Heinz Falk
Encyclopedia
Heinz Falk is professor emeritus for organic chemistry
at Johannes Kepler University of Linz
and
editor
of "Progress in the Chemistry of Organic Natural Compounds".
His research is focused on structural analysis, synthesis
, stereochemistry
and photochemistry
of plant and animal photosensitizing and photosensory pigments, such as hypericin
.
, Austria
, went to elementary school in Statzendorf
and completed middle school in Krems an der Donau. After moving to Vienna
in 1953 he completed a three-year program at HBLVA for Chemical Industry, Rosensteingasse and completed his high-school diploma in 1959 through classes at an evening school, where he met his future wife, Rotraud Falk (née Strohbach).
at the University of Vienna
starting in 1959 and completed his dissertation under his doctoral
advisor, Karl Schlögl
, in 1966. In 1971 Falk spent a year abroad to study at ETH Zürich
. Upon his return to Vienna
in 1972 he attained habilitation
for organic chemistry
at the University of Vienna
.
Starting in 1966 Falk was an assistant at the Institute of Organic Chemistry at the University of Vienna
. In 1975 he was promoted to associate professor
of physical organic chemistry
at the University of Vienna
. In the summer of 1978 Falk was invited to speak at the Gordon Research Conference
in Wolfeboro.
1979–present: Johannes Kepler University of Linz
In 1979 Falk received a call to become full professor
of organic chemistry
at Johannes Kepler University of Linz
, where he founded the new
Institute of Organic Chemistry. From 1989 through 1991 he was elected Dean
of the Faculty
of Engineering and Natural Sciences (TNF) at Johannes Kepler University of Linz
. In 2005 Falk was ranked #3 among the "Top 10" scientists in Upper Austria
by the newspaper "OÖ Nachrichten".
, stereochemistry
and photochemistry
of plant and animal photosensitizing and photosensory pigments. The main group of compounds covered in his work are pigments derived from the fundamental phenanthro[1,10,9,8-opqra]perylene-7,14-dione chromophore with natural pigments like hypericin
, stentorin, the fringelites, the gymnochromes, and blepharismin. In addition, he is focusing on hemin-analogous corrphycene derivatives (e.g. as potential blood substitutes
and heme oxygenase
blocker) as well as on other natural compounds such as the natural sun blocker urocanic acid
. Furthermore, research on applied problems of industrial relevance, like oxidation, ozonization, non natural amino acids and catalysis have been pursued.
Organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions, and preparation of carbon-based compounds, hydrocarbons, and their derivatives...
at Johannes Kepler University of Linz
Johannes Kepler University of Linz
The Johannes Kepler University of Linz is a public institution of higher education in Linz, the capital of Upper Austria...
and
editor
Editor in chief
An editor-in-chief is a publication's primary editor, having final responsibility for the operations and policies. Additionally, the editor-in-chief is held accountable for delegating tasks to staff members as well as keeping up with the time it takes them to complete their task...
of "Progress in the Chemistry of Organic Natural Compounds".
His research is focused on structural analysis, synthesis
Organic synthesis
Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions. Organic molecules can often contain a higher level of complexity compared to purely inorganic compounds, so the synthesis of organic compounds has...
, stereochemistry
Stereochemistry
Stereochemistry, a subdiscipline of chemistry, involves the study of the relative spatial arrangement of atoms within molecules. An important branch of stereochemistry is the study of chiral molecules....
and photochemistry
Photochemistry
Photochemistry, a sub-discipline of chemistry, is the study of chemical reactions that proceed with the absorption of light by atoms or molecules.. Everyday examples include photosynthesis, the degradation of plastics and the formation of vitamin D with sunlight.-Principles:Light is a type of...
of plant and animal photosensitizing and photosensory pigments, such as hypericin
Hypericin
Hypericin is a naphthodianthrone, a red-colored anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum . Hypericin is believed to act as an antibiotic and non-specific kinase inhibitor...
.
Early life
Heinz Falk was born April 29, 1939 in Sankt PöltenSankt Pölten
Sankt Pölten is the capital city of the State of Lower Austria in northeast Austria. With inhabitants , it is Lower Austria's largest city...
, Austria
Austria
Austria , officially the Republic of Austria , is a landlocked country of roughly 8.4 million people in Central Europe. It is bordered by the Czech Republic and Germany to the north, Slovakia and Hungary to the east, Slovenia and Italy to the south, and Switzerland and Liechtenstein to the...
