History of anorexia nervosa
Encyclopedia
The history of anorexia nervosa begins with descriptions of religious fasting dating from the Hellenistic era
Hellenistic civilization
Hellenistic civilization represents the zenith of Greek influence in the ancient world from 323 BCE to about 146 BCE...

  and continuing into the medieval period. A number of well known historical figures, including Catherine of Siena
Catherine of Siena
Saint Catherine of Siena, T.O.S.D, was a tertiary of the Dominican Order, and a Scholastic philosopher and theologian. She also worked to bring the papacy of Gregory XI back to Rome from its displacement in France, and to establish peace among the Italian city-states. She was proclaimed a Doctor...

 and Mary, Queen of Scots are believed to have suffered from the condition.

The earliest medical descriptions of anorexic illnesses are generally credited to English physician Richard Morton
Richard Morton (physician)
Richard Morton was an English physician who was the first to state that tubercles were always present in the tuberculosis disease of the lungs. In Morton's time, this wasting disease was termed consumption, or by its Greek name of phthisis...

, in 1689.

However it was not until the late 19th century that anorexia nervosa was to be widely accepted by the medical profession as a recognised condition. In 1873, Sir William Gull, one of Queen Victoria’s personal physicians, published a seminal paper which established the term anorexia nervosa and provided a number of detailed case descriptions and treatments. In the same year, French physician Ernest-Charles Lasègue
Charles Lasègue
Charles Lasègue, full name Ernest-Charles Lasègue was a French physician who was born in Paris. In 1847 he received his medical doctorate from the University of Paris, and during the following year was sent to Southern Russia by the French government to research an epidemic of cholera...

 similarly published details of a number of cases in a paper entitled De l’Anorexie Histerique.

Awareness of the condition was largely limited to the medical profession until the latter part of the 20th century, when German-American psychoanalyst Hilde Bruch
Hilde Bruch
Hilde Bruch was a German-born American psychoanalyst, known foremost for her work on eating disorders and obesity.Bruch emigrated to the United States in 1934...

 published her popular work The Golden Cage: the Enigma of Anorexia Nervosa in 1978. This book created a wider awareness of anorexia nervosa among lay readers. A further important event was the death of the popular singer Karen Carpenter
Karen Carpenter
Karen Anne Carpenter was an American singer and drummer. She and her brother, Richard, formed the 1970s duo The Carpenters. She was a drummer of exceptional skill, but she is best remembered for her vocal performances of idealistic romantic ballads of true love...

 in 1983, which prompted widespread ongoing media coverage of eating disorders.

Etymology

The term anorexia nervosa was established in 1873 by Queen Victoria’s personal physician, Sir William Gull. The term anorexia is of Greek origin: an- (ἀν-, prefix denoting negation) and orexis (ὄρεξις, "appetite"), thus translating to "nervous absence of appetite".

In an earlier address, in 1868, Gull referred to the condition as Apepsia hysterica, but subsequently amended this to Anorexia hysterica and then to Anorexia nervosa. In a paper published in 1873, French physician Ernest-Charles Lasègue published a paper entitled De l’Anorexie Histerique. The use, and subsequent abandonment, of the term hysterica is of interest, since in the Victorian era the term was interpreted as applying to female behaviour. In 1873, Gull wrote:

13th and 14th Centuries: Saint Catherine of Siena & Saint Hedwig of Andechs or Silesia

Of interest in terms of anorexia nervosa is the medieval practice of self-starvation by women, including some young women, in the name of religious piety and purity. This is sometimes referred to as anorexia mirabilis
Anorexia mirabilis
Anorexia mirabilis literally means "miraculous lack of appetite". It refers almost exclusively to women and girls of the Middle Ages who would starve themselves, sometimes to the point of death, in the name of God...

. By the thirteenth century, it was increasingly common for women to participate in religious life and to even be named as saints by the Catholic Church. Many women who ultimately became saints engaged in self-starvation, including Saint Hedwig of Andechs in the thirteenth century and Catherine of Siena
Catherine of Siena
Saint Catherine of Siena, T.O.S.D, was a tertiary of the Dominican Order, and a Scholastic philosopher and theologian. She also worked to bring the papacy of Gregory XI back to Rome from its displacement in France, and to establish peace among the Italian city-states. She was proclaimed a Doctor...

 in the fourteenth century. By the time of Catherine of Siena, however, the Church became concerned about extreme fasting as an indicator of spirituality and as a criteria for sainthood. Indeed, Catherine of Siena was told by Church authorities to pray that she would be able to eat again, but was unable to give up fasting.

