Fusion transcript
Encyclopedia
Fusion transcript is a chimeric RNA
encoded by a fusion gene
or by two different genes by subsequent trans-splicing
. Certain fusion transcripts are commonly produced by cancer
cells, and detection of fusion transcripts is part of routine diagnostics of certain cancer types.
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
encoded by a fusion gene
Fusion gene
A fusion gene is a hybrid gene formed from two previously separate genes. It can occur as the result of a translocation, interstitial deletion, or chromosomal inversion...
or by two different genes by subsequent trans-splicing
Trans-splicing
Trans-splicing is a special form of RNA processing in eukaryotes where exons from two different primary RNA transcripts are joined end to end and ligated....
. Certain fusion transcripts are commonly produced by cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
cells, and detection of fusion transcripts is part of routine diagnostics of certain cancer types.