Franc Gubenšek
Encyclopedia
Franc Gubenšek was a Slovene biochemist
and academic, notable for his work on toxin
s in snake venom
. Gubenšek's research focused on neurotoxic
phospholipase
s. With his colleagues at the Jožef Stefan Institute
, he was one of the first Slovene scientists to determine primary structure of those proteins, later focusing on their receptors
and developing a hypothesis
about the mechanism of their activity. In later years, he studied molecular evolution
of snake venom toxins. He co-discovered a novel mobile element
of DNA and demonstrated horizontal gene transfer
of this element between snakes and ruminants
in evolutionary history which attracted significant attention of the scientific community.
Apart from his scientific work, Gubenšek chaired the biochemistry department at the Faculty of Chemistry and Chemical Technology (University of Ljubljana
), organized several scientific conferences and served in the editorial boards of the journals Acta Chimica Slovenica and Toxicon
. He was elected as a member of the European Molecular Biology Organization
as the first scientist from Slovenia, and a member of the Slovenian Academy of Sciences and Arts
.
Biochemist
Biochemists are scientists who are trained in biochemistry. Typical biochemists study chemical processes and chemical transformations in living organisms. The prefix of "bio" in "biochemist" can be understood as a fusion of "biological chemist."-Role:...
and academic, notable for his work on toxin
Toxin
A toxin is a poisonous substance produced within living cells or organisms; man-made substances created by artificial processes are thus excluded...
s in snake venom
Snake venom
Snake venom is highly modified saliva that is produced by special glands of certain species of snakes. The glands which secrete the zootoxin are a modification of the parotid salivary gland of other vertebrates, and are usually situated on each side of the head below and behind the eye,...
. Gubenšek's research focused on neurotoxic
Neurotoxicity
Neurotoxicity occurs when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system in such a way as to cause damage to nervous tissue. This can eventually disrupt or even kill neurons, key cells that transmit and process...
phospholipase
Phospholipase
A phospholipase is an enzyme that hydrolyzes phospholipids into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, distinguished by the type of reaction which they catalyze:*Phospholipase A...
s. With his colleagues at the Jožef Stefan Institute
Jožef Stefan Institute
The Jožef Stefan Institute , is the largest research institute in Slovenia. The main research areas are physics, chemistry, molecular biology, biotechnology, information technologies, reactor physics, energy and environment...
, he was one of the first Slovene scientists to determine primary structure of those proteins, later focusing on their receptors
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
and developing a hypothesis
Hypothesis
A hypothesis is a proposed explanation for a phenomenon. The term derives from the Greek, ὑποτιθέναι – hypotithenai meaning "to put under" or "to suppose". For a hypothesis to be put forward as a scientific hypothesis, the scientific method requires that one can test it...
about the mechanism of their activity. In later years, he studied molecular evolution
Molecular evolution
Molecular evolution is in part a process of evolution at the scale of DNA, RNA, and proteins. Molecular evolution emerged as a scientific field in the 1960s as researchers from molecular biology, evolutionary biology and population genetics sought to understand recent discoveries on the structure...
of snake venom toxins. He co-discovered a novel mobile element
Transposon
Transposable elements are sequences of DNA that can move or transpose themselves to new positions within the genome of a single cell. The mechanism of transposition can be either "copy and paste" or "cut and paste". Transposition can create phenotypically significant mutations and alter the cell's...
of DNA and demonstrated horizontal gene transfer
Horizontal gene transfer
Horizontal gene transfer , also lateral gene transfer , is any process in which an organism incorporates genetic material from another organism without being the offspring of that organism...
of this element between snakes and ruminants
Ruminantia
Ruminantia includes many of the well-known large grazing or browsing mammals: among them cattle, goats, sheep, deer, and antelope. All members of the Ruminantia are ruminants: they digest food in two steps, chewing and swallowing in the normal way to begin with, and then regurgitating the...
in evolutionary history which attracted significant attention of the scientific community.
Apart from his scientific work, Gubenšek chaired the biochemistry department at the Faculty of Chemistry and Chemical Technology (University of Ljubljana
University of Ljubljana
The University of Ljubljana is the oldest and largest university in Slovenia. With 64,000 enrolled graduate and postgraduate students, it is among the largest universities in Europe.-Beginnings:...
), organized several scientific conferences and served in the editorial boards of the journals Acta Chimica Slovenica and Toxicon
Toxicon
Toxicon is a peer-reviewed scientific journal of toxinology, and the official journal of the International Society on Toxinology. It is published by Elsevier and is edited by Alan L. Harvey...
. He was elected as a member of the European Molecular Biology Organization
European Molecular Biology Organization
EMBO stands for excellence in the life sciences. The EMBO mission is to enable the best science by supporting talented researchers, stimulating scientific exchange and advancing policies for a world-class European research environment....
as the first scientist from Slovenia, and a member of the Slovenian Academy of Sciences and Arts
Slovenian Academy of Sciences and Arts
The Slovenian Academy of Sciences and Arts is the national academy of Slovenia, which encompasses science and the arts and brings together the top Slovene researchers and artists as members of the academy....
.