DMCM
Encyclopedia
DMCM is a drug from the beta-carboline
family. It acts as an inverse agonist
of benzodiazepine receptors, meaning that it causes the opposite effects to the benzodiazepine
class of drugs. As such, DMCM has anxiogenic
and convulsant
properties, and is used in scientific research to induce anxiety so that new anxiolytic
medications can be tested, and to produce convulsions so that anticonvulsant
medications can be tested. It has also been shown to produce analgesic
effects in animals, thought to be because it produces panic
which reduces the perception of pain.
Beta-carboline
β-Carboline is an organic amine that is the prototype of a class of compounds known as β-carbolines.-Pharmacology:...
family. It acts as an inverse agonist
Inverse agonist
In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist....
of benzodiazepine receptors, meaning that it causes the opposite effects to the benzodiazepine
Benzodiazepine
A benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...
class of drugs. As such, DMCM has anxiogenic
Anxiogenic
An anxiogenic substance is one that causes anxiety. Anxiogenic effects can be measured by, for example, the hole-board test in rats and mice. A number of agents are used to provoke anxiety or panic in experimental models...
and convulsant
Convulsant
A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs generally act as stimulants at low doses, but are not used for this purpose due to the risk of convulsions and consequent excitotoxicity...
properties, and is used in scientific research to induce anxiety so that new anxiolytic
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...
medications can be tested, and to produce convulsions so that anticonvulsant
Anticonvulsant
The anticonvulsants are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and in the treatment of neuropathic pain. The goal of an...
medications can be tested. It has also been shown to produce analgesic
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
effects in animals, thought to be because it produces panic
Panic
Panic is a sudden sensation of fear which is so strong as to dominate or prevent reason and logical thinking, replacing it with overwhelming feelings of anxiety and frantic agitation consistent with an animalistic fight-or-flight reaction...
which reduces the perception of pain.