1556: Mary, Queen of Scots

Mary Stewart, known as Mary, Queen of Scots, was brought up as a child in the court of Henry II of France
Henry II of France
Henry II was King of France from 31 March 1547 until his death in 1559.-Early years:Henry was born in the royal Château de Saint-Germain-en-Laye, near Paris, the son of Francis I and Claude, Duchess of Brittany .His father was captured at the Battle of Pavia in 1525 by his sworn enemy,...

. Her medical history is documented in some detail thanks to the accounts of various ambassadors who sent reports back to their respective sovereigns. It is known, for example, that she had measles when she was five, rubella when she was seven, dysentery and malaria when she was 14 and smallpox when she was 15.

She also had an unnamed illness as a teenager that some now believe to have been anorexia nervosa. Her condition is described as involving weight loss, uneven appetite, vomiting and diarrhoea, pallor, fainting fits and breathing difficulties. She was, however, physically active throughout the illness; she continued to ride on horseback and dance in the evenings at the same time as these symptoms were observed.

1613: Jane Balan – the “French fasting girl of Confolens”

The case of Jane Balans, the “French Fasting Girl of Confolens
Confolens
Confolens is a commune in southwestern France. It is one of the two sub-prefecture of the Charente department.Confolens is the administrative center of a largely rural district, which has seen the development of tourism in recent years.-Geography:...

,” was described in 1613 by Pedro Mexio. He noted that she “lived without receiving meat or drink for at least three years.” The condition began on 15 February 1599, when Jane Balans was around 10 years old. After suffering a fever and vomiting, she became withdrawn and weakened, refusing all food.

Contemporary superstition blamed the wicked power of an apple given her by an old woman some months prior to the start of the condition; Mexio diagnosed the case as a “drying up of the liver and of all the parts serving to nourishment due to hurtful humours”

1689: Richard Morton’s case descriptions

Two early medical descriptions of a syndrome involving loss of appetite and extreme wasting without any evidence of known disease are provided by the English physician Richard Morton
Richard Morton (physician)
Richard Morton was an English physician who was the first to state that tubercles were always present in the tuberculosis disease of the lungs. In Morton's time, this wasting disease was termed consumption, or by its Greek name of phthisis...

 in 1689. He provided two case descriptions in his “Phthisiologia: Or, a Treatise of Consumptions,” a 1694 translation of his 1689 work “Phthisiologica, seu exercitationes de phthisi libris comprehensae. Totumque opus variis histories illustratum.” Morton described these cases as “Nervous Atrophy, or Consumption.” The first, in 1684, involved a “Mr Duke’s daughter in St Mary Axe
St Mary Axe
St Mary Axe was a medieval parish in London whose name survives on the street it formerly occupied, St Mary Axe. The church itself was demolished in 1561 and its parish united with that of St Andrew Undershaft, which is on the corner of St Mary Axe and Leadenhall Street...

” (a street in the City of London
City of London
The City of London is a small area within Greater London, England. It is the historic core of London around which the modern conurbation grew and has held city status since time immemorial. The City’s boundaries have remained almost unchanged since the Middle Ages, and it is now only a tiny part of...

). He writes of her thus:
The girl consulted Dr Morton only after she had been ill for two years, and then only because she experienced frequent fainting fits. Morton described her as a “Skeleton only clad in skin.” He noted her “continual poring upon Books” despite her condition and that she was indifferent to the extreme cold of an unusually severe winter. She refused any treatment (which consisted of the likes of cloves bruised in wine, and stomach plasters). She died three months later.

The other patient was described as “The Son of the Reverend Minister Steele.” He began to fast at the age of 16. Morton attributed his “want of appetite” to “studying too hard” as well as the “passions of his mind.” Morton was more successful with this patient, who followed the doctor’s advice to abandon his studies and move to the country, take up riding and drink plenty of milk, whereupon he “recovered his health in great measure.”

