Immunoglobulin domain
Encyclopedia
The immunoglobulin domain is a type of protein domain
that consists of a 2-layer sandwich of between 7 and 9 antiparallel β-strands
arranged in two β-sheets
with a Greek key topology.
The backbone switches repeatedly between the two β-sheets. Typically, the pattern is (N-terminal β-hairpin in sheet 1)-(β-hairpin in sheet 2)-(β-strand in sheet 1)-(C-terminal β-hairpin in sheet 2). The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other.
Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies
, the giant muscle kinase titin
and receptor tyrosine kinase
s. Immunoglobulin-like domains may be involved in protein–protein and protein–ligand
interactions.
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
that consists of a 2-layer sandwich of between 7 and 9 antiparallel β-strands
Beta sheet
The β sheet is the second form of regular secondary structure in proteins, only somewhat less common than the alpha helix. Beta sheets consist of beta strands connected laterally by at least two or three backbone hydrogen bonds, forming a generally twisted, pleated sheet...
arranged in two β-sheets
Beta sheet
The β sheet is the second form of regular secondary structure in proteins, only somewhat less common than the alpha helix. Beta sheets consist of beta strands connected laterally by at least two or three backbone hydrogen bonds, forming a generally twisted, pleated sheet...
with a Greek key topology.
The backbone switches repeatedly between the two β-sheets. Typically, the pattern is (N-terminal β-hairpin in sheet 1)-(β-hairpin in sheet 2)-(β-strand in sheet 1)-(C-terminal β-hairpin in sheet 2). The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other.
Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies
Antibody
An antibody, also known as an immunoglobulin, is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a unique part of the foreign target, termed an antigen...
, the giant muscle kinase titin
Titin
Titin , also known as connectin, is a protein that in humans is encoded by the TTN gene. Titin is a giant protein that functions as a molecular spring which is responsible for the passive elasticity of muscle. It is composed of 244 individually folded protein domains connected by unstructured...
and receptor tyrosine kinase
Receptor tyrosine kinase
Receptor tyrosine kinases s are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins....
s. Immunoglobulin-like domains may be involved in protein–protein and protein–ligand
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In a narrower sense, it is a signal triggering molecule, binding to a site on a target protein.The binding occurs by intermolecular forces, such as ionic bonds, hydrogen...
interactions.
Examples
Human genes encoding proteins containing the immunoglobulin domain include:- A1BG
- ACAM
- ADAMTSL1ADAMTSL1ADAMTS-like protein 1 is a protein that in humans is encoded by the ADAMTSL1 gene.-Further reading:...
- ADAMTSL3
- AGER
- ALCAMALCAMCD166 antigen is a protein that in humans is encoded by the ALCAM gene.. It is also called CD166 .-External links:...
- AMIGO1
- AMIGO2
- AXLAXL receptor tyrosine kinaseTyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene.-Interactions:AXL receptor tyrosine kinase has been shown to interact with TENC1.-Further reading:...
- BCAMBCAMBasal cell adhesion molecule is a protein that in humans is encoded by the BCAM gene. BCAM has also recently been designated CD239 .-Interactions:BCAM has been shown to interact with Laminin, alpha 5....
- BOCBOC (gene)Brother of CDO is a protein that in humans is encoded by the BOC gene.-Interactions:BOC has been shown to interact with CDON.-Further reading:...
- BSGBasiginBasigin also known as extracellular matrix metalloproteinase inducer or cluster of differentiation 147 is a protein that in humans is encoded by the BSG gene. This protein is a determinant for the Ok blood group system...
- BTLABTLAB- and T-lymphocyte attenuator is a protein that in humans is encoded by the BTLA gene. BTLA has also been designated as CD272 .- Function :...
- C10orf72
- C20orf102
- CADM1Cell adhesion molecule 1Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.-Interactions:Cell adhesion molecule 1 has been shown to interact with EPB41L3.-Further reading:...
