V-set domains are Ig-like domains resembling the antibody variable domain. V-set domains are found in diverse protein families, including immunoglobulin light and heavy chains; in several T-cell receptors such as CD2 (Cluster of Differentiation 2), CD4, CD80, and CD86; in myelin membrane adhesion molecules; in junction adhesion molecules (JAM); in tyrosine-protein kinase receptors; and in the programmed cell death protein 1 (PD1).

Subfamilies

• Immunoglobulin V-set, subgroup 
• T-cell surface antigen CD2 

Human proteins containing this domain

ACAM; ACAN

Aggrecan

Aggrecan also known as cartilage-specific proteoglycan core protein or chondroitin sulfate proteoglycan 1 is a protein that in humans is encoded by the ACAN gene. This gene is a member of the aggrecan/versican proteoglycan family...

; ADAMTSL1

ADAMTSL1

ADAMTS-like protein 1 is a protein that in humans is encoded by the ADAMTSL1 gene.-Further reading:...

; AGC1; AMICA1

AMICA1

Junctional adhesion molecule-like is a protein that in humans is encoded by the AMICA1 gene.-Further reading:...

; BCAM

BCAM

Basal cell adhesion molecule is a protein that in humans is encoded by the BCAM gene. BCAM has also recently been designated CD239 .-Interactions:BCAM has been shown to interact with Laminin, alpha 5....

; BCAN

BCAN

Brevican core protein is a protein that in humans is encoded by the BCAN gene.In melanocytic cells BCAN gene expression may be regulated by MITF.-Further reading:...

; BGP

CEACAM1

Carcinoembryonic antigen-related cell adhesion molecule 1 also known as CD66a , is a human gene.-Interactions:...

;
BGPc; BT3.3; BTN1A1

BTN1A1

Butyrophilin subfamily 1 member A1 is a protein that in humans is encoded by the BTN1A1 gene.-Function:Btn1a1 regulates the amount of lipids and size of droplets expressed in milk...

; BTN2A1; BTN2A2

BTN2A2

Butyrophilin subfamily 2 member A2 is a protein that in humans is encoded by the BTN2A2 gene.-Further reading:...

; BTN2A3; BTN3A1

BTN3A1

Butyrophilin subfamily 3 member A1 is a protein that in humans is encoded by the BTN3A1 gene.-Further reading:...

; BTN3A2;
BTN3A3

BTN3A3

Butyrophilin subfamily 3 member A3 is a protein that in humans is encoded by the BTN3A3 gene.-Further reading:...

; BTNL2

BTNL2

Butyrophilin-like protein 2 is a protein that in humans is encoded by the BTNL2 gene.-Further reading:...

; BTNL3; BTNL8; BTNL9; C10orf54

C10orf54

Platelet receptor Gi24 is a protein that in humans is encoded by the C10orf54 gene.-Further reading:...

; C1orf32; C9orf94;
CADM1; CADM2; CADM3

CADM3

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.-Further reading:...

; CADM4; CD2

CD2

CD2 is a cell adhesion molecule found on the surface of T cells and natural killer cells.It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor....

; CD226

CD226

CD226 , PTA1 or DNAM-1 is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.- Structure and function :CD226 is a ~65 kDa glycoprotein expressed on the surface of natural...

; CD274

CD274

Programmed cell death 1 ligand 1 also known as cluster of differentiation or B7 homolog 1 is a protein that in humans is encoded by the CD274 gene....

; CD276

CD276

CD276 is a human protein encoded by the gene....

;
CD300A

CD300A

CD300A is a human gene.-External links:* - The Future of Things article...

; CD300C

CD300C

CMRF35-like molecule 6 is a protein that in humans is encoded by the CD300C gene.-Further reading:...

; CD300D; CD300E; CD300LB; CD300LF

CD300LF

CMRF35-like molecule 1 is a protein that in humans is encoded by the CD300LF gene.-Further reading:...

; CD300LG; CD33

CD33

CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.It binds sialic acids, therefore is a member of the SIGLEC family of lectins....

;
CD3G

CD3G

T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene.-Further reading:...

; CD7

CD7

CD7 is a human protein encoded by the gene.-External links:...

; CD79A

CD79A

CD79a molecule, immunoglobulin-associated alpha, also known as mb-1, is a human gene.The mb-1 gene codes for a phosphoprotein, designated CD79a CD79a molecule, immunoglobulin-associated alpha, also known as mb-1, is a human gene.The mb-1 gene codes for a phosphoprotein, designated CD79a CD79a...

