ETV6
Encyclopedia
ETV6 is an oncogene
.
with Grb2
, FLI1
and HTATIP
.
Oncogene
An oncogene is a gene that has the potential to cause cancer. In tumor cells, they are often mutated or expressed at high levels.An oncogene is a gene found in the chromosomes of tumor cells whose activation is associated with the initial and continuing conversion of normal cells into cancer...
.
Interactions
ETV6 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Grb2
Grb2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene....
, FLI1
FLI1
Friend leukemia integration 1 transcription factor , also known as proto-oncogene Fli-1 or transcription factor ERGB, is a protein that in humans is encoded by the human FLI1 gene. - Function :...
and HTATIP
HTATIP
Histone acetyltransferase KAT5 is an enzyme that in humans is encoded by the KAT5 gene.- Function :The protein encoded by this gene belongs to the MYST family of histone acetyl transferases and was originally isolated as an HIV-1 TAT-interactive protein...
.
See also
- TEL-JAK2TEL-JAK2TEL-JAK2 is a gene fusion resulting from a chromosomal translocation between chromosomes 9 and 12 observed in human leukemia . The 5' moiety of TEL is fused to the 3' end of JAK2....
| Mouse Mutant Alleles for Etv6 | ||
|---|---|---|
| Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI | Etv6 | |
| Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. | Etv6tm1a(KOMP)Wtsi | |
| Example structure of targeted conditional mutant allele for this gene | ||
wtsi.jpg) | ||
| These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Etv6: see Knockout mouse Knockout mouse A knockout mouse is a genetically engineered mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA... | ||