- CADM3CADM3Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.-Further reading:...
- CD200CD200CD200 is a human protein encoded by the gene....
- CD22CD22CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells...
- CD276CD276CD276 is a human protein encoded by the gene....
- CD33CD33CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.It binds sialic acids, therefore is a member of the SIGLEC family of lectins....
- CD4CD4CD4 is a glycoprotein expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 before being named CD4 in 1984...
- CDONCDONCell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.-Interactions:CDON has been shown to interact with CDH1 and BOC.-Further reading:...
- CEACAM1CEACAM1Carcinoembryonic antigen-related cell adhesion molecule 1 also known as CD66a , is a human gene.-Interactions:...
- CEACAM16CEACAM16CEACAM16 is a gene which encodes carcinoembryonic antigen....
- CEACAM20CEACAM20CEACAM20 is a gene which encodes carcinoembryonic antigen....
- CEACAM21CEACAM21CEACAM21 is a gene which encodes carcinoembryonic antigen....
- CEACAM5CEACAM5Carcinoembryonic antigen-related cell adhesion molecule 5 also known as CD66e , is a human gene.-Further reading:...
- CEACAM6CEACAM6Carcinoembryonic antigen-related cell adhesion molecule 6 also known as CD66c , is a human gene.-External links:...
- CEACAM8CEACAM8Carcinoembryonic antigen-related cell adhesion molecule 8 also known as CD66b , is a human gene.-Further reading:...
- CHL1CHL1Neural cell adhesion molecule L1-like protein also known as close homolog of L1 is a protein that in humans is encoded by the CHL1 gene.CHL1 is a cell adhesion molecule closely related to the L1...
- CILPCILPCartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene.-Further reading:...
- CNTFRCiliary neurotrophic factor receptorThe ciliary neurotrophic factor receptor also known as CNTFR binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the survival of neurons. This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the...
- CNTN1CNTN1Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene.- Function :The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol -anchored neuronal membrane protein that functions as a cell adhesion molecule...
- CNTN2CNTN2Contactin-2 is a protein that in humans is encoded by the CNTN2 gene.-Interactions:CNTN2 has been shown to interact with CNTNAP2 and NFYB.-Further reading:...
- CNTN3CNTN3Contactin-3 is a protein that in humans is encoded by the CNTN3 gene.-Further reading:...
- CNTN4CNTN4Contactin-4 is a protein that in humans is encoded by the CNTN4 gene.-Genomics:The gene is located on the short arm of chromosome 3...
- CNTN5
- CNTN6
- CSF1RColony stimulating factor 1 receptorColony stimulating factor 1 receptor , also known as macrophage colony-stimulating factor receptor , and CD115 , is a cell-surface protein encoded, in humans, by the CSF1R gene...
- DSCAMDSCAMDSCAM and Dscam are both abbreviations for Down Syndrome Cell Adhesion Molecule. The case difference is significant: DSCAM refers to the human protein, and Dscam refers to its analog in Drosophila....
- DSCAML1
- EMB
- F11RF11 receptorJunctional adhesion molecule A is a protein that in humans is encoded by the F11R gene. KDR has also been designated as CD321 .-Interactions:...
- FAIM3
- FCARFCARFc fragment of IgA receptor also known as CD89 , is a human gene.-Further reading:-External links:...
- FCER1AFCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene.- Function :...
- FCGR1AFCGR1AHigh affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.-Further reading:...
- FCGR2AFCGR2ALow affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.-Interactions:FCGR2A has been shown to interact with PIK3R1 and Syk.-Further reading:- External links :...
- FCGR2BFCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b is a protein that in humans is encoded by the FCGR2B gene. Mutation in the gene in humans leads to a lupus phenotype. The cytoplasmic part of this receptor contains an immunoreceptor tyrosine-based inhibitory motif.-Further reading:...
- FCGR2C
- FCGR3AFCGR3ALow affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene. It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.-Further reading:...
- FCGR3BFCGR3BFCGR3B , also known as CD16b , is a human gene.-Further reading:...
- FCRH1
- FCRH3
- FCRH4
- FCRL1FCRL1Fc receptor-like protein 1 is a protein that in humans is encoded by the FCRL1 gene.-Further reading:...
- FCRL2FCRL2Fc receptor-like protein 2 is a protein that in humans is encoded by the FCRL2 gene.-Further reading:...
- FCRL3FCRL3Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.-Further reading:...
- FCRL4FCRL4Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene.-Further reading:...
- FCRL5FCRL5Fc receptor-like protein 5 is a protein that in humans is encoded by the FCRL5 gene. FCRL5 has also been designated as CD307 ....
- FCRL6
- FCRLAFCRLAFc receptor-like A is a protein that in humans is encoded by the FCRLA gene.-Further reading:...
- FGFR1
- FGFR2
- FGFR3FGFR3Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 .-Structure and function:-Disease linkage:...
- FGFR4
- FGFRL1FGFRL1Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene.-Further reading:...
- FLT1FLT1Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.-Interactions:FLT1 has been shown to interact with PLCG1 and Vascular endothelial growth factor B.-Further reading:...
- FLT3CD135Cluster of differentiation antigen 135 also known as Fms-like tyrosine kinase 3 or receptor-type tyrosine-protein kinase FLT3 is a protein that in humans is encoded by the FLT3 gene...
- FLT4FLT4Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic...
- FSTL4
- FSTL5
- GP6GPVIGlycoprotein VI also known as GPVI is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GPVI gene.- Function :...
- GPA33GPA33Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.-Further reading:...
- GPR116GPR116Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene.-Further reading:...
- GPR125GPR125Probable G-protein coupled receptor 125 is a protein that in humans is encoded by the GPR125 gene.-Further reading:...
- HEPACAMHEPACAMGene hapaCAM was identified, isolated, characterized and first reported by Dr Shali SHEN et.al. in 2005[1]. The gene encodes a protein hepaCAM of 416 aa, which is a new immunoglobulin-like cell adhesion molecule and a putative tumor suppressor...
- HLA-DMAHLA-DMAHLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene.-Further reading:...
- HLA-DMBHLA-DMBHLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the HLA-DMB gene.-Further reading:...
- HLA-DQB
- HLA-DQB1HLA-DQB1Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic locus that contains this gene...
- HMCN1HMCN1Hemicentin-1 is a protein that in humans is encoded by the HMCN1 gene.-Further reading:...
- HNTHNTNeurotrimin is a protein that in humans is encoded by the NTM gene.-Further reading:...
- HSPG2PerlecanPerlecan also known as basement membrane-specific heparan sulfate proteoglycan core protein or heparan sulfate proteoglycan 2 , is a protein that in humans is encoded by the HSPG2 gene....
- HYST2477
- ICAM3ICAM3Intercellular adhesion molecule 3 also known as CD50 , is a human gene.-Interactions:ICAM3 has been shown to interact with EZR and Moesin.-Further reading:...
- ICAM5ICAM5Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.-Further reading:...
- IGHA1
- IGHDIGHDIg delta chain C region is a protein that in humans is encoded by the IGHD gene.-Further reading:...
- IGHEIGHEIg epsilon chain C region is a protein that in humans is encoded by the IGHE gene.-Further reading:...
- IGSF10
- IGSF11
- IGSF2IGSF2Immunoglobulin superfamily, member 2 also known as CD101 , is a human gene....
- IGSF21
- IGSF3
- IGSF9
- IL11RAInterleukin 11 receptor alpha subunitInterleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.-Further reading:...
- IL1R1Interleukin 1 receptor, type IInterleukin 1 receptor, type I also known as CD121a , is an interleukin receptor. IL1R1 also denotes its human gene.-Interactions:...
