Heinrich Quincke
Encyclopedia
Heinrich Irenaeus Quincke (26 August 1842 - 19 May 1922) was a German internist
Internal medicine
Internal medicine is the medical specialty dealing with the prevention, diagnosis, and treatment of adult diseases. Physicians specializing in internal medicine are called internists. They are especially skilled in the management of patients who have undifferentiated or multi-system disease processes...

 and surgeon
Surgeon
In medicine, a surgeon is a specialist in surgery. Surgery is a broad category of invasive medical treatment that involves the cutting of a body, whether human or animal, for a specific reason such as the removal of diseased tissue or to repair a tear or breakage...

. His main contribution to internal medicine was the introduction of the lumbar puncture
Lumbar puncture
A lumbar puncture is a diagnostic and at times therapeutic procedure that is performed in order to collect a sample of cerebrospinal fluid for biochemical, microbiological, and cytological analysis, or very rarely as a treatment to relieve increased intracranial pressure.-Indications:The...

 for diagnostic and therapeutic purposes. After 1874, his main area of research was pulmonary medicine.

Biography

Born at Frankfurt an der Oder, Heinrich was the son of prominent physician Hermann Quincke and the younger brother of physicist Georg Hermann Quincke
Georg Hermann Quincke
Georg Quincke|thumbGeorg Hermann Quincke was a German physicist.Born at Frankfurt , Quincke was the son of prominent physician Geheimer Medicinal-Rath Hermann Quincke and the older brother of physician Heinrich Quincke.Quincke received his Ph. D. in 1858 at Berlin, having previously studied also...

. He received his doctorate in 1863 from the University of Berlin, having studied previously at the University of Heidelberg and at the University of Würzburg
University of Würzburg
The University of Würzburg is a university in Würzburg, Germany, founded in 1402. The university is a member of the distinguished Coimbra Group.-Name:...

 under Rudolf Virchow
Rudolf Virchow
Rudolph Carl Virchow was a German doctor, anthropologist, pathologist, prehistorian, biologist and politician, known for his advancement of public health...

 and Albert von Kölliker
Albert von Kölliker
Albert von Kölliker was a Swiss anatomist and physiologist.-Biography:Albert Kölliker was born in Zurich, Switzerland. His early education was carried on in Zurich, and he entered the university there in 1836...

.

In 1865, Quincke worked with physiologist Ernst Wilhelm von Brücke
Ernst Wilhelm von Brücke
Ernst Wilhelm Ritter von Brücke was a German physician and physiologist.He was born Ernst Wilhelm Brücke in Berlin. He graduated in medicine at University of Berlin in 1842, the following year he became esearch assistant to Johannes Peter Müller...

 at the University of Vienna
University of Vienna
The University of Vienna is a public university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world...

, and in 1866, he became the assistant to the surgeon Robert Ferdinand Wilms
Robert Ferdinand Wilms
Robert Friedrich Wilms was a German surgeon who was a native of Arnswalde. He studied medicine in Berlin, and in 1848 became an assistant at the Bethanien Hospital in Berlin...

. He was an "assistenzarzt" (subordinate physician) in internal medicine under Friedrich Theodor von Frerichs
Friedrich Theodor von Frerichs
Friedrich Theodor von Frerichs was a German pathologist who was born in Aurich. After earning his medical degree from the University of Göttingen in 1841, he returned to Aurich and spent the next four years there as an optician...

 at the Charité
Charité
The Charité - Universitätsmedizin Berlin is the medical school for both the Humboldt University and the Free University of Berlin. After the merger with their fourth campus in 2003, the Charité is one of the largest university hospitals in Europe....

 in Berlin
Berlin
Berlin is the capital city of Germany and is one of the 16 states of Germany. With a population of 3.45 million people, Berlin is Germany's largest city. It is the second most populous city proper and the seventh most populous urban area in the European Union...

 until 1870.

In 1873, Quincke became a professor of internal medicine at the University of Berne
University of Berne
The University of Bern is a university in the Swiss capital of Bern and was founded in 1834. It is regulated and financed by the Canton of Bern. It is a comprehensive university offering a broad choice of courses and programmes in eight faculties and some 160 institutes. The university is an...

. Five years later, he moved to the University of Kiel
University of Kiel
The University of Kiel is a university in the city of Kiel, Germany. It was founded in 1665 as the Academia Holsatorum Chiloniensis by Christian Albert, Duke of Holstein-Gottorp and has approximately 23,000 students today...

 and became a professor emeritus in 1908. He died in Frankfurt am Main
Frankfurt
Frankfurt am Main , commonly known simply as Frankfurt, is the largest city in the German state of Hesse and the fifth-largest city in Germany, with a 2010 population of 688,249. The urban area had an estimated population of 2,300,000 in 2010...

, where he had been giving lectures until his death.

Discoveries

He was perhaps the first (1882) to recognize angioedema
Angioedema
Angioedema or Quincke's edema is the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues. It is very similar to urticaria, but urticaria, commonly known as hives, occurs in the upper dermis...

 which is often referred to as "Quincke's edema". "Quincke's pulse", with redness and pallor seen under the fingernails, is one of the signs of aortic insufficiency
Aortic insufficiency
Aortic insufficiency , also known as aortic regurgitation , is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle....

. "Quincke's puncture" is a somewhat outdated eponym for lumbar puncture
Lumbar puncture
A lumbar puncture is a diagnostic and at times therapeutic procedure that is performed in order to collect a sample of cerebrospinal fluid for biochemical, microbiological, and cytological analysis, or very rarely as a treatment to relieve increased intracranial pressure.-Indications:The...

, used for the examination of the cerebrospinal fluid
Cerebrospinal fluid
Cerebrospinal fluid , Liquor cerebrospinalis, is a clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord...

 in numerous diseases such as meningitis
Meningitis
Meningitis is inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation may be caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs...

 and multiple sclerosis
Multiple sclerosis
Multiple sclerosis is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms...

. In 1893 he described what is now known as idiopathic intracranial hypertension
Idiopathic intracranial hypertension
Idiopathic intracranial hypertension , sometimes called by the older names benign intracranial hypertension or pseudotumor cerebri , is a neurological disorder that is characterized by increased intracranial pressure in the absence of a tumor or other diseases...

, which he labeled "serous meningitis".

External links

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