Diablo homolog, mitochondrial is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the DIABLO gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

 (direct IAP binding protein with low pI). DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC.

Function

SMAC is a mitochondrial protein that promotes cytochrome-c dependent activation by eliminating the inhibition via IAP - a protein that negatively regulates apoptosis

Apoptosis

Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...

 or programmed cell death. Smac is normally a mitochondrial protein but is found in the cytosol when a cell is primed for apoptosis by the final execution step of caspase

Caspase

Caspases, or cysteine-aspartic proteases or cysteine-dependent aspartate-directed proteases are a family of cysteine proteases that play essential roles in apoptosis , necrosis, and inflammation....

 activation. Smac is the second protein in the apoptosis link, along with cytochrome c, that promotes apoptosis by activating caspases.

SMAC is an inhibitor of apoptosis protein (IAP)-binding protein. This mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs.

Gene

Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively.

Interactions

Diablo homolog has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Lymphotoxin beta receptor

Lymphotoxin beta receptor

Lymphotoxin beta receptor is a receptor for lymphotoxin which in humans is encoded by the LTBR gene.-Function:The protein encoded by this gene is a member of the tumor necrosis factor family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid...

, Survivin

Survivin

Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene....

, XIAP

XIAP

X-linked inhibitor of apoptosis protein also known as inhibitor of apoptosis protein 3 and baculoviral IAP repeat-containing protein 4 is a protein that in humans is encoded by the XIAP gene....

 and BIRC2

BIRC2

Baculoviral IAP repeat-containing protein 2 is a protein that in humans is encoded by the BIRC2 gene.-Interactions:...

.

Further reading