- IL1R2Interleukin 1 receptor, type IIInterleukin 1 receptor, type II also known as CD121b is an interleukin receptor. IL1R2 also denotes its human gene.-External links:...
- IL1RAPL1IL1RAPL1X-linked interleukin-1 receptor accessory protein-like 1 is a protein that in humans is encoded by the IL1RAPL1 gene.-Further reading:...
- IL1RAPL2IL1RAPL2X-linked interleukin-1 receptor accessory protein-like 2 is a protein that in humans is encoded by the IL1RAPL2 gene.-Further reading:...
- IL1RL1IL1RL1Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the IL1RL1 gene.- Function :The protein encoded by this gene is a member of the interleukin-1 receptor family...
- IL1RL2IL1RL2Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.-Further reading:...
- IL6RInterleukin-6 receptorInterleukin 6 receptor also known as CD126 is a type I cytokine receptor....
- JAM2JAM2Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322 ....
- JAM3JAM3Junctional adhesion molecule C is a protein that in humans is encoded by the JAM3 gene.-Further reading:...
- KIR-123FM
- KIR2DL1KIR2DL1Killer cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the KIR2DL1 gene.-Further reading:...
- KIR2DL2
- KIR2DL3
- KIR2DL4KIR2DL4Killer cell immunoglobulin-like receptor 2DL4 is a protein that in humans is encoded by the KIR2DL4 gene.-Further reading:...
- KIR2DL5A
- KIR2DL5B
- KIR2DLX
- KIR2DS1
- KIR2DS2
- KIR2DS3
- KIR2DS4KIR2DS4Killer cell immunoglobulin-like receptor 2DS4 is a protein that in humans is encoded by the KIR2DS4 gene.-Further reading:...
- KIR2DS5
- KIR3DL1KIR3DL1Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene.-Further reading:...
- KIR3DL2KIR3DL2Killer cell immunoglobulin-like receptor 3DL2 is a protein that in humans is encoded by the KIR3DL2 gene.-Further reading:...
- KIR3DL3KIR3DL3Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene....
- KIR3DS1
- KITCD117Mast/stem cell growth factor receptor also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117 is a protein that in humans is encoded by the KIT gene...
- L1CAM
- LAG3LAG3Lymphocyte-activation gene 3, also known as LAG3, is a protein which in humans is encoded by the LAG3 gene. LAG3 has also recently been designated CD223 ....
- LILRA1
- LILRA2LILRA2Leukocyte immunoglobulin-like receptor subfamily A member 2 is a protein that in humans is encoded by the LILRA2 gene....
- LILRA3LILRA3Leukocyte immunoglobulin-like receptor subfamily A member 3 also known as CD85 antigen-like family member E , immunoglobulin-like transcript 6 , and leukocyte immunoglobulin-like receptor 4 is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on...
- LILRA4LILRA4Leukocyte immunoglobulin-like receptor subfamily A member 4 is a protein that in humans is encoded by the LILRA4 gene....
- LILRA5
- LILRA6
- LILRB1LILRB1Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.-Further reading:...
- LILRB2LILRB2Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.-Further reading:...
- LILRB3LILRB3Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene....
- LILRB4LILRB4Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene....
- LILRB5LILRB5Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene....
- LILRP2
- LRIG2
- LRIT1
- LRRC4LRRC4Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.-Further reading:...
- LSAMP
- MAGMAGIn cryptography, MAG is stream cipher algorithm developed by Rade Vuckovac. It has been submitted to the eSTREAM Project of the eCRYPT network. It has not been selected for focus, nor for consideration in Phase 2; it has been 'archived'....
- MALT1MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a protein that in humans is encoded by the MALT1 gene.-Further reading:...
- MCAM
- MDGA1
- MDGA2MDGA2MDGA2 is a human gene.It has previously been called MAMDC1.MDGA2 is located on chromosome 14.The gene has a homologue in rat and mouse, Mdga2,...