, went to elementary school in Statzendorf
Statzendorf
Statzendorf is a municipality in the district of Sankt Pölten-Land in Lower Austria, Austria....
and completed middle school in Krems an der Donau. After moving to Vienna
Vienna
Vienna is the capital and largest city of the Republic of Austria and one of the nine states of Austria. Vienna is Austria's primary city, with a population of about 1.723 million , and is by far the largest city in Austria, as well as its cultural, economic, and political centre...
in 1953 he completed a three-year program at HBLVA for Chemical Industry, Rosensteingasse and completed his high-school diploma in 1959 through classes at an evening school, where he met his future wife, Rotraud Falk (née Strohbach).
Marriage and children
Heinz Falk is married to Rotraud Falk since 1966 and they have one son:- Alexander Falk (August 13, 1967) is the CEO of AltovaAltovaFounded in 1992, Altova is a commercial software development company with headquarters in Beverly, MA, USA and Vienna, Austria that produces integrated XML, database, UML, and data management software development tools.-Products:Altova’s products include:...
.
Education
Heinz Falk studied chemistryChemistry
Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
at the University of Vienna
University of Vienna
The University of Vienna is a public university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world...
starting in 1959 and completed his dissertation under his doctoral
Doctorate
A doctorate is an academic degree or professional degree that in most countries refers to a class of degrees which qualify the holder to teach in a specific field, A doctorate is an academic degree or professional degree that in most countries refers to a class of degrees which qualify the holder...
advisor, Karl Schlögl
Karl Schlögl
Karl Schlögl was professor of organic chemistry at the University of Vienna and secretary as well as vice-president of the Austrian Academy of Sciences.-Biography:Karl Schlögl was born October 5, 1924 in Vienna...
, in 1966. In 1971 Falk spent a year abroad to study at ETH Zürich
ETH Zurich
The Swiss Federal Institute of Technology Zurich or ETH Zürich is an engineering, science, technology, mathematics and management university in the City of Zurich, Switzerland....
. Upon his return to Vienna
Vienna
Vienna is the capital and largest city of the Republic of Austria and one of the nine states of Austria. Vienna is Austria's primary city, with a population of about 1.723 million , and is by far the largest city in Austria, as well as its cultural, economic, and political centre...
in 1972 he attained habilitation
Habilitation
Habilitation is the highest academic qualification a scholar can achieve by his or her own pursuit in several European and Asian countries. Earned after obtaining a research doctorate, such as a PhD, habilitation requires the candidate to write a professorial thesis based on independent...
for organic chemistry
Organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions, and preparation of carbon-based compounds, hydrocarbons, and their derivatives...
at the University of Vienna
University of Vienna
The University of Vienna is a public university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world...
.
Career
1966-1979: University of ViennaUniversity of Vienna
The University of Vienna is a public university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world...
Starting in 1966 Falk was an assistant at the Institute of Organic Chemistry at the University of Vienna
University of Vienna
The University of Vienna is a public university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world...
. In 1975 he was promoted to associate professor
Professor
A professor is a scholarly teacher; the precise meaning of the term varies by country. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences; a teacher of high rank...
of physical organic chemistry
Physical organic chemistry
Physical organic chemistry is the study of the interrelationships between structure and reactivity in organic molecules. It can be seen as the study of organic chemistry using tools of physical chemistry such as chemical equilibrium, chemical kinetics, thermochemistry, and quantum chemistry...
at the University of Vienna
University of Vienna
The University of Vienna is a public university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world...
. In the summer of 1978 Falk was invited to speak at the Gordon Research Conference
Gordon Research Conferences
Gordon Research Conferences are international scientific conferences organized by a non-profit organization of the same name. The conference topics cover frontier research in the biological, chemical, and physical sciences, and their related technologies. The conferences have been held since...
in Wolfeboro.
1979–present: Johannes Kepler University of Linz
Johannes Kepler University of Linz
The Johannes Kepler University of Linz is a public institution of higher education in Linz, the capital of Upper Austria...
In 1979 Falk received a call to become full professor
Professor
A professor is a scholarly teacher; the precise meaning of the term varies by country. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences; a teacher of high rank...
of organic chemistry
Organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions, and preparation of carbon-based compounds, hydrocarbons, and their derivatives...
at Johannes Kepler University of Linz
Johannes Kepler University of Linz
The Johannes Kepler University of Linz is a public institution of higher education in Linz, the capital of Upper Austria...
, where he founded the new
Institute of Organic Chemistry. From 1989 through 1991 he was elected Dean
Dean (education)
In academic administration, a dean is a person with significant authority over a specific academic unit, or over a specific area of concern, or both...
of the Faculty
Faculty (university)
A faculty is a division within a university comprising one subject area, or a number of related subject areas...
of Engineering and Natural Sciences (TNF) at Johannes Kepler University of Linz
Johannes Kepler University of Linz
The Johannes Kepler University of Linz is a public institution of higher education in Linz, the capital of Upper Austria...
. In 2005 Falk was ranked #3 among the "Top 10" scientists in Upper Austria
Upper Austria
Upper Austria is one of the nine states or Bundesländer of Austria. Its capital is Linz. Upper Austria borders on Germany and the Czech Republic, as well as on the other Austrian states of Lower Austria, Styria, and Salzburg...
by the newspaper "OÖ Nachrichten".
Research interests
Falk's main research area is the structural analysis, synthesisOrganic synthesis
Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions. Organic molecules can often contain a higher level of complexity compared to purely inorganic compounds, so the synthesis of organic compounds has...
, stereochemistry
Stereochemistry
Stereochemistry, a subdiscipline of chemistry, involves the study of the relative spatial arrangement of atoms within molecules. An important branch of stereochemistry is the study of chiral molecules....
and photochemistry
Photochemistry
Photochemistry, a sub-discipline of chemistry, is the study of chemical reactions that proceed with the absorption of light by atoms or molecules.. Everyday examples include photosynthesis, the degradation of plastics and the formation of vitamin D with sunlight.-Principles:Light is a type of...
of plant and animal photosensitizing and photosensory pigments. The main group of compounds covered in his work are pigments derived from the fundamental phenanthro[1,10,9,8-opqra]perylene-7,14-dione chromophore with natural pigments like hypericin
Hypericin
Hypericin is a naphthodianthrone, a red-colored anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum . Hypericin is believed to act as an antibiotic and non-specific kinase inhibitor...
, stentorin, the fringelites, the gymnochromes, and blepharismin. In addition, he is focusing on hemin-analogous corrphycene derivatives (e.g. as potential blood substitutes
Blood substitutes
A blood substitute is a substance used to mimic and fulfill some functions of biological blood, usually in the oxygen-carrying sense...
and heme oxygenase
Oxygenase
An oxygenase is any enzyme that oxidizes a substrate by transferring the oxygen from molecular oxygen O2 to it. The oxygenases form a class of oxidoreductases; their EC number is EC 1.13 or EC 1.14....
blocker) as well as on other natural compounds such as the natural sun blocker urocanic acid
Urocanic acid
Urocanic acid is an intermediate in the catabolism of L-histidine.-Metabolism:It is formed from L-histidine through the action of histidine ammonialyase by elimination of ammonium....
. Furthermore, research on applied problems of industrial relevance, like oxidation, ozonization, non natural amino acids and catalysis have been pursued.
Scientific Articles
- H. Marko, N. Müller und H. Falk, Nuclear Magnetic Resonance Investigations of the Biliverdin/Apomyoglobin Complex. Eur. J. Biochem. 193, 573 (1990)
- H. Falk, H. Marko, N. Müller, W. Schmitzberger und H. Stumpe, Reconstitution of Apomyoglobin with Bile Pigments. Monatsh. Chem. 121, 893 (1990)
- H. Falk, H. Marko, N. Müller und W. Schmitzberger, On the Chemistry of Pyrrole Pigments 87.Mitt.: The Apomyoglobin Heme Pocket as a Reaction Vessel in Bile Pigment Chemistry. Monatsh. Chem. 121, 903 (1990)
- H. Falk und H. Marko, Reduction of a Bilindione-10-Thiol-Adduct as a Model for the Reduction Step of the Biliverdin Reductase System. Monatsh. Chem. 122, 319 (1991)
- U. Wagner, C. Kratky, H. Falk und H. Woess, Crystal Structure and Conformation of 10-Aryl-bilatrienes-abc. Monatsh. Chem. 122, 749 (1991)
- H. Falk und G. Schoppel, A Synthesis of Emodin Anthrone. Monatsh. Chem. 122, 739 (1991)
- H. Falk and W. Schmitzberger, On the Nature of "Soluble" Hypericin in Hypericum Species. Monatsh. Chem., 123, 731 (1992)
- H. Falk and D. Hemmer, On the Chemistry of Pyrrole Pigments, 88. Mitt.: Nonlinear Optical Properties of Linear Oligopyrroles. Monatsh. Chem. 123, 779 (1992)
- H. Falk and G. Schoppel, On the Synthesis of Hypericin by Oxidative Trimethylemodin Anthrone and Emodin Anthrone Dimerization: Isohypericin. Monatsh. Chem. 123, 931 (1992)
- H. Falk and W. Schmitzberger, On the Bromination of Hypericin: The Gymnochrome Chromophores. Monatsh. Chem. 124, 77 (1993)
- C. Etzlstorfer, H. Falk, N. Müller, W. Schmitzberger and U. Wagner, Tautomerism and Stereochemistry of Hypericin: Force Field, NMR, and X-ray Crystallographic Investigations. Monatsh. Chem., 124, 751 (1993)
- H. Falk and A. Suste, On the Chemistry of Pyrrole Pigments, XC: Pyridinologous Linear Tri- and Tetrapyrroles. Monatsh. Chem., 124, 881 (1993)
- H. Falk, J. Meyer and M. Oberreiter, A Convenient Semisynthetic Route to Hypericin. Monatsh. Chem., 124, 339 (1993)
- C. Etzlstorfer and H. Falk, Tautomerism and Stereochemistry of Isohypericin, Bromo-hypericines, and Gymnochromes: Force Field Investigations. Monatsh. Chem., 124, 1031 (1993)
- H. Pschierer, J. Friedrich, H. Falk and W. Schmitzberger, On the Correlation Between Pressure Shift and Solvent Shift: A Spectral Hole Burning Study. J. Phys. Chem., 97, 6902 (1993)
- A. Angerhofer, H. Falk, J. Meyer and G. Schoppel, The Lowest Triplet States of Hypericin and Isohypericin. J. Photochem. Photobiol., B20, 133 (1993)
- H. Falk and A. Suste, On the Chemistry of Pyrrole Pigments, XCI: Copper Complexes of Pyridinologous Linear Tri- and Tetrapyrroles as Cyclopropanation Catalysts. Monatsh. Chem., 125, 325 (1994)
- H. Falk and J. Meyer, On the Homo- and Heteroassociation of Hypericin. Monatsh. Chem., 125, 753 (1994)
- C. Etzlstorfer and H. Falk, Stereochemistry and Tautomerism of Stentorin, Isostentorin, and Fringelit D: Force Field Investigations. Monatsh. Chem., 125, 955 (1994)
- H. Falk, E. Mayr and A. Richter, Simple Diffuse Reflectance UV-Vis Spectroscopic Determination of Organic Pigments (Fringelites) in Fossils. Microchim. Acta, 117, 1 (1994)
- H. Falk and J. Leimhofer, Ozone as an Oxygen Source for Alkene Ene-Reactions. Monatsh. Chem., 126, 85 (1995)
- Q.-Q. Chen, H. Falk and R. Micura, On the Chemistry of Pyrrole Pigments, XCII: Syntheses of 1,2-Bis-pyrrolylethanes. Monatsh. Chem., 126, 473 (1995)
- H. Falk, C. Kratky, N. Müller, W. Schmitzberger and U. Wagner, Structure Determination of the Biliverdin Apomyoglobin Complex. Crystal Structure Analysis of Two Crystal Forms at 1.4 and 1.5 * Resolution. J. Mol. Biol., 247, 326 (1995)
- N. H. Tran-Thi and H. Falk, An Efficient Synthesis of the Plant Growth Hormone 1-Triacontanol. Monatsh. Chem., 126, 565 (1995)
- H. Falk and A. F. Vaisburg, Concerning the Absorption and Emission Properties of Phenanthro [1,10,9,8,o,p,q,r,a]perylene-7,14-dione. Monatsh. Chem., 126, 361 (1995)
- H. Falk and E. Mayr, Syntheses and Properties of Fringelite D (1,3,4,6,8,10,11,13-octahydroxy-phenanthro[1,10,9,8,o,p,q,r,a]perylene-7,14-dione). Monatsh. Chem., 126, 699 (1995)
- H. Falk, A.F. Vaisburg and A.M. Amer, On the Synthesis of w-Appended Hypericin Derivatives. Monatsh. Chem., 126, 993 (1995)
- R. Altmann and H. Falk, On the Syntheses and Chiroptical Properties of the Tri- and Tetragalloylquinic Acids. Monatsh. Chem. 126, 1225 (195)
