G-130
Encyclopedia
G-130 is a drug with stimulant
and anorectic
effects, related to phenmetrazine
.
were synthesized that behave as combined inhibitors of monoamine uptake
and nAChRs.
Stimulant
Stimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others...
and anorectic
Anorectic
An anorectic or anorexic , also known as anorexigenic or appetite suppressant, is a dietary supplement and/or drug which reduces appetite, food consumption, and as a result, causes weight loss to occur.-List of anorectics:Numerous pharmaceutical compounds are marketed as appetite suppressants.The...
effects, related to phenmetrazine
Phenmetrazine
Phenmetrazine is a stimulant drug of the morpholine chemical class that was previously used as an appetite suppressant, but has since been withdrawn from the market...
.
Structural analogs
Compounds related to G 130 and radafaxineRadafaxine
Radafaxine is drug candidate designated GW-353,162 by GlaxoSmithKline, investigated for treatment of restless leg syndrome and as an NDRI antidepressant...
were synthesized that behave as combined inhibitors of monoamine uptake
Reuptake inhibitor
A reuptake inhibitor , also known as a transporter blocker, is a drug that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an...
and nAChRs.
See also
- 2-Phenyl-3,6-dimethylmorpholine2-Phenyl-3,6-dimethylmorpholine2-Phenyl-3,6-dimethylmorpholine is a drug with stimulant and anorectic effects, related to phenmetrazine.-See also:* G-130 * Phendimetrazine * Manifaxine* Radafaxine...
- PhendimetrazinePhendimetrazinePhendimetrazine is a stimulant drug of the morpholine chemical class used as an appetite suppressant....
(2-Phenyl-3,4-dimethylmorpholine) - ManifaxineManifaxineManifaxine is a drug developed by GlaxoSmithKline through structural modification of radafaxine, the active metabolite of bupropion. It acts as a norepinephrine-dopamine reuptake inhibitor...
- RadafaxineRadafaxineRadafaxine is drug candidate designated GW-353,162 by GlaxoSmithKline, investigated for treatment of restless leg syndrome and as an NDRI antidepressant...