- MERTKMERTKProto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.-External links:*...
- MFAP3
- MIRMirMir was a space station operated in low Earth orbit from 1986 to 2001, at first by the Soviet Union and then by Russia. Assembled in orbit from 1986 to 1996, Mir was the first modular space station and had a greater mass than that of any previous spacecraft, holding the record for the...
- MIRMirMir was a space station operated in low Earth orbit from 1986 to 2001, at first by the Soviet Union and then by Russia. Assembled in orbit from 1986 to 1996, Mir was the first modular space station and had a greater mass than that of any previous spacecraft, holding the record for the...
- MXRA5
- MYBPC3
- MYOM1MYOM1Myomesin-1 is a protein that in humans is encoded by the MYOM1 gene.-Further reading:...
- MYOM3
- NCANCANCA is a three-letter acronym, which may refer to the:* Constitutional Assembly of Zimbabwe* National Campaign for the Arts, a lobbying group for the arts in the United Kingdom...
- NCAM1
- NCAM2
- NEGR1NEGR1Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene....
- NEO1NEO1Neogenin is a protein that in humans is encoded by the NEO1 gene.-Further reading:...
- NFASCNFASCNeurofascin is a protein that in humans is encoded by the NFASC gene.- Function :Neurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development....
- NOPE
- NPHS1
- NPTNNPTNNeuroplastin is a protein that in humans is encoded by the NPTN gene.-Further reading:...
- NRCAMNRCAMNeuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.-Further reading:...
- NRG1
- NTNT- Places and geographical terms :* Northern Territory, Australia* Northwest Territories, Canada* New Territories, an area of land in Hong Kong* Saudi-Iraqi neutral zone, obsolete ISO 3166 code* Netherlands Antilles, FIPS PUB 10-4 territory code...
- NTRK3
- OBSCNOBSCNObscurin is a protein that in humans is encoded by the OBSCN gene.-Interactions:OBSCN has been shown to interact with Titin and ANK1.-Further reading:...
- OBSL1OBSL1Obscurin-like protein 1 is a protein that in humans is encoded by the OBSL1 gene.-External Links:* *...
- OPCMLOPCMLOpioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.-Further reading:...
- PAPLNPAPLNPapilin is a protein that in humans is encoded by the PAPLN gene. Papilin is an extracellular matrix glycoprotein....
- PDGFRAPDGFRAAlpha-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRA gene.-Interactions:PDGFRA has been shown to interact with PDGFRB, PLCG1, Sodium-hydrogen antiporter 3 regulator 1, Cbl gene, CRK, Caveolin 1 and PDGFC.-Further reading:...
- PDGFRBPDGFRBBeta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.-Interactions:PDGFRB has been shown to interact with PTPN11, NCK1, Grb2, Caveolin 1, PDGFRA, Sodium-hydrogen antiporter 3 regulator 1, RAS p21 protein activator 1, CRK, SHC1 and...
- PDGFRL
- PECAM1
- PRODH2
- PSG1
- PSG10PSG10Pregnancy-specific beta-1-glycoprotein 10 is a protein that in humans is encoded by the PSG10 gene.-Further reading:...
- PSG11
- PSG11s'
- PSG2PSG2Pregnancy-specific beta-1-glycoprotein 2 is a protein that in humans is encoded by the PSG2 gene.-Further reading:...
- PSG3PSG3Pregnancy-specific beta-1-glycoprotein 3 is a protein that in humans is encoded by the PSG3 gene.-Further reading:...
- PSG4PSG4Pregnancy-specific beta-1-glycoprotein 4 is a protein that in humans is encoded by the PSG4 gene.-Further reading:...
- PSG5PSG5Pregnancy-specific beta-1-glycoprotein 5 is a protein that in humans is encoded by the PSG5 gene.-Further reading:...
- PSG6PSG6Pregnancy-specific beta-1-glycoprotein 6 is a protein that in humans is encoded by the PSG6 gene.-Further reading:...