1790: Robert Willan’s case description

Robert Willan
Robert Willan
Robert Willan was an English physician and the founder of dermatology as a medical specialty. He received his MD at Edinburgh in 1780 and was elected a Fellow of the Royal Society in 1809...

 was an English physician based in London who is credited with founding dermatology as a medical speciality. He is one of the first to describe the symptoms of extreme weight loss in males, in his paper “A Remarkable Case of Abstinence,” published in Medical Communications in 1790. This describes the case of a young Englishman who died in 1786 after fasting for 78 days. He wrote:

1859: Louis-Victor Marcé’s case descriptions

Louis-Victor Marcé (1828–1864), a Paris-based French physician, published a number of case studies describing psychiatric disorders of women during and following pregnancy. His case descriptions included that of a patient displaying the symptoms of anorexia nervosa in 1859. In 1860, Marcé wrote:

1868: William Gull (address to the British Medical Association)

In 1868, William Gull was a leading British physician based in London. That year, he described his observations of an emaciated condition in young women in an address to the British Medical Association
British Medical Association
The British Medical Association is the professional association and registered trade union for doctors in the United Kingdom. The association does not regulate or certify doctors, a responsibility which lies with the General Medical Council. The association’s headquarters are located in BMA House,...

 (BMA) in Oxford. He observed that the causes of the condition were unknown, but that the subjects affected were "mostly of the female sex, and chiefly between the ages of sixteen and twenty three" although he also qualified this statement by adding that he had occasionally seen it in males of the same age.

The Lancet
The Lancet
The Lancet is a weekly peer-reviewed general medical journal. It is one of the world's best known, oldest, and most respected general medical journals...

 (the BMA’s in-house journal) published the following extract from Gull's address:

1873: Sir William Gull’s "Anorexia Nervosa" paper

By 1873, Sir William Gull had been made a Baronet  and was one of four Physicians-in-Ordinary to Queen Victoria. In that year, he published his seminal work “Anorexia Nervosa (Apepsia Hysterica, Anorexia Hysterica)", in which he describes the three cases of Miss A, Miss B, and a third unnamed case. In 1887, he also recorded the case of Miss K, in what was to be the last of his medical papers to be published.

Sir William Gull writes that Miss A was referred to him on 17 January 1866. She was aged 17 and was greatly emaciated, having lost 33 pounds. Her weight at this time was 5 stones 12 pounds (82 pounds); her height was 5 ft 5 inches. Gull records that most of her physical condition was normal, with healthy respiration, heart sounds and pulse; no vomiting nor diarrhoa; clean tongue and normal urine. The condition was that of simple starvation, with total refusal of animal food and almost total refusal of everything else.
Gull prescribed various remedies (including preparations of cinchona, biochloride of mercury, syrup of iodide of iron, syrup of phosphate of iron, citrate of quinine) and variations in diet without noticeable success. He noted occasional voracious appetite for very brief periods, but states that these were very rare and exceptional. He also records that she was frequently restless and active and notes that this was a "striking expression of the nervous state, for it seemed hardly possible that a body so wasted could undergo the exercise which seemed agreeable".

In Gull's published medical papers, images of Miss A are shown that depict her appearance before and after treatment (right). Gull notes her aged appearance at age 17:

Miss A remained under Gull's observation from January 1866 to March 1868, by which time she seemed to have made a full recovery, having gained in weight from 82 to 128 pounds.}}

Miss B was referred to Gull on 8 October 1868, aged 18, as a case of suspected tuberculosis
Tuberculosis
Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...

. Gull noted that her emaciated appearance was more extreme than normally occurs in tubercular cases. His physical examination of her chest and abdomen discovered nothing abnormal, but he recorded a "peculiar restlessness" that was difficult to control. The mother advised that "She is never tired". Gull was struck by the similarity of the case to that of Miss A, even to the detail of the pulse and respiration observations.

Miss B was treated by Gull until 1872, by which time a noticeable recovery was underway and eventually complete. Gull admits in his medical papers that the medical treatment probably did not contribute much to the recovery, consisting, as in the former case, of various tonics and a nourishing diet.

Although the cases of Miss A and Miss B resulted in recovery, Gull states that he observed at least one fatality as a result of anorexia nervosa. He states that the post mortem revealed no physical abnormalities other than thrombosis
Thrombosis
Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets and fibrin to form a blood clot to prevent blood loss...

 of the femoral veins. Death appeared to have resulted from starvation alone.

1873: Ernest-Charles Lasègue

Ernest-Charles Lasègue
Charles Lasègue
Charles Lasègue, full name Ernest-Charles Lasègue was a French physician who was born in Paris. In 1847 he received his medical doctorate from the University of Paris, and during the following year was sent to Southern Russia by the French government to research an epidemic of cholera...

 was a French physician who practised at the Salpêtrière
Pitié-Salpêtrière Hospital
The Pitié-Salpêtrière Hospital is a teaching hospital located in Paris, France. Part of the Assistance publique - Hôpitaux de Paris, it is one of Europe's largest hospitals...

, Pitié and Necker hospitals. From 1869, he was a professor of clinical medicine at Hôpital Necker.

In 1873, Lasègue published a paper entitled "De l’Anorexie Histerique" in the Archives générales de Médecin. Later that year, a translated version of the paper was published in the British Medical Times.

Lasègue began the article by noting the importance of recognizing hysterical anorexia as a diagnostic entity, and then described the progression of the illness. He proposed the hypothesis that at the onset of the disease, lack of appetite originates from a wish to avoid pain. After this, a passage was deleted from the translation which described 'the paradoxical liveliness' of the anorexic. Lasègue contrasted anorexic behaviour to the behaviour of people forced into starvation during the great famine in Paris. Lasegue then described the downward spiral of the anorexic, characterized by indifference, disgust, aversion, and eventually starvation, ill health and possible death.

Lasègue's paper contrasts with Gull's work by its focus on the psychological symptoms and examination of the role of parental influences and family interactions. He wrote about some of the family dynamics inherent in anorexic families, and provided a detailed description of a scene in which relatives try to persuade an anorexic to eat.

In an addendum to his Anorexia Nervosa paper, Sir William Gull provides the following comment on Lasègue's work:

Recent History

Although the medical facts of anorexia nervosa have been documented since the 1870s, public awareness of the condition was limited until the second half of the 20th century. The concept of obsession with body image as a motivating factor for excessive fasting did not emerge until the mid-1960s,
and it was not until 1980 that body image disturbance was formally included as a diagnostic criterion in the Diagnostic and Statistical Manual of Mental Disorders
Diagnostic and Statistical Manual of Mental Disorders
The Diagnostic and Statistical Manual of Mental Disorders is published by the American Psychiatric Association and provides a common language and standard criteria for the classification of mental disorders...

 published by the American Psychiatric Association
American Psychiatric Association
The American Psychiatric Association is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the most influential worldwide. Its some 38,000 members are mainly American but some are international...


Hilde Bruch research and publications

Hilde Bruch
Hilde Bruch
Hilde Bruch was a German-born American psychoanalyst, known foremost for her work on eating disorders and obesity.Bruch emigrated to the United States in 1934...

 (March 11, 1904 - December 15, 1984) was a German-born American
German American
German Americans are citizens of the United States of German ancestry and comprise about 51 million people, or 17% of the U.S. population, the country's largest self-reported ancestral group...

 psychoanalyst, who practised at Baylor College of Medicine
Baylor College of Medicine
Baylor College of Medicine, located in the Texas Medical Center in Houston, Texas, USA, is a highly regarded medical school and leading center for biomedical research and clinical care...

, Houston
Houston, Texas
Houston is the fourth-largest city in the United States, and the largest city in the state of Texas. According to the 2010 U.S. Census, the city had a population of 2.1 million people within an area of . Houston is the seat of Harris County and the economic center of , which is the ...

 in the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...

. Her early career focussed on obesity; but from the early 1960s she increasingly turned her attention to anorexia nervosa and its underlying causes. Bruch’s 1973 work Eating Disorders: Obesity, Anorexia Nervosa, and the Person Within is considered a seminal work on the subject and was the first of several works that documented her work with anorexic subjects.

Her best known work was The Golden Cage: the Enigma of Anorexia Nervosa, published in 1978. This book drew on material in Eating Disorders in a publication aimed at a lay readership. It sold 150,000 copies and is recognized as one of the earliest publications that created a wider awareness of anorexia nervosa beyond the medical profession.

Death of Karen Carpenter

Karen Carpenter
Karen Carpenter
Karen Anne Carpenter was an American singer and drummer. She and her brother, Richard, formed the 1970s duo The Carpenters. She was a drummer of exceptional skill, but she is best remembered for her vocal performances of idealistic romantic ballads of true love...

was a popular American vocal and drummer musician. Her death on February 4, 1983, was attributed to heart failure as a consequence of anorexia nervosa.

Public awareness of anorexia nervosa and other eating disorders was transformed by Karen Carpenter’s death. Her young age (32) coupled with her fame as an entertainer captured public attention and received extensive media coverage. The sympathetic reporting of her illness prompted other celebrities, such as Jane Fonda and Lynn Redgrave, to come forward and share their experiences.

Karen Carpenter’s brother and singing partner, Richard Carpenter, established a fund dedicated to his sister’s memory for research into anorexia nervosa.
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