- D. Shemin and H. Falk, Porphyrins and Bile Pigmens, Metabolism Encyclopedia of Human Biology, 2nd Ed., Academic Press, 177 (1996)
- H. Falk and Q.-Q. Chen, On the Chemistry of Pyrrole Pigments, XCVI: An Efficient Synyhesis of Corrphycenes. Mh. Chem., 127, 69 (1996)
- H. Falk and E. Mayr, Syntheses, Constitutions, and Properties of Stentorin and Isostentorin. Mh. Chem., 126, 1311 (1995)
- H. Falk and T.N.H. Tran, Synthesis and Properties of an w,wÕ - Appended Eighteen Carbon Chains Hypericin Derivative. Mh. Chem., 127, 717 (1996)
- C. Etzlstorfer, H. Falk, N. Müller and T.N.H. Tran, Structural Aspects and Electronic Absorption of the Hydroxyphenanthroperylene Quinones Fringelit D, Hypericin, and Stentorin. Mh. Chem., 127, 659 (1996)
- C. Etzlstorfer, H. Falk, E. Mayr and S. Schwarzinger, Concerning the Acidity and Hydrogen Bonding of Hydroxyphenantroperylene Quinones, like Fringelite D, Hypericin, and Stentorin. Mh. Chem., 127,1229 (1996)
- R. Altmann, C. Etzlstorfer and H. Falk, Chiroptical Properties and Absolute Configurations of the Hypericin Chromophore Propeller Enantiomers. Mh. Chem., 128, 785 (1997)
- H. Falk and M. Stanek, Two-Dimensional 1H and 13C NMR Spectroscopy and the Structural Aspects of Amylose and Amylopectin. Mh. Chem., 128, 777 (1997)
- H. Falk, A.A.O. Sarhan, H.T.N. Tran and R. Altmann, Synthesis and Properties of Hypericins Substituted with Acidic and Basic Residues: Hypericin Tetrasulfonic Acid – a Water Soluble Hypericin Derivative. Mh. Chem., 129, 309 (1998)
- E.I. Kapinuns, H. Falk and T.N.H. Tran, Spectroscopic Investigaion of the Molecular Structures of Hypericin and its Salts. Mh. Chem., 130, 1237 - 1244 (1999)
- A.M. Amer, H. Falk, H.N.T. Tran, The Dissociation and Tautomerization Equilibria of Hypericin: Alkyl Protected Hydroxyl Derivatives. Mh. Chem., 130, 623 - 635 (1999)
- R. Obermüller, G. Schütz, H. Gruber and H. Falk, Concerning Regioselective Photochemical Intermolecular Proton Transfer from Hypericin. Mh. Chem., 130, 275 - 281 (1999)
- G. Kada, H. Falk and H. Gruber, Accurate Measurement of Avidin and Streptavidin in Crude Biofluids with a New, Optimized Biotin. Fluorescein Conjugate. Biochim. Biophys. Acta, 1427, 33 - 43 (1999)
- C. Etzlstorfer, I Gutman and H. Falk, Concerning the Deprotonation ot the Photooxidized 3-Hypericinate Ion. Mh. Chem., 130, 1333 - 1339 (1999)
- T. Dax, H. Falk and E. Kapinus, A Structural Proof for the Hypericin 1,6-Dioxo Tautomer. Mh. Chem., 130, 827 - 831 (1999)
- H. Falk, Gosau Schleifsteine fuer den Fossiliensammler. Fossilien, 4, 248 - 250 (1999)
- H. Falk, Vom Photosensibilisator Hypericin zum Photorezeptor Stentorin - die Chemie der Phenanthroperylenchinone. Angew. Chemie, 111, 3306 - 3326 (1999)
- H. Falk, From the Photosensibilisator Hypericin to the Photoreceptor Stentorin - the Chemistry of the Phenanthroperylene Quinones. Angew. Chemie Int. Ed., 38, 3134 - 3154 (1999)
- S. Baumgartner, T. Dax, W. Praznik and H. Falk, Characterization of the high-molecular weight fructan isolated from garlic (Allium sativum L.). Carbohydrate Res., 328, 177-183 (2000)
- C. Etzlstorfer and H. Falk, Concerning the Association of Hypericin Tautomers and their Hypericinate Ions. Mh. Chem., 131, 333-340 (2000)
- T. Dax, E. Kapinus and H. Falk, A Remarkable Photoreaction of 3-O-Benzylhypericin. Helvetica Chimica Acta, 83, 1744-1752 (2000)
- B. Immitzer, C. Etzlstorfer, R. Obermüller, M. Sonnleitner, G. Schütz, and H. Falk, On the Photochemical Proton Expulsion Capability of Fringelite D — A Model of the Protist Photosensory Pigments of the Stentorin and Blepharismin Types. Mh. Chem., 131, 1039-1045 (2000)
- T. Dax, C. Etzlstorfer, and H. Falk, On the Ground State Energy Hypersurface of Blepharismins and Oxyblepharismins. Mh. Chem., 131, 1115-1122 (2000)
- B. Immitzer and H. Falk, Fringelite D, a Model of the Protist Photosensory Pigments of the Stentorin and Blepharismin Types: the Hypericin and Fringelite D Photosensitized Destruction of Bilirubin. Mh. Chem., 131, 1167-1171 (2000)
