Fibronectin type III domain - AbsoluteAstronomy.com

The Fibronectin type III domain is an evolutionary conserved protein domain

Protein domain

A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...

that is widely found in animal proteins. The fibronectin

Fibronectin

Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin and heparan sulfate proteoglycans...

protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100 amino acid

Amino acid

Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...

s long and possesses a beta sandwich structure. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found more sporadically in yeast, plant and bacterial proteins.

Human proteins containing this domain

ABI3BP; ANKFN1; ASTN2; AXL

AXL receptor tyrosine kinase

Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene.-Interactions:AXL receptor tyrosine kinase has been shown to interact with TENC1.-Further reading:...

; BOC

BOC (gene)

Brother of CDO is a protein that in humans is encoded by the BOC gene.-Interactions:BOC has been shown to interact with CDON.-Further reading:...

; BZRAP1; C20orf75; CDON

CDON

Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.-Interactions:CDON has been shown to interact with CDH1 and BOC.-Further reading:...

;
CHL1

CHL1

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 is a protein that in humans is encoded by the CHL1 gene.CHL1 is a cell adhesion molecule closely related to the L1...

; CMYA5; CNTFR; CNTN1

CNTN1

Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene.- Function :The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol -anchored neuronal membrane protein that functions as a cell adhesion molecule...

; CNTN2

CNTN2

Contactin-2 is a protein that in humans is encoded by the CNTN2 gene.-Interactions:CNTN2 has been shown to interact with CNTNAP2 and NFYB.-Further reading:...

; CNTN3

CNTN3

Contactin-3 is a protein that in humans is encoded by the CNTN3 gene.-Further reading:...

; CNTN4

CNTN4

Contactin-4 is a protein that in humans is encoded by the CNTN4 gene.-Genomics:The gene is located on the short arm of chromosome 3...

; CNTN5;
CNTN6; COL12A1

COL12A1

Collagen alpha-1 chain is a protein that in humans is encoded by the COL12A1 gene.-Further reading:...

; COL14A1

COL14A1

Collagen alpha-1 chain is a protein that in humans is encoded by the COL14A1 gene.-Further reading:...

; COL20A1

COL20A1

COL20A1 is a collagen gene....

; COL7A1

COL7A1

Collagen alpha-1 chain is a protein that in humans is encoded by the COL7A1 gene.- Function :This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous...

; CRLF1

CRLF1

Cytokine receptor-like factor 1 is a protein that in humans is encoded by the CRLF1 gene.- Function :This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic...

; CRLF3

CRLF3

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene....

; CSF2RB

CSF2RB

CSF2RB is a common subunit to the following type I cytokine receptors:*GM-CSF receptor*IL-3 receptor*IL-5 receptor.-External links:...

;
CSF3R; DCC

Deleted in Colorectal Cancer

Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer. While the official, full name of this gene is Deleted in Colorectal Carcinoma, it is almost universally called Deleted in Colorectal Cancer...

; DSCAM

DSCAM

DSCAM and Dscam are both abbreviations for Down Syndrome Cell Adhesion Molecule. The case difference is significant: DSCAM refers to the human protein, and Dscam refers to its analog in Drosophila....

; DSCAML1; EBI3

EBI3

Epstein-Barr virus induced gene 3, also known as EBI3, is a protein which in humans is encoded by the EBI3 gene.- Function :This gene was identified by the induction of its expression in B lymphocytes by Epstein-Barr virus infection...

; EGFLAM; EPHA1

EPHA1

EPH receptor A1 is a protein that in humans is encoded by the EPHA1 gene.-Further reading:...

; EPHA10;
EPHA2; EPHA3

EPHA3

EPH receptor A3 is a protein that in humans is encoded by the EPHA3 gene.-Interactions:EPH receptor A3 has been shown to interact with EFNB2 and EFNA5.-Further reading:...

; EPHA4; EPHA5

EPHA5

EPH receptor A5 is a protein that in humans is encoded by the EPHA5 gene.-Further reading:...

; EPHA6

EPHA6

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.-Further reading:...

; EPHA7

EPHA7

Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene.-Further reading:...

; EPHA8

EPHA8

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.-Further reading:...

; EPHB1;
EPHB2; EPHB3

EPHB3

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.-Interactions:EPHB3 has been shown to interact with MLLT4 and RAS p21 protein activator 1.-Further reading:...

; EPHB4; EPHB6

EPHB6

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.-Further reading:...

; EPOR

Erythropoietin receptor

The erythropoietin receptor is a protein that in humans is encoded by the EPOR gene. EpoR is a 59 kDa peptide and is a member of the cytokine receptor family. EpoR pre-exists as dimers...

