Gaston Ramon
Encyclopedia
Gaston Ramon was a French
France
The French Republic , The French Republic , The French Republic , (commonly known as France , is a unitary semi-presidential republic in Western Europe with several overseas territories and islands located on other continents and in the Indian, Pacific, and Atlantic oceans. Metropolitan France...

 veterinarian
Veterinarian
A veterinary physician, colloquially called a vet, shortened from veterinarian or veterinary surgeon , is a professional who treats disease, disorder and injury in animals....

 and biologist
Biologist
A biologist is a scientist devoted to and producing results in biology through the study of life. Typically biologists study organisms and their relationship to their environment. Biologists involved in basic research attempt to discover underlying mechanisms that govern how organisms work...

 best known for his role in the treatment of diphtheria
Diphtheria
Diphtheria is an upper respiratory tract illness caused by Corynebacterium diphtheriae, a facultative anaerobic, Gram-positive bacterium. It is characterized by sore throat, low fever, and an adherent membrane on the tonsils, pharynx, and/or nasal cavity...

 and tetanus
Tetanus
Tetanus is a medical condition characterized by a prolonged contraction of skeletal muscle fibers. The primary symptoms are caused by tetanospasmin, a neurotoxin produced by the Gram-positive, rod-shaped, obligate anaerobic bacterium Clostridium tetani...

.

He was born in Bellechaume
Bellechaume
Bellechaume is a commune in the Yonne department in Burgundy in north-central France....

 (Yonne
Yonne
Yonne is a French department named after the Yonne River. It is one of the four constituent departments of Burgundy in eastern France and its prefecture is Auxerre. Its official number is 89....

, France
France
The French Republic , The French Republic , The French Republic , (commonly known as France , is a unitary semi-presidential republic in Western Europe with several overseas territories and islands located on other continents and in the Indian, Pacific, and Atlantic oceans. Metropolitan France...

) and attended l'École vétérinaire d'Alfort from 1906 to 1910. In 1917 he married Marthe Momont, grandniece of Emile Roux.

During the 1920s, Ramon made major contributions to the development of effective vaccines for both diphtheria
Diphtheria
Diphtheria is an upper respiratory tract illness caused by Corynebacterium diphtheriae, a facultative anaerobic, Gram-positive bacterium. It is characterized by sore throat, low fever, and an adherent membrane on the tonsils, pharynx, and/or nasal cavity...

 and tetanus
Tetanus
Tetanus is a medical condition characterized by a prolonged contraction of skeletal muscle fibers. The primary symptoms are caused by tetanospasmin, a neurotoxin produced by the Gram-positive, rod-shaped, obligate anaerobic bacterium Clostridium tetani...

. In particular, he developed a method for inactivating the diphtheria toxin
Toxin
A toxin is a poisonous substance produced within living cells or organisms; man-made substances created by artificial processes are thus excluded...

 and the tetanus toxin using formaldehyde
Formaldehyde
Formaldehyde is an organic compound with the formula CH2O. It is the simplest aldehyde, hence its systematic name methanal.Formaldehyde is a colorless gas with a characteristic pungent odor. It is an important precursor to many other chemical compounds, especially for polymers...

which, in its essentials, is still used in vaccines manufactured today. He also developed a method for determining the potency of the vaccines, an essential element required for the reproducible production of these pharmaceuticals.

Reference:

Ebisawa, I. 1987. The encounter of Gaston Ramon (1886-1963) with formalin: A biographical study of a great scientist. Kitasato Archives of Experimental Medicine 60 (3): 55-70.
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