DOCK is a family of related proteins involved in intracellular

Intracellular

Not to be confused with intercellular, meaning "between cells".In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".It is used in contrast to extracellular...

 signalling networks. Studies to date suggest that this family act as guanine nucleotide exchange factors for small G proteins of the Rho family, such as Rac

Rac (GTPase)

Rac is a subfamily of the Rho family of GTPases, small signaling G proteins .The subgroup include:*Rac1*Rac2*Rac3*RhoG...

 and Cdc42

CDC42

Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.- Function :...

. DOCK family proteins are categorised into four subfamilies based on their sequence homology:

• DOCK-A subfamily
  • Dock180 (also known as Dock1)
  • Dock2
    DOCK2
    Dock2 , also known as DOCK2, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins...
    
    
  • Dock5
    Dock5
    Dock5 , also known as DOCK5, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins...
    
    
• DOCK-B subfamily
  • Dock3
    DOCK3
    Dock3 , also known as MOCA and PBP , is a large protein involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins...
    
     (also known as MOCA and PBP)
  • Dock4
    DOCK4
    Dock4, also known as DOCK4, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins...
    
    
• DOCK-C subfamily (also known as Zir subfamily)
  • Dock6
    Dock6
    Dock6 , also known as Zir1 is a large protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins.-Discovery:Dock6 was identified as one of a family of...
    
     (also known as Zir1)
  • Dock7
    DOCK7
    Dock7 , also known as Zir2, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins...
    
     (also known as Zir2)
  • Dock8
    DOCK8
    Dock8 , also known as Zir3, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins.-Discovery:Dock8 was identified during a yeast two hybrid...
    
     (also known as Zir3)
• DOCK-D subfamily (also known as Zizimin subfamily)
  • Dock9
    DOCK9
    Dock9 , also known as Zizimin1, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins...
    
     (also known as Zizimin1)
  • Dock10
    DOCK10
    Dock10 , also known as Zizimin3, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins.-Discovery:Dock10 was identified via bioinformatic...
    
     (also known as Zizimin3)
  • Dock11
    Dock11
    Dock11 , also known as Zizimin2, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins...
    
    (also known as Zizimin2)