; FANK1; FLRT1; FLRT2

FLRT2

Leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.-Further reading:...

;
FLRT3

FLRT3

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.-Further reading:...

; FN1; FNDC1; FNDC3A

FNDC3A

Fibronectin type-III domain-containing protein 3a is a protein that in humans is encoded by the FNDC3A gene.-Further reading:...

; FNDC3B; FNDC4; FNDC5; FNDC7;
FNDC8; FSD1; FSD1L; FSD2; GHR

Growth hormone receptor

Growth hormone receptor is a protein that in humans is encoded by the GHR gene. GHR orthologs have been identified in most mammals.-Interactions:...

; HCFC1; HCFC2; HUGO;
IFNGR2; IGF1R; IGSF22; IGSF9; IGSF9B; IL11RA; IL12B; IL12RB1;
IL12RB2; IL20RB; IL23R; IL27RA; IL31RA

IL31RA

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.-Further reading:...

; IL6R; IL6ST; IL7R;
INSR; INSRR

INSRR

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.-Further reading:...

; ITGB4

ITGB4

Integrin, beta 4 also known as CD104 , is a human gene.-Interactions:ITGB4 has been shown to interact with Collagen, type XVII, alpha 1, EIF6 and Erbin.-Further reading:...

; Il6ST; KAL1; KALRN; L1CAM; LEPR;
LIFR; LRFN2; LRFN3; LRFN4; LRFN5; LRIT1; LRRN1

LRRN1

Leucine-rich repeat neuronal protein 1 is a protein that in humans is encoded by the LRRN1 gene.-Further reading:...

; LRRN3

LRRN3

Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 , is a protein that in humans is encoded by the LRRN3 gene.-Gene:...

;
MERTK

MERTK

Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.-External links:*...

; MID1

MID1

Midline-1 is a protein that in humans is encoded by the MID1 gene.-External links:...

; MID2

MID2

Midline-2 is a protein that in humans is encoded by the MID2 gene.-Further reading:...

; MPL

Myeloproliferative leukemia virus oncogene

Myeloproliferative leukemia virus oncogene also known as CD110 , is a human gene.-Interactions:Myeloproliferative leukemia virus oncogene has been shown to interact with ATXN2L....

; MYBPC1

MYBPC1

Myosin-binding protein C, slow-type is a protein that in humans is encoded by the MYBPC1 gene.-Further reading:...

; MYBPC2; MYBPC3; MYBPH;
MYBPHL; MYLK

MYLK

Myosin light chain kinase, smooth muscle also known as kinase-related protein or telokin is an enzyme that in humans is encoded by the MYLK gene.- Function :...

; MYOM1

MYOM1

Myomesin-1 is a protein that in humans is encoded by the MYOM1 gene.-Further reading:...

; MYOM2

MYOM2

Myomesin-2 is a protein that in humans is encoded by the MYOM2 gene.-Further reading:...

; MYOM3; NCAM1; NCAM2; NEO1

NEO1

Neogenin is a protein that in humans is encoded by the NEO1 gene.-Further reading:...

;
NFASC

NFASC

Neurofascin is a protein that in humans is encoded by the NFASC gene.- Function :Neurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development....

; NOPE; NPHS1; NRCAM

NRCAM

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.-Further reading:...

; OBSCN

OBSCN

Obscurin is a protein that in humans is encoded by the OBSCN gene.-Interactions:OBSCN has been shown to interact with Titin and ANK1.-Further reading:...

; OBSL1

OBSL1

Obscurin-like protein 1 is a protein that in humans is encoded by the OBSL1 gene.-External Links:* *...

; OSMR; PHYHIP;
PHYHIPL

PHYHIPL

Phytanoyl-CoA hydroxylase-interacting protein-like is an enzyme that in humans is encoded by the PHYHIPL gene.-Further reading:...

; PRLR

Prolactin receptor

The prolactin receptor—encoded by a gene on Chromosome 5p13-14—interacts with the prolactin molecule as a transmembrane receptor.Thus it contains an extracellular region that binds prolactin, a transmembrane regions, and a cytoplasmatic region....

; PRODH2; PTPRB

PTPRB

Receptor-type tyrosine-protein phosphatase beta is an enzyme that in humans is encoded by the PTPRB gene.-Interactions:PTPRB has been shown to interact with CNTN1, MAGI3 and VE-cadherin.-Further reading:...

; PTPRC; PTPRD

PTPRD

Receptor-type tyrosine-protein phosphatase delta is an enzyme that in humans is encoded by the PTPRD gene.- Function :The protein encoded by this gene is a member of the protein tyrosine phosphatase family...

