Dysgammaglobulinemia
Encyclopedia
Dysgammaglobulinemia is a type of immune disorder
characterized by a reduction in some types of gamma globulin
s.
It is distinguished from hypogammaglobulinemia
, which is a reduction in all types of gamma globulins.
Hyper IgM syndrome
can be considered a form of dysgammaglobulinemia, because it results from a failure of transformation from IgM
production to production of other antibodies, and so the condition can be interpreted as a reduction of the other types.
Immune disorder
An immune disorder is a dysfunction of the immune system. These disorders can be characterized in several different ways:* By the component of the immune system affected* By whether the immune system is overactive or underactive...
characterized by a reduction in some types of gamma globulin
Gamma globulin
Gamma globulins are a class of globulins, identified by their position after serum protein electrophoresis. The most significant gamma globulins are immunoglobulins , more commonly known as antibodies, although some Igs are not gamma globulins, and some gamma globulins are not Igs.-Use as medical...
s.
It is distinguished from hypogammaglobulinemia
Hypogammaglobulinemia
Hypogammaglobulinemia is a type of immune disorder characterized by a reduction in all types of gamma globulins.Hypogammaglobulinemia is a characteristic of common variable immunodeficiency.-Terminology:...
, which is a reduction in all types of gamma globulins.
Hyper IgM syndrome
Hyper IgM syndrome
Hyper IgM syndrome is a family of genetic disorders in which the level of Immunoglobulin M antibodies is relatively high. The most common type is a result of a defect in a Th2 cell protein . The disorder causes immunodeficiencies, including a higher than normal susceptibility to various types of...
can be considered a form of dysgammaglobulinemia, because it results from a failure of transformation from IgM
IGM
IGM as an acronym or abbreviation can refer to:* Immunoglobulin M , the primary antibody against A and B antigens on red blood cells* International Grandmaster, a chess ranking* intergalactic medium* Intragroup medium - see: Intracluster medium...
production to production of other antibodies, and so the condition can be interpreted as a reduction of the other types.
External links
- Raif S. Geha et al.: "Hyper Immunoglobulin M Immunodeficiency (Dysgammaglobulinemia)", Journal of Clinical Investigation, 1979 August; 64(2): 385–391, doi: 10.1172/JCI109473. Accessed 2009-07-17.
- Andre Cruchaud et al.: "The site of synthesis of the 19S T-globulins in dysgammaglobulinemia" (1962). Accessed 2009-07-17.