Geranylgeraniol
Encyclopedia
Geranylgeraniol is a diterpene
alcohol
which plays a role a several important biological processes. It is an intermediate in the biosynthesis
of other diterpenes and of vitamins E
and K
. It also used in the post-translational modification known as geranylgeranylation
. Geranylgeraniol is a pheromone for bumblebee
s and a variety of other insects.
Geranylgeraniol is a potent inhibitor of Mycobacterium tuberculosis in vitro
.
Diterpene
Diterpenes are a type of terpenes composed of four isoprene units. They derive from geranylgeranyl pyrophosphate. Diterpenes form the basis for biologically important compounds such as retinol, retinal, and phytol...
alcohol
Alcohol
In chemistry, an alcohol is an organic compound in which the hydroxy functional group is bound to a carbon atom. In particular, this carbon center should be saturated, having single bonds to three other atoms....
which plays a role a several important biological processes. It is an intermediate in the biosynthesis
Biosynthesis
Biosynthesis is an enzyme-catalyzed process in cells of living organisms by which substrates are converted to more complex products. The biosynthesis process often consists of several enzymatic steps in which the product of one step is used as substrate in the following step...
of other diterpenes and of vitamins E
Vitamin E
Vitamin E is used to refer to a group of fat-soluble compounds that include both tocopherols and tocotrienols. There are many different forms of vitamin E, of which γ-tocopherol is the most common in the North American diet. γ-Tocopherol can be found in corn oil, soybean oil, margarine and dressings...
and K
Vitamin K
Vitamin K is a group of structurally similar, fat soluble vitamins that are needed for the posttranslational modification of certain proteins required for blood coagulation and in metabolic pathways in bone and other tissue. They are 2-methyl-1,4-naphthoquinone derivatives...
. It also used in the post-translational modification known as geranylgeranylation
Geranylgeranylation
Geranylgeranylation is a form of prenylation, which is a post-translational modification of proteins that involves the attachment of one or two 20-carbon lipophilic geranylgeranyl isoprene units from geranylgeranyl diphosphate to one or two cysteine residue at the C-terminus of specific proteins...
. Geranylgeraniol is a pheromone for bumblebee
Bumblebee
A bumble bee is any member of the bee genus Bombus, in the family Apidae. There are over 250 known species, existing primarily in the Northern Hemisphere although they are common in New Zealand and in the Australian state of Tasmania.Bumble bees are social insects that are characterised by black...
s and a variety of other insects.
Geranylgeraniol is a potent inhibitor of Mycobacterium tuberculosis in vitro
In vitro
In vitro refers to studies in experimental biology that are conducted using components of an organism that have been isolated from their usual biological context in order to permit a more detailed or more convenient analysis than can be done with whole organisms. Colloquially, these experiments...
.