolism. An important component in the synthesis of thyroid hormones is iodine. The major form of thyroid hormone in the blood is thyroxine ,...
production.