- T. Dax and H. Falk, An Unusual Photoreaction of 3,4,-Di-O-benzyl-hypericin. Mh. Chem., 131, 1217-1219 (2000)
- E. Delaey, R. Obermüller, I. Zupko, H. Falk, and P. de Witte, In vitro Study of the Photocytotoxicity of some Hypericin analogs on different Cell Lines. Photochem. Photobiol., 74, 164-171 (2001)
- R.A. Obermüller, K. Hohenthanner, and H. Falk, Towards Hypericin-Derived Potential Photdynamic Therapy Agents. Photochem. Photobiol., 74, 211-215 (2001)
- B. Tu, Q. Chen, F. Yan, J. Ma, K. Grubmayr, and H. Falk, Efficient Routes to w-Chloroalkyl Bilirubins and C12-N22 Bridged Biliverdins. Mh. Chem., 132, 693-705 (2001)
- R.A. Obermüller, T. Dax and H. Falk, Replacement of Methoxy- to tert-Butyl-Substitution on a Napththalene Residue – An Unexpected Reaction Observed During a Snieckus ortho-Lithiation. Mh. Chem., 132, 1057-1062 (2001)
- R.A. Obermüller and H. Falk, Concerning the Absorption and Photochemical Properties of an w-4-Dimethylaminobenzal Hypericin Derivative. Mh. Chem., 132, 1519-1526 (2001)
- R.A. Obermüller, C. Etzlstorfer and H. Falk, On the Chemistry of a Dibenzohypericin Derivative. Mh. Chem., 133, 89-96 (2002)
- J. Leonhartsberger and H. Falk, The Protonation and Deprotonation Equilibria of Hypericin Revisited. Mh. Chem., 133, 167-172 (2002)
- B. Lackner and H. Falk, Concerning the Diastereomerization of Stilbenoid Hypericin Derivatives. Mh. Chem., 133, 717-721 (2002)
- T.N. Tran and H. Falk, Concerning the Chiral Discrimination and Helix Inversion Barrier in Hypericinates and Hypericin Derivatives. Mh. Chem., 133, 1231-1237 (2002)
- M. Emsenhuber, P. Pöchlauer, J.-M. Aubry, V. Nardello and H. Falk, Evidence for the Generation of Singlet Oxygen (1O2, 1Dg) from Ozone Promoted by Inorganic Salts. Mh. Chem., 133, 387-391 (2003)
- M. Deak and H. Falk, On the Chemistry of the Resveratrol Diastereomers. Mh. Chem., 134, 883-888 (2003)
- T.A. Salama, B. Lackner and H. Falk, An Efficient Synthesis of O-Methyl Protected Emodin Aldehyde and Emodin Nitrile. Mh. Chem., 134, 1113-1119 (2003)
- Bettina Schwarzinger, and Heinz Falk, A Unique Photoreaction of Hypericinate Bound to Human Serum Albumin, Lipids, or Vesicles. Mh. Chem., 134, 1353-1358 (2003)
- Beate Hager, Mario Alva-Astudillo, and Heinz Falk, A Hemin-Analogous Corrphycene Derivative: Suppression of Heme Oxygenase and Reconstitution with Apomyoglobin. Mh. Chem., 134, 1499-1507 (2003)
- Tarek A. Salama, Bernd Lackner, and Heinz Falk, Synthesis of 6-Heterocyclically Appendend Tri-O-Methyl Protected 6-Desmethyl Emodin Derivatives. Mh. Chem., 135, 735-742 (2004)
- Thorsten Ganglberger, Walther G. Jary, Peter Pöchlauer, Jean-Marie Aubry, Veronique Nardello, and Heinz Falk, A Chemical (Dark) Source of Singlet Oxygen: Ozone Splitting Promoted by Tin(II) Salts. Mh. Chem., 135, 501-507 (2004)
- Walther G. Jary, Thorsten Ganglberger, Peter Pöchlauer, and Heinz Falk, Generation of Singlet Oxygen from Ozone Catalysed by Phosphinofer-rocenes. Mh. Chem., 136, 537-541 (2005)
- Bernd Lackner, Christoph Etzlstorfer and Heinz Falk, Synthesis and Properties of 10,11-Dibenzimidazolyl-10,11-didesmethyl-hypericin – The First Heterocyclically Substituted Hypericin Derivative. Mh. Chem., 135, 1157-1166 (2004)
- Bettina Schwarzinger and Heinz Falk, Concerning the Photodiastereomerization and Protic Equilibria of Urocanic Acid and its Complex with Human Serum Albumin. Mh. Chem., 135, 1297-1304 (2004)
- Mario Waser, Heinz Falk, Peter Pöchlauer and Walther G. Jary, Concerning Chemistry, Reactivity, and Mechanism of Transition Metal Catalysed Oxidation of Benzylic Compounds by Means of Ozone. Journal of Molecular Catalysis A - Chemical, , 236, 187-193 (2005)
