Diiodotyrosine
Encyclopedia
Diiodotyrosine is a precursor of thyroid hormone
and results from iodization of monoiodotyrosine
at the other meta-
position on the phenol
ring.
DIT is a modulator of thyroid peroxidase
. When combined with monoiodotyrosine
in the colloid of the thyroid follicle, triiodothyronine
is formed. Two molecules of DIT combine to make thyroxine
.
Thyroid hormone
The thyroid hormones, thyroxine and triiodothyronine , are tyrosine-based hormones produced by the thyroid gland primarily responsible for regulation of metabolism. An important component in the synthesis of thyroid hormones is iodine. The major form of thyroid hormone in the blood is thyroxine ,...
and results from iodization of monoiodotyrosine
Monoiodotyrosine
Monoiodotyrosine is a precursor of thyroid hormone and results from iodization of tyrosine at the meta- position of the phenol ring.Two units can combine to form 3,3'-diiodothyronine. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid...
at the other meta-
Meta- (chemistry)
In chemistry, meta is a prefix, used for systematic names in IUPAC nomenclature. It has several meanings. *In organic chemistry, meta indicates the positions of substituents in aromatic cyclic compounds...
position on the phenol
Phenol
Phenol, also known as carbolic acid, phenic acid, is an organic compound with the chemical formula C6H5OH. It is a white crystalline solid. The molecule consists of a phenyl , bonded to a hydroxyl group. It is produced on a large scale as a precursor to many materials and useful compounds...
ring.
DIT is a modulator of thyroid peroxidase
Thyroid peroxidase
Thyroid peroxidase or thyroperoxidase is an enzyme expressed mainly in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of thyroxine or triiodothyronine , thyroid hormones. In humans, thyroperoxidase is encoded by the TPO...
. When combined with monoiodotyrosine
Monoiodotyrosine
Monoiodotyrosine is a precursor of thyroid hormone and results from iodization of tyrosine at the meta- position of the phenol ring.Two units can combine to form 3,3'-diiodothyronine. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid...
in the colloid of the thyroid follicle, triiodothyronine
Triiodothyronine
Triiodothyronine, C15H12I3NO4, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate....
is formed. Two molecules of DIT combine to make thyroxine
Thyroxine
Thyroxine, or 3,5,3',5'-tetraiodothyronine , a form of thyroid hormones, is the major hormone secreted by the follicular cells of the thyroid gland.-Synthesis and regulation:...
.