Estrogen related receptor
Encyclopedia
There are three known estrogen
related receptors:
The ERRs are members of the orphan nuclear receptor
family.
ERR's bind to estrogen response elements on DNA
and modulate transcription
but do not bind to endogenous estrogens.
In addition, ERR's seem to have their own response elements termed ERRE's. ERR's have been shown to play a role in energy homeostasis and cancer
.
Estrogen
Estrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal...
related receptors:
- ERRαEstrogen-related receptor alphaEstrogen-related receptor alpha , also known as NR3B1 , is a nuclear receptor that in humans is encoded by the ESRRA gene.-Tissue distribution:...
- ERRβEstrogen-related receptor betaEstrogen-related receptor beta , also known as NR3B2 , is a nuclear receptor that in humans is encoded by the ESRRB gene .- Function :...
- ERRγEstrogen-related receptor gammaEstrogen-related receptor gamma , also known as NR3B3 , is a nuclear receptor that in humans is encoded by the ESRRG gene. It behaves as a constitutive activator of transcription.This protein is a member of nuclear hormone receptor family of steroid hormone receptors...
The ERRs are members of the orphan nuclear receptor
Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...
family.
ERR's bind to estrogen response elements on DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
and modulate transcription
Transcription (genetics)
Transcription is the process of creating a complementary RNA copy of a sequence of DNA. Both RNA and DNA are nucleic acids, which use base pairs of nucleotides as a complementary language that can be converted back and forth from DNA to RNA by the action of the correct enzymes...
but do not bind to endogenous estrogens.
In addition, ERR's seem to have their own response elements termed ERRE's. ERR's have been shown to play a role in energy homeostasis and cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
.