; PTPRF

PTPRF

Receptor-type tyrosine-protein phosphatase F is an enzyme that in humans is encoded by the PTPRF gene.The protein encoded by this gene is a member of the protein tyrosine phosphatase family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell...

; PTPRG

PTPRG

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.-Further reading:...

;
PTPRH

PTPRH

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.-Further reading:...

; PTPRJ

PTPRJ

Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.-Further reading:...

; PTPRK

PTPRK

Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the PTPRK gene.-Interactions:PTPRK has been shown to interact with Beta-catenin and Plakoglobin.-Further reading:...

; PTPRM

PTPRM

Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene.- Function :The protein encoded by this gene is a member of the protein tyrosine phosphatase family. Protein tyrosine phosphatases are protein enzymes that remove phosphate moieties from tyrosine...

; PTPRO

PTPRO

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.-Further reading:...

; PTPRS

PTPRS

Receptor-type tyrosine-protein phosphatase S is an enzyme that in humans is encoded by the PTPRS gene.-Interactions:PTPRS has been shown to interact with PTPRD and [liprin-alpha-1]].-Further reading:...

; PTPRT

PTPRT

Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene.PTPRT is also known as human accelerated region 9. It may, therefore, have played a key role in differentiating humans from apes.-Further reading:...

; PTPRU

PTPRU

Receptor-type tyrosine-protein phosphatase U is an enzyme that in humans is encoded by the PTPRU gene.-Further reading:...

;
PTPRZ1

PTPRZ1

Receptor-type tyrosine-protein phosphatase zeta is an enzyme that in humans is encoded by the PTPRZ1 gene.-Further reading:...

; PTPsigma; PUNC; RIMBP2; ROBO1

ROBO1

Roundabout homolog 1 is a protein that in humans is encoded by the ROBO1 gene.- Function :Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range...

; ROBO2

ROBO2

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.-Further reading:...

; ROBO3

ROBO3

Roundabout homolog 3 is a protein that in humans is encoded by the ROBO3 gene.-Further reading:...

; ROBO4

ROBO4

Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.-Further reading:...

;
ROS1; SDK1; SDK2

SDK2

Protein sidekick-2 is a protein that in humans is encoded by the SDK2 gene.-Further reading:...

; SNED1; SORL1

SORL1

SORL1 is a neuronal apolipoprotein E receptor, the gene for which is predominantly expressed in the central nervous system.-Connection with Alzheimer's disease:...

; SPEG

SPEG

SPEG complex locus, also known as SPEG, is a human gene.Mouse Mutant Alleles for Speg Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the Mutant Mouse Embryonic Stem Cell Clones...

; TEK

TEK tyrosine kinase

Angiopoietin-1 receptor is a protein that in humans is encoded by the TEK gene.TEK has also recently been designated CD202B .-Interactions:...

; TIE1

TIE1

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.- Function :...

;
TNC

Tenascin C

Tenascin is a protein that in humans is encoded by the TNC gene.-Interactions:Tenascin C has been shown to interact with fibronectin.-Further reading:...

; TNN

Tenascin

Tenascins are extracellular matrix glycoproteins. They are abundant in the extracellular matrix of developing vertebrate embryos and they reappear around healing wounds and in the stroma of some tumors.-Types:...

; TNR

Tenascin-R

Tenascin-R is a protein that in humans is encoded by the TNR gene.- Function :Tenascin-R is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin gene family, which includes at least 3 genes in mammals: TNC , TNX , and TNR...

; TNXB; TRIM36; TRIM42; TRIM46; TRIM67;
TRIM9

TRIM9

Tripartite motif-containing protein 9 is a protein that in humans is encoded by the TRIM9 gene.-Further reading:...

; TTN

Titin

Titin , also known as connectin, is a protein that in humans is encoded by the TTN gene. Titin is a giant protein that functions as a molecular spring which is responsible for the passive elasticity of muscle. It is composed of 244 individually folded protein domains connected by unstructured...

; TYRO3

TYRO3

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.-Interactions:TYRO3 has been shown to interact with PIK3R1 and GAS6.-Further reading:...

; UMODL1; USH2A

USH2A

Usherin is a protein that in humans is encoded by the USH2A gene.-External Links:* -Further reading:...

; VASN; VWA1; dJ34F7.1;
fmi

FMI

FMI may refer to:* FMI Corporation* Functional Mock-up Interface* Finnish Meteorological Institute* Food Marketing Institute* International Monetary Fund* Fisheries and Maritime Institute of the College of Micronesia-FSM* Failure Mode Identifier...

;

Human proteins containing this domain

See also