Carboxylesterase family
Encyclopedia
Carboxylesterase, type B is a family of evolutionarily related proteins
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Higher eukaryotes have many distinct esterase
s. Among the different types are those which act on carboxylic esters . Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates that the majority are evolutionarily related. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. This family belongs to the superfamily of proteins with the Alpha/beta hydrolase fold
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Protein family
A protein family is a group of evolutionarily-related proteins, and is often nearly synonymous with gene family. The term protein family should not be confused with family as it is used in taxonomy....
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Higher eukaryotes have many distinct esterase
Esterase
An esterase is a hydrolase enzyme that splits esters into an acid and an alcohol in a chemical reaction with water called hydrolysis.A wide range of different esterases exist that differ in their substrate specificity, their protein structure, and their biological function.- EC classification/list...
s. Among the different types are those which act on carboxylic esters . Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates that the majority are evolutionarily related. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. This family belongs to the superfamily of proteins with the Alpha/beta hydrolase fold
Alpha/beta hydrolase fold
In molecular biology, the alpha/beta hydrolase fold is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is an alpha/beta-sheet , containing 8 strands connected byhelices...
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Examples
Human genes that encode proteins containing the carboxylesterase domain include:- ACHEAcheAche may refer to:* Ache, a chronic, painful sensation* Ache , a You've Got Foetus on Your Breath album* "Ache" , a song by No Doubt* Ache Records, a Vancouver-based record label* The American College of Healthcare Executives...
- ARACHE
- BCHE
- CELCELCEL may stand for:*Carboxyl ester lipase or bile salt dependent lipase, an enzyme used in digestion*Check engine light, a malfunction indicator lamp*Chemin de Fer de l'Etat Libanais, the national railway network of the Lebanon...
- CES1
- CES2
- CES3
- CES4
- CES7
- CES8
- NLGN1NLGN1Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.-Interactions:NLGN1 has been shown to interact with NRXN1 and DLG4.-Further reading:...
- NLGN2NLGN2Neuroligin-2 is a protein that in humans is encoded by the NLGN2 gene.-Further reading:...
- NLGN3NLGN3Neuroligin-3 is a protein that in humans is encoded by the NLGN3 gene.-Further reading:...
- NLGN4XNLGN4XNeuroligin-4, X-linked is a protein that in humans is encoded by the NLGN4X gene.-Further reading:...
- NLGN4Y
- TGThyroglobulinThyroglobulin is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as colloid....
External links
- Carboxylesterases type-B in PROSITEPROSITEPROSITE is a protein database. It consists of entries describing the protein families, domains and functional sites as well as amino acid patterns, signatures, and profiles in them. These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot...