Contact inhibition
Encyclopedia
Contact inhibition is the natural process of arresting cell growth
when two or more cells come into contact with each other. Oncologists use this property to distinguish between normal and cancerous cells.
Cell lines used widely in animal cell culture
laboratories are genetically modified to suppress apoptosis
however maintain this phenomenon. Therefore, cells are cancerous however their proliferation could be controlled when present in low serum levels or when in contact with neighbouring cells (i.e. contact inhibition).
In tissue culture laboratories cells growing on T25 and T75 flasks need constant replacements to maintain their normal cell numbers otherwise cells would display contact inhibition and therefore, die as a result.
Cancer
ous cells typically lose this property and thus grow in an uncontrolled manner even when in contact with neighbouring cells. Cells of naked mole rat
s, a species in which cancer has never been observed, show hypersensitivity to contact inhibition.
Cell growth
The term cell growth is used in the contexts of cell development and cell division . When used in the context of cell division, it refers to growth of cell populations, where one cell grows and divides to produce two "daughter cells"...
when two or more cells come into contact with each other. Oncologists use this property to distinguish between normal and cancerous cells.
Cell lines used widely in animal cell culture
Cell culture
Cell culture is the complex process by which cells are grown under controlled conditions. In practice, the term "cell culture" has come to refer to the culturing of cells derived from singlecellular eukaryotes, especially animal cells. However, there are also cultures of plants, fungi and microbes,...
laboratories are genetically modified to suppress apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
however maintain this phenomenon. Therefore, cells are cancerous however their proliferation could be controlled when present in low serum levels or when in contact with neighbouring cells (i.e. contact inhibition).
In tissue culture laboratories cells growing on T25 and T75 flasks need constant replacements to maintain their normal cell numbers otherwise cells would display contact inhibition and therefore, die as a result.
Cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
ous cells typically lose this property and thus grow in an uncontrolled manner even when in contact with neighbouring cells. Cells of naked mole rat
Naked Mole Rat
The naked mole rat , also known as the sand puppy or desert mole rat, is a burrowing rodent native to parts of East Africa and the only species currently classified in the genus Heterocephalus...
s, a species in which cancer has never been observed, show hypersensitivity to contact inhibition.