The term cryosupernatant (also called cryo-poor plasma, cryoprecipitate depleted) refers to plasma

Blood plasma

Blood plasma is the straw-colored liquid component of blood in which the blood cells in whole blood are normally suspended. It makes up about 55% of the total blood volume. It is the intravascular fluid part of extracellular fluid...

 from which the cryoprecipitate

Cryoprecipitate

Cryoprecipitate, also called "Cryoprecipitated Antihemophilic Factor", "Cryoprecipitated AHF", and most commonly just "cryo", is a frozen blood product prepared from plasma.It is often transfused as a four to six unit pool instead of as a single product...

 has been removed.

Components

The resulting plasma has reduced levels of Factor VIII

Factor VIII

Factor VIII is an essential blood clotting factor also known as anti-hemophilic factor . In humans, Factor VIII is encoded by the F8 gene...

 (FVIII), von Willebrand factor

Von Willebrand factor

von Willebrand factor is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome...

 (VWF), Factor XIII

Factor XIII

Factor XIII or fibrin stabilizing factor is an enzyme of the blood coagulation system that crosslinks fibrin.- Function :Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier B subunits...

 (FXIII), fibronectin

Fibronectin

Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin and heparan sulfate proteoglycans...

 and fibrinogen

Fibrinogen

Fibrinogen is a soluble plasma glycoprotein, synthesised by the liver, that is converted by thrombin into fibrin during blood coagulation. This is achieved through processes in the coagulation cascade that activate the zymogen prothrombin to the serine protease thrombin, which is responsible for...

. While the levels of FVIII are greatly reduced, levels of fibrinogen can be as much as 70% of original levels.

Uses

Cryosupernatant plasma can be used when replacement of FVIII is not required, and is indicated for plasma exchange for patients with thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura is a rare disorder of the blood-coagulation system, causing extensive microscopic thromboses to form in small blood vessels throughout the body...

 (TTP) as well as for treatment of hemolytic-uremic syndrome

Hemolytic-uremic syndrome

Hemolytic-uremic syndrome , abbreviated HUS, is a disease characterized by hemolytic anemia, acute renal failure and a low platelet count . It predominantly, but not exclusively, affects children. Most cases are preceded by an episode of diarrhea caused by E. coli O157:H7, which is acquired as a...

(HUS) by plasma exchange, when plasma exchange is indicated.