DSN1
Encyclopedia
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein
which in humans encoded by the DSN1 gene
.
, DC8
, PMF1, CBX5
, ZWINT
is a component of the kinetochore
-associated multiprotein complex which is required for correct chromosome alignment during the metaphase
of cell mitosis
.
with NSL1
and MIS12
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
which in humans encoded by the DSN1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
DSN1 along with MIS12MIS12
Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.-Interactions:MIS12 has been shown to interact with NSL1, ZWINT, CASC5, Polyamine-modulated factor 1, NDC80, DSN1 and CBX5.-Further reading:...
, DC8
NSL1
Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.-Interactions:NSL1 has been shown to interact with MIS12 and DSN1.-Further reading:...
, PMF1, CBX5
CBX5 (gene)
Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene.-Interactions:CBX5 has been shown to interact with HDAC9, Ku70, MIS12, Lamin B receptor, MBD1, TAF4, Histone deacetylase 5, TRIM28, HDAC4, CBX3, SMARCA4, DNMT3B, CHAF1A, CBX1 and SUV39H1....
, ZWINT
ZWINT
ZW10 interactor is a protein that in humans is encoded by the ZWINT gene.- Function :Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores...
is a component of the kinetochore
Kinetochore
The kinetochore is the protein structure on chromatids where the spindle fibers attach during cell division to pull sister chromatids apart....
-associated multiprotein complex which is required for correct chromosome alignment during the metaphase
Metaphase
Metaphase, from the ancient Greek μετά and φάσις , is a stage of mitosis in the eukaryotic cell cycle in which condensed & highly coiled chromosomes, carrying genetic information, align in the middle of the cell before being separated into each of the two daughter cells...
of cell mitosis
Mitosis
Mitosis is the process by which a eukaryotic cell separates the chromosomes in its cell nucleus into two identical sets, in two separate nuclei. It is generally followed immediately by cytokinesis, which divides the nuclei, cytoplasm, organelles and cell membrane into two cells containing roughly...
.
Interactions
DSN1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NSL1
NSL1
Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.-Interactions:NSL1 has been shown to interact with MIS12 and DSN1.-Further reading:...
and MIS12
MIS12
Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.-Interactions:MIS12 has been shown to interact with NSL1, ZWINT, CASC5, Polyamine-modulated factor 1, NDC80, DSN1 and CBX5.-Further reading:...
.