- Mario Waser and Heinz Falk, Intramolecularly Friedel-Crafts Acylated Emodin Derivatives: An Access to the Cores of Angucyclinones, Anthracyclinones, and to Hypericin Analogues. Mh. Chem., 136, 609-618 (2005)
- Bernd Lackner, Yulita Popova, Christiph Etzlstorfer, Andrija A. Smelcerovic, Christian W. Klampfl, and Heinz Falk, Syntheses and Properties of Two Heterocyclically Substituted Hypericin Derivatives: 10,11-Dibenzothiazolyl-10,11-didesmethyl-hypericin and 10,11-Dibenzoxazolyl-10,11-didesmethylhypericin. Mh. Chem., 136, 777-793 (2005)
- Mario Waser, Bernd Lackner, Joachim Zuschrader, Norbert Müller, and Heinz Falk, An efficient regioselective synthesis of endocrocin and structural related natural anthraquinones starting from emodin. Tetrahedron Lett., 46, 2377-2380 (2005)
- Bernd Lackner, Klaus Bretterbauer, and Heinz Falk, An Efficient Route to Emodic Amine and Analogous O-Methyl Protected Derivatives Starting from Emodin. Mh. Chem., 136, 1629-1639 (2005)
- Mario Waser, Yulita Popova, Christoph Etzlstorfer, Werner F. Huber, and Heinz Falk, Syntheses, Photochemical Properties, and Tautomerism of Intramolecularly Friedel-Crafts Acylated Hypericin Derivatives. Mh. Chem., 136, 1221-1231 (2005)
- David Geißlmeir, Walther G. Jary and Heinz Falk, The TEMPO/Copper Catalyzed Oxidation of Primary Alcohols to Aldehydes Using Oxygen as Stoichometric Oxidant. Mh. Chem., 136, 1591-1599 (2005)
- Mario Waser, Yulita Popova, Christian W. Klampfl, and Heinz Falk, 9,12-Dibenzothiazolylhypericin and 10,11-Dibenzothiazolyl-10,11-Didemethylhypericin: Photochemical Properties of Hypericin Derivatives Depending on the Substitution Site. Mh.Chem., 136, 1791-1797 (2005)
- Klaus Wolkenstein, Jürgen H. Gross, Heinz Falk, and Heinz F. Schöler, Preservation of hypericin and related polycyclic quinone pigments in fossil crinoids. Proceedings of the Royal Society B, 273, 451-456 (2006)
- Beate Hager, Bettina Schwarzinger and Heinz Falk, Concerning the Thermal Diastereomerization of the Green Fluorescent Protein Chromophore. Mh. Chem., 137, 163-168 (2006)
- Mario Waser and Heinz Falk, Condensed Emodin Derivatives and Their Applicability for the Synthesis of a Fused Heterocyclic Hypericin Derivative. Eur. J. Org. Chem., 1200-1206 (2006)
- Mario Waser and Heinz Falk, Towards Second Generation Hypericin Based Photosensitizers for Photodynamic Therapy. Curr. Org. Chem. 11: 547-558 (2007)
- Heinz Falk: Karl Schlögl. Obituary. Mh. Chem., 138 (2007)
- Karoline Fendler, Beate Hager, and Heinz Falk, The Thermal Diastereomerization of the Tryptophane-Derived Green Fluorescent Protein Chromophore. Mh. Chem., 138, 859-862 (2007)
- Mieke Roelants, Heinz Falk, Bernd Lackner, Mario Waser, Peter A.M. de Witte, OC222 Bathochromically shifted hypericin derivatives: photosensitizing properties. Abstr. of 12th Congress of the Europaean Society for Photobiology 2007, University of Bath, UK, Sept 1/6, (2007)
- Heinz Falk, Die 44. Mineralientage München - ein Rückblick. Fossilien, 25, 2-4 (2008)
- Heinz Falk. Karl Schlögl, Nachruf. Almanach d. Öst. Akademie der Wiss. , 157, 469-477 (2008)
Patents
- Process for the N-alkylation or ureas US Pat. 5124451 - Filed Jul 10, 1991 - Chemie Linz GmbH
- Process for the N-alkylation of ureas US Pat. 5169954 - Filed Dec 16, 1991 - Chemie Linz GmbH
- Process for the preparation of pure N,N'-asymmetrically substituted phenylureas US Pat. 5283362 - Filed Jul 31, 1992 - Chemie Linz GmbH
- Process for the preparation of Isocyanic Acid by Decomposition of N,N-trisubstituted Ureas Eur. Pat. EP 0582863A2 - Filed Feb 16, 1994 - US Pat. Nr. 5360601 Filed Nov 1, 1994 - Chemie Linz GmbH
- Isocyanates by Decomposition of N,N,N-trisubstituted Ureas Eur. Pat. EP 0583637A1 - Filed Feb 23, 1994 - Chemie Linz GmbH
- Amine-oxides US Pat. 5409532 - Filed Jan 21, 1993 - Lenzing AG
Awards
- Theodor KörnerTheodor Körner----Theodor Körner, Edler von Siegringen served as the fifth President of Austria, between 1951 and 1957.- Life :...