- PSG7
- PSG8
- PSG9PSG9Pregnancy-specific beta-1-glycoprotein 9 is a protein that in humans is encoded by the PSG9 gene.-Further reading:...
- PTGFRNPTGFRNProstaglandin F2 receptor negative regulator is a protein that in humans is encoded by the PTGFRN gene. PTGFRN has also been designated as CD315 .-Interactions:PTGFRN has been shown to interact with CD9 and CD81....
- PTK7PTK7Tyrosine-protein kinase-like 7 is an enzyme that in humans is encoded by the PTK7 gene.-Further reading:...
- PTPRDPTPRDReceptor-type tyrosine-protein phosphatase delta is an enzyme that in humans is encoded by the PTPRD gene.- Function :The protein encoded by this gene is a member of the protein tyrosine phosphatase family...
- PTPRKPTPRKReceptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the PTPRK gene.-Interactions:PTPRK has been shown to interact with Beta-catenin and Plakoglobin.-Further reading:...
- PTPRMPTPRMReceptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene.- Function :The protein encoded by this gene is a member of the protein tyrosine phosphatase family. Protein tyrosine phosphatases are protein enzymes that remove phosphate moieties from tyrosine...
- PTPRSPTPRSReceptor-type tyrosine-protein phosphatase S is an enzyme that in humans is encoded by the PTPRS gene.-Interactions:PTPRS has been shown to interact with PTPRD and [liprin-alpha-1]].-Further reading:...
- PTPsigma
- PUNC
- PVRPVRPVR may refer to:*Peak Vehicle Requirement, the number of public transport vehicles required to operate the highest frequency service on a route*Penn Virginia Resources, a mining company* Personal video recorder, also known as a digital video recorder...
- PVRL1PVRL1Poliovirus receptor-related 1 , also known as PVRL1, is a human gene that encodes a protein of immunoglobulin superfamily also considered a member of the nectins . It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail...
- PVRL2PVRL2Poliovirus receptor-related 2 , also known as PVRL2 and CD112 , is a human gene.-External links:...
- PVRL4
- RAGE
- SCN1BSCN1BSodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.-External links:*...
- SDK1
- SDK2SDK2Protein sidekick-2 is a protein that in humans is encoded by the SDK2 gene.-Further reading:...
- SEMA3ASEMA3ASemaphorin-3A is a protein that in humans is encoded by the SEMA3A gene.This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type domain, a PSI domain and a Sema domain...
- SEMA3BSEMA3BSemaphorin-3B is a protein that in humans is encoded by the SEMA3B gene.-Further reading:...
- SEMA3E
- SEMA3FSEMA3FSemaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.-Further reading:...
- SEMA3G
- SEMA4DSEMA4DSemaphorin-4D also known as Cluster of Differentiation 100 , is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.- Function :...
- SIGLEC1
- SIGLEC10SIGLEC10Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.-Further reading:...
- SIGLEC11
- SIGLEC12
- SIGLEC14
- SIGLEC6
- SIGLEC7SIGLEC7Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328 .-Further reading:...
- SIGLEC8SIGLEC8Sialic acid-binding Ig-like lectin 8 is a protein that in humans is encoded by the SIGLEC8 gene....
- SIRPGSIRPGSignal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. SIRPG has also recently been designated CD172G .-Further reading:...
- THY1
- TIE1TIE1Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.- Function :...
- TMIGD1
- TMIGD2
- TTNTTNTTN can refer to:* Tamil Television Network, a former Tamil language satellite channel* Trenton-Mercer Airport* Transient tachypnea of the newborn* Symbol for the gene that encodes the protein Titin...
- TYRO3TYRO3Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.-Interactions:TYRO3 has been shown to interact with PIK3R1 and GAS6.-Further reading:...
- UNC5D
- VCAM1
- VSIG1
- VSIG2
- VSIG4
- hEMMPRIN
- kir3d