Cladinose
Encyclopedia
Cladinose is a hexose
deoxy sugar
that in several antibiotics (such as erythromycin
) is attached to the macrolide
ring.
In ketolides
, a relatively new class of antibiotics, the cladinose is replaced with a keto
group.
Hexose
In organic chemistry, a hexose is a monosaccharide with six carbon atoms, having the chemical formula C6H12O6. Hexoses are classified by functional group, with aldohexoses having an aldehyde at position 1, and ketohexoses having a ketone at position 2....
deoxy sugar
Deoxy sugar
Deoxy sugars are sugars that have had a hydroxyl group replaced with a hydrogen atom.Examples include:* Deoxyribose * Fucose* Rhamnose-External links:*...
that in several antibiotics (such as erythromycin
Erythromycin
Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma and...
) is attached to the macrolide
Macrolide
The macrolides are a group of drugs whose activity stems from the presence of a macrolide ring, a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered...
ring.
In ketolides
Ketolides
Ketolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. These modifications give ketolides much broader spectrum than other macrolides...
, a relatively new class of antibiotics, the cladinose is replaced with a keto
Keto
Keto can refer to:* The Keto people, an ethnic group of the Siberian North.* Ceto or Keto, a sea goddess in Greek mythology.* Ketone or keto group, the functional group in the chemical compounds ketones....
group.