; CD79B

CD79B

CD79b molecule, immunoglobulin-associated beta, also known as CD79B , is a human gene.It is associated with agammaglobulinemia-6.-External links:...

; CD80

CD80

Cluster of Differentiation 80 is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival...

; CD83

CD83

CD83 is a human protein encoded by the gene....

; CD86

CD86

Cluster of Differentiation 86 is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival...

; CD8A

CD8A

CD8a , is a human gene.-Interactions:CD8A has been shown to interact with CD3D, HLA-G and HLA-A.-Further reading:...

;
CD8B; CD8B1; CD96

CD96

CD96 or Tactile is a T cell-specific receptor and shares sequence similarity with CD226 ....

; CEACAM1

CEACAM1

Carcinoembryonic antigen-related cell adhesion molecule 1 also known as CD66a , is a human gene.-Interactions:...

; CEACAM16

CEACAM16

CEACAM16 is a gene which encodes carcinoembryonic antigen....

; CEACAM19

CEACAM19

CEACAM19 is a gene which encodes carcinoembryonic antigen....

; CEACAM21

CEACAM21

CEACAM21 is a gene which encodes carcinoembryonic antigen....

; CEACAM3

CEACAM3

Carcinoembryonic antigen-related cell adhesion molecule 3 also known as CD66d , is a human gene....

;
CEACAM4

CEACAM4

CEACAM4 is a gene which encodes carcinoembryonic antigen....

; CEACAM5

CEACAM5

Carcinoembryonic antigen-related cell adhesion molecule 5 also known as CD66e , is a human gene.-Further reading:...

; CEACAM6

CEACAM6

Carcinoembryonic antigen-related cell adhesion molecule 6 also known as CD66c , is a human gene.-External links:...

; CEACAM7

CEACAM7

Carcinoembryonic antigen-related cell adhesion molecule 7 is a protein that in humans is encoded by the CEACAM7 gene.-Further reading:...

; CEACAM8

CEACAM8

Carcinoembryonic antigen-related cell adhesion molecule 8 also known as CD66b , is a human gene.-Further reading:...

; CHL1

CHL1

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 is a protein that in humans is encoded by the CHL1 gene.CHL1 is a cell adhesion molecule closely related to the L1...

; CREA7-4; CRTAM;
CSF1R; CTLA4; CXADR; ERMAP

ERMAP

Erythroid membrane-associated protein is a protein that in humans is encoded by the ERMAP gene.-Further reading:...

; ESAM; F11R; FCAMR; FCRL2

FCRL2

Fc receptor-like protein 2 is a protein that in humans is encoded by the FCRL2 gene.-Further reading:...

;
FKSG87; GLUDP5

GLUDP5

Glutamate dehydrogenase pseudogene 5, also known as GLUDP5, is a human gene.-Further reading:...

; GPA33

GPA33

Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.-Further reading:...

; HAPLN1

HAPLN1

Hyaluronan and proteoglycan link protein 1 is a protein that in humans is encoded by the HAPLN1 gene.-Interactions:HAPLN1 has been shown to interact with Versican.-Further reading:...

; HAPLN2

HAPLN2

Hyaluronan and proteoglycan link protein 2 also known as brain link protein 1 is a protein that in humans is encoded by the HAPLN2 gene. HAPLN1 codes for a related link protein that is expressed in cartilage while Bral1 is expressed in brain.- Function :Bral1 interacts with versican and brevican...

; HAPLN3; HAPLN4; HAVCR1

HAVCR1

Hepatitis A virus cellular receptor 1 is a protein that in humans is encoded by the HAVCR1 gene.-Further reading:...

;
HEPACAM

HEPACAM

Gene hapaCAM was identified, isolated, characterized and first reported by Dr Shali SHEN et.al. in 2005[1]. The gene encodes a protein hepaCAM of 416 aa, which is a new immunoglobulin-like cell adhesion molecule and a putative tumor suppressor...

; HHLA2; HSPG2; ICOSLG

ICOSLG

ICOS ligand is a protein that in humans is encoded by the ICOSLG gene. ICOSLG has also been designated as CD275 ....

; IGHA1

IGHA1

Ig alpha-1 chain C region is a protein that in humans is encoded by the IGHA1 gene.-Further reading:...

; IGHA2

IGHA2

Ig alpha-2 chain C region is a protein that in humans is encoded by the IGHA2 gene.-Further reading:...

; IGHD

IGHD

Ig delta chain C region is a protein that in humans is encoded by the IGHD gene.-Further reading:...

; IGHG1

IGHG1

Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene.-Further reading:...

;
IGHG3

IGHG3

Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene.-Further reading:...

; IGHM

IGHM

Ig mu chain C region is a protein that in humans is encoded by the IGHM gene.It is associated with agammaglobulinemia-1.-Further reading:...

; IGHV1-69; IGHV4-31; IGHV7-81; IGKC

IGKC

Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes a the constant domain of kappa-type light chains for antibodies. It is found on chromosome 2, in humans, within the Immunoglobulin kappa locus, IGK@.-Further reading:...

; IGKV1-5; IGKV2-24;
IGL@

IGL@

Immunoglobulin lambda locus, also known as IGL@, is a region on human chromosome 22 that contains genes for the lambda light chains of antibodies .- Function :...

; IGLC1; IGLV2-14; IGLV3-21; IGLV3-25; IGLV4-3; IGLV5-52; IGLV6-57;
IGSF11; IGSF2

IGSF2

Immunoglobulin superfamily, member 2 also known as CD101 , is a human gene....

; IGSF3; IGSF6; IGSF8

IGSF8

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.IGSF8 has also been designated as CD316 ....

; IGSF9; IL18R1

IL18R1

The interleukin-18 receptor 1 is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene. IL18R1 is also known as CDw218a .-External links:...

; IREM2;
IREM3; JAM2

JAM2

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322 ....

; JAM3

JAM3

Junctional adhesion molecule C is a protein that in humans is encoded by the JAM3 gene.-Further reading:...

; KDR

Kinase insert domain receptor

Kinase insert domain receptor also known as vascular endothelial growth factor receptor 2 is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309...

; KIRREL

KIRREL

Kin of IRRE-like protein 1 is a protein that in humans is encoded by the KIRREL gene.-Interactions:KIRREL has been shown to interact with Nephrin and Tight junction protein 1.-Further reading:...

; KIRREL2

KIRREL2

Kin of IRRE-like protein 2 is a protein that in humans is encoded by the KIRREL2 gene.-Further reading:...

; KIRREL3

KIRREL3

Kin of IRRE-like protein 3 also known as nin of irregular chiasm-like protein 3 or nephrin-like protein 2 is a protein that in humans is encoded by the KIRREL3 gene....

; LAG3

LAG3

Lymphocyte-activation gene 3, also known as LAG3, is a protein which in humans is encoded by the LAG3 gene. LAG3 has also recently been designated CD223 ....

;
LOC253012; LOC402482; MAG

Myelin-associated glycoprotein

Myelin-associated glycoprotein is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. MAG is believed to be involved in myelination during nerve regeneration....

; MGC33530; MOG

Myelin oligodendrocyte glycoprotein

Myelin Oligodendrocyte Glycoprotein ' is a glycoprotein believed to be important in the process of myelinization of nerves in the central nervous system . In humans this protein is encoded by the MOG gene...

; MPZ; MPZL1

MPZL1

Myelin protein zero-like protein 1 is a protein that in humans is encoded by the MPZL1 gene.-Further reading:...

; MPZL2;
MXRA8; MYBPC3; NCA

CEACAM6

Carcinoembryonic antigen-related cell adhesion molecule 6 also known as CD66c , is a human gene.-External links:...

; NCR2

NCR2

Natural cytotoxicity triggering receptor 2 is a protein that in humans is encoded by the NCR2 gene. NCR2 has also been designated as CD336 .-Further reading:-External links:...

; NCR3

NCR3

Natural cytotoxicity triggering receptor 3 is a protein that in humans is encoded by the NCR3 gene. NCR3 has also been designated as CD337 .-External links:...

; NPHS1; OBSL1

OBSL1

Obscurin-like protein 1 is a protein that in humans is encoded by the OBSL1 gene.-External Links:* *...

; OPCML

OPCML

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.-Further reading:...

;
P0; PDCD1; PIGR; PILRA; PILRB

PILRB

Paired immunoglobulin-like type 2 receptor beta is a protein that in humans is encoded by the PILRB gene.-Further reading:...

; PRODH2; PSG1; PSG10

PSG10

Pregnancy-specific beta-1-glycoprotein 10 is a protein that in humans is encoded by the PSG10 gene.-Further reading:...

;
PSG11; PSG11s'; PSG2

PSG2

Pregnancy-specific beta-1-glycoprotein 2 is a protein that in humans is encoded by the PSG2 gene.-Further reading:...

; PSG3

PSG3

Pregnancy-specific beta-1-glycoprotein 3 is a protein that in humans is encoded by the PSG3 gene.-Further reading:...

; PSG4

PSG4

Pregnancy-specific beta-1-glycoprotein 4 is a protein that in humans is encoded by the PSG4 gene.-Further reading:...

; PSG5

PSG5

Pregnancy-specific beta-1-glycoprotein 5 is a protein that in humans is encoded by the PSG5 gene.-Further reading:...

; PSG6

PSG6

Pregnancy-specific beta-1-glycoprotein 6 is a protein that in humans is encoded by the PSG6 gene.-Further reading:...

; PSG7;
PSG8; PSG9

PSG9

Pregnancy-specific beta-1-glycoprotein 9 is a protein that in humans is encoded by the PSG9 gene.-Further reading:...

; PTGFRN

PTGFRN

Prostaglandin F2 receptor negative regulator is a protein that in humans is encoded by the PTGFRN gene. PTGFRN has also been designated as CD315 .-Interactions:PTGFRN has been shown to interact with CD9 and CD81....

; PTPN1L; PVR

CD155

CD155 also known as the poliovirus receptor is a protein that in humans is encoded by the PVR gene.- Function :CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily...

; PVRL1

PVRL1

Poliovirus receptor-related 1 , also known as PVRL1, is a human gene that encodes a protein of immunoglobulin superfamily also considered a member of the nectins . It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail...

; PVRL2

PVRL2

Poliovirus receptor-related 2 , also known as PVRL2 and CD112 , is a human gene.-External links:...

; PVRL3

PVRL3

Poliovirus receptor-related 3 , also known as PVRL3 and CD113 , is a human gene.-Interactions:PVRL3 has been shown to interact with MLLT4, PARD3, and PTPmu ....

;
PVRL4; SCN2B

SCN2B

Sodium channel subunit beta-2 is a protein that in humans is encoded by the SCN2B gene....

; SCN3B

SCN3B

Sodium channel subunit beta-3 is a protein that in humans is encoded by the SCN3B gene.-External links:*...

; SCN4B

SCN4B

Sodium channel, also known as SCN4B is a protein which in humans is encoded by the SCN4B gene.SCN4B is a sodium channel associated with long QT syndrome.-External links:*...

; SEMA3D; SIGLEC1; SIGLEC10

SIGLEC10

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.-Further reading:...

; SIGLEC11;
SIGLEC12; SIGLEC14; SIGLEC15; SIGLEC6; SIGLEC7

SIGLEC7

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328 .-Further reading:...

; SIGLEC8

SIGLEC8

Sialic acid-binding Ig-like lectin 8 is a protein that in humans is encoded by the SIGLEC8 gene....

; SIGLEC9

SIGLEC9

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.-Further reading:...

; SIRPA

Sirpa

Sirpa is a village development committee in Rolpa District in the Rapti Zone of north-eastern Nepal. At the time of the 1991 Nepal census it had a population of 5258 people living in 963 individual households....

;
SIRPB1

SIRPB1

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene. SIRPB1 has also recently been designated CD172B .-Further reading:...

; SIRPD; SIRPG

SIRPG

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. SIRPG has also recently been designated CD172G .-Further reading:...

; SISP1; SLAMF6

SLAMF6

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.-Further reading:...

; SLAMF7

SLAMF7

SLAM family member 7 is a protein that in humans is encoded by the SLAMF7 gene.-Further reading:...

; TAPBPL; TCRA;
TCRB; TIMD4; TRA@

TRA@

T-cell receptor alpha chain C region is a protein that in humans is encoded by the TRA@ gene.-Further reading:...

; TRAV20; TRBC1; TRBV19; TRBV3-1; TRBV5-4;
TRBV7-2; TRDV2; TREM1

TREM1

Triggering receptor expressed on myeloid cells 1 is a protein that in humans is encoded by the TREM1 gene.-Further reading:...

; TREM2

TREM2

Triggering receptor expressed on myeloid cells 2 is a protein that in humans is encoded by the TREM2 gene.-External links:* -Further reading:...

; TREML1

TREML1

Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene.-Further reading:...

; TREML2; TREML4; TRGV3;
TRGV5; TRGV7; TRGV9

TRGV9

T cell receptor gamma variable 9, also known as TRGV9, is a human gene.-Further reading:...

; VCAM1; VCAN; VPREB1

VPREB1

Immunoglobulin iota chain is a protein that in humans is encoded by the VPREB1 gene. VPREB1 has also recently been designated CD179A .-Further reading:...

; VPREB3

VPREB3

Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.-Further reading:...

; VSIG1;
VSIG2; VSIG4; VSIG9; VSTM1; VSTM2; VTCN1

VTCN1

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.-Further reading:...

;