Fecal-oral route
Encyclopedia
The fecal-oral route, or alternatively, the oral-fecal route or orofecal route is a route of transmission
of disease
s, in which they are passed when pathogens in fecal
particles from one host
are introduced into the oral cavity of another potential host.
There are usually intermediate steps, sometimes many of them. Among the more common causes are:
Some of the diseases that can be passed via the fecal-oral route include:
Transmission of Helicobacter pylori
by oral-fecal route has been demonstrated in murine models
.
Transmission (medicine)
In medicine and biology, transmission is the passing of a communicable disease from an infected host individual or group to a conspecific individual or group, regardless of whether the other individual was previously infected...
of disease
Disease
A disease is an abnormal condition affecting the body of an organism. It is often construed to be a medical condition associated with specific symptoms and signs. It may be caused by external factors, such as infectious disease, or it may be caused by internal dysfunctions, such as autoimmune...
s, in which they are passed when pathogens in fecal
Feces
Feces, faeces, or fæces is a waste product from an animal's digestive tract expelled through the anus or cloaca during defecation.-Etymology:...
particles from one host
Host (biology)
In biology, a host is an organism that harbors a parasite, or a mutual or commensal symbiont, typically providing nourishment and shelter. In botany, a host plant is one that supplies food resources and substrate for certain insects or other fauna...
are introduced into the oral cavity of another potential host.
There are usually intermediate steps, sometimes many of them. Among the more common causes are:
- waterWaterWater is a chemical substance with the chemical formula H2O. A water molecule contains one oxygen and two hydrogen atoms connected by covalent bonds. Water is a liquid at ambient conditions, but it often co-exists on Earth with its solid state, ice, and gaseous state . Water also exists in a...
that has come in contact with feces and is then inadequately treatedWater treatmentWater treatment describes those processes used to make water more acceptable for a desired end-use. These can include use as drinking water, industrial processes, medical and many other uses. The goal of all water treatment process is to remove existing contaminants in the water, or reduce the...
before drinking; - foodFoodFood is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals...
that has been handled with feces present; - poor sewage treatmentSewage treatmentSewage treatment, or domestic wastewater treatment, is the process of removing contaminants from wastewater and household sewage, both runoff and domestic. It includes physical, chemical, and biological processes to remove physical, chemical and biological contaminants...
along with disease vectors like housefliesHouseflyThe housefly , Musca domestica, is a fly of the suborder Cyclorrhapha...
; - poor or absent cleaning after handling feces or anything that has been in contact with it;
- sexual practices that may involve feces, such as analingus.
- sexual fetishes that involve feces, known collectively as coprophiliaCoprophiliaCoprophilia , also called scatophilia or scat, is the paraphilia involving sexual pleasure from feces...
(its eating is known as coprophagiaCoprophagiaCoprophagia or coprophagy is the consumption of feces, from the Greek κόπρος copros and φαγεῖν phagein . Many animal species practice coprophagia as a matter of course; other species do not normally consume feces but may do so under unusual conditions...
)
Some of the diseases that can be passed via the fecal-oral route include:
- PoliomyelitisPoliomyelitisPoliomyelitis, often called polio or infantile paralysis, is an acute viral infectious disease spread from person to person, primarily via the fecal-oral route...
- GiardiasisGiardiasisGiardiasis or beaver fever in humans is a diarrheal infection of the small intestine by a single-celled organism Giardia lamblia. Giardiasis occurs worldwide with a prevalence of 20–30% in developing countries. In the U.S., 20,000 cases are reported to the CDC annually, but the true annual...
- Hepatitis AHepatitis AHepatitis A is an acute infectious disease of the liver caused by the hepatitis A virus , an RNA virus, usually spread the fecal-oral route; transmitted person-to-person by ingestion of contaminated food or water or through direct contact with an infectious person...
- Hepatitis EHepatitis EHepatitis E is a viral hepatitis caused by infection with a virus called hepatitis E virus . HEV is a positive-sense single-stranded RNA icosahedral virus with a 7.5 kilobase genome. HEV has a fecal-oral transmission route. It is one of five known hepatitis viruses: A, B, C, D, and E...
- RotavirusRotavirusRotavirus is the most common cause of severe diarrhoea among infants and young children, and is one of several viruses that cause infections often called stomach flu, despite having no relation to influenza. It is a genus of double-stranded RNA virus in the family Reoviridae. By the age of five,...
- ShigellosisShigellosisShigellosis, also known as bacillary dysentery or Marlow Syndrome, in its most severe manifestation, is a foodborne illness caused by infection by bacteria of the genus Shigella. Shigellosis rarely occurs in animals other than humans and other primates like monkeys and chimpanzees...
(bacillary dysentery) - Typhoid feverTyphoid feverTyphoid fever, also known as Typhoid, is a common worldwide bacterial disease, transmitted by the ingestion of food or water contaminated with the feces of an infected person, which contain the bacterium Salmonella enterica, serovar Typhi...
- Vibrio parahaemolyticusVibrio parahaemolyticusVibrio parahaemolyticus is a curved, rod-shaped, Gram-negative bacterium found in brackish saltwater, which, when ingested, causes gastrointestinal illness in humans. V. parahaemolyticus is oxidase positive, facultatively aerobic, and does not form spores...
infections - EnterovirusEnterovirusEnteroviruses are a genus of ssRNA viruses associated with several human and mammalian diseases. Serologic studies have distinguished 66 human enterovirus serotypes on the basis of antibody neutralization tests. Additional antigenic variants have been defined within several of the serotypes on the...
es, including poliomyelitisPoliomyelitisPoliomyelitis, often called polio or infantile paralysis, is an acute viral infectious disease spread from person to person, primarily via the fecal-oral route... - CholeraCholeraCholera is an infection of the small intestine that is caused by the bacterium Vibrio cholerae. The main symptoms are profuse watery diarrhea and vomiting. Transmission occurs primarily by drinking or eating water or food that has been contaminated by the diarrhea of an infected person or the feces...
- Clostridium difficileClostridium difficileClostridium difficile , also known as "CDF/cdf", or "C...
- CryptosporidiosisCryptosporidiosisCryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a protozoan parasite in the phylum Apicomplexa. It affects the intestines of mammals and is typically an acute short-term infection...
- AscariasisAscariasisAscariasis is a human disease caused by the parasitic roundworm Ascaris lumbricoides. Perhaps as many as one quarter of the world's people are infected, with rates of 45% in Latin America and 95% in parts of Africa. Ascariasis is particularly prevalent in tropical regions and in areas of poor...
Transmission of Helicobacter pylori
Helicobacter pylori
Helicobacter pylori , previously named Campylobacter pyloridis, is a Gram-negative, microaerophilic bacterium found in the stomach. It was identified in 1982 by Barry Marshall and Robin Warren, who found that it was present in patients with chronic gastritis and gastric ulcers, conditions that were...
by oral-fecal route has been demonstrated in murine models
Animal model
An animal model is a living, non-human animal used during the research and investigation of human disease, for the purpose of better understanding the disease without the added risk of causing harm to an actual human being during the process...
.