Prize for Science and Art in Austria, 1970 - Ernst SpäthErnst SpäthErnst Späth was an Austrian chemist.He was the first to synthesise Mescaline and was one of the first to synthesize cuscohygrine on a small scale with Hans Tuppy....
Prize of the Austrian Academy of SciencesAustrian Academy of SciencesThe Austrian Academy of Sciences is a legal entity under the special protection of the Federal Republic of Austria. According to the statutes of the Academy its mission is to promote the sciences and humanities in every respect and in every field, particularly in fundamental research...
, 1976 - SandozSandozFounded in 2003, Sandoz presently is the generic drug subsidiary of Novartis, a multinational pharmaceutical company. The company develops, manufactures and markets generic drugs as well as pharmaceutical and biotechnological active ingredients....
Prize, 1977 - Election to corresponding member of the New York Academy of SciencesNew York Academy of SciencesThe New York Academy of Sciences is the third oldest scientific society in the United States. An independent, non-profit organization with more than members in 140 countries, the Academy’s mission is to advance understanding of science and technology...
, 1989 - Election to corresponding member of the Mathematical and Natural Sciences Class of the Austrian Academy of SciencesAustrian Academy of SciencesThe Austrian Academy of Sciences is a legal entity under the special protection of the Federal Republic of Austria. According to the statutes of the Academy its mission is to promote the sciences and humanities in every respect and in every field, particularly in fundamental research...
, 1992 - Upper Austrian Prize for Science, 1993
- Election to full member of the Mathematical and Natural Sciences Class of the Austrian Academy of SciencesAustrian Academy of SciencesThe Austrian Academy of Sciences is a legal entity under the special protection of the Federal Republic of Austria. According to the statutes of the Academy its mission is to promote the sciences and humanities in every respect and in every field, particularly in fundamental research...
, 1997 - Josef Loschmidt Medal of the Austrian Chemical Society, 1998
- Election as member of the European Academy of SciencesEuropean Academy of SciencesThe European Academy of Sciences has as mission to promote excellence in science and technology and their essential roles in fostering social and economic development and progress. It is registered in and operates under rules and regulations of Belgium. The European Academy of Sciences is an...
, 2003 - Scientific award of the Rudolf Trauner Stiftung, 2003
- Silver medal of the government of Upper AustriaUpper AustriaUpper Austria is one of the nine states or Bundesländer of Austria. Its capital is Linz. Upper Austria borders on Germany and the Czech Republic, as well as on the other Austrian states of Lower Austria, Styria, and Salzburg...
, 2009
See also
- HypericinHypericinHypericin is a naphthodianthrone, a red-colored anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum . Hypericin is believed to act as an antibiotic and non-specific kinase inhibitor...
- Organic chemistryOrganic chemistryOrganic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions, and preparation of carbon-based compounds, hydrocarbons, and their derivatives...
- Physical organic chemistryPhysical organic chemistryPhysical organic chemistry is the study of the interrelationships between structure and reactivity in organic molecules. It can be seen as the study of organic chemistry using tools of physical chemistry such as chemical equilibrium, chemical kinetics, thermochemistry, and quantum chemistry...
- Johannes Kepler University of LinzJohannes Kepler University of LinzThe Johannes Kepler University of Linz is a public institution of higher education in Linz, the capital of Upper Austria...
- University of ViennaUniversity of ViennaThe University of Vienna is a public university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world...