Epipodophyllotoxin
Encyclopedia
Epipodophyllotoxins are alkaloids naturally occurring in the root of American Mayapple plant (Podophyllum peltatum).
Some epipodophyllotoxin derivatives are currently used in the treatment of cancer
. These include etoposide
and teniposide
. They act as anti-cancer drugs by inhibiting topoisomerase II.
Some epipodophyllotoxin derivatives are currently used in the treatment of cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
. These include etoposide
Etoposide
Etoposide phosphate is an anti-cancer agent. It is known in the laboratory as a topoisomerase poison. Etoposide is often incorrectly referred to as a topoisomerase inhibitor in order to avoid using the term "poison" in a clinical setting...
and teniposide
Teniposide
Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia . It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body....
. They act as anti-cancer drugs by inhibiting topoisomerase II.