CTBP1
Encyclopedia
C-terminal-binding protein 1 also known as CtBP1 is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the CTBP1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

The CtBP1 protein binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein
Phosphoprotein
Phosphoproteins are proteins that are physically bonded to a substance containing phosphoric acid . This category of organic molecules includes Fc receptors, Ulks, Calcineurins, K chips, and urocortins....

 is a transcriptional repressor (corepressor) and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2
CTBP2
C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.- Function :This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor , while the other isoform is a major component of specialized...

, can dimerize. CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of δEF1, a cellular zinc finger-homeodomain protein, and thereby enhances δEF1-induced transcriptional silencing. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

Interactions

CTBP1 has been shown to interact
Protein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with:
  • ACTL6B
    ACTL6B
    Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.-Further reading:...

    ,
  • ARF
    ARF
    -Organizations:* Advertising Research Foundation* Animal Rescue Foundation* Animal Rights Federation, an animal rights advocacy organization* Armenian Revolutionary Federation* Armtec Infrastructur Co.'s ticker symbol as of 2011...

    ,
  • EVI1
    EVI1
    MDS1 and EVI1 complex locus protein EVI1 also known as ecotropic virus integration site 1 protein homolog or positive regulatory domain zinc finger protein 3 is a protein that in humans is encoded by the MECOM gene. EVI1 was first identified as a common retroviral integration site in AKXD murine...

  • FOXP2
    FOXP2
    Forkhead box protein P2 also known as FOXP2 is a protein that in humans is encoded by the FOXP2 gene, located on human chromosome 7 . FOXP2 orthologs have also been identified in all mammals for which complete genome data are available...

    ,
  • HDAC1
    HDAC1
    Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.-Interactions:HDAC1 has been shown to interact with RAD9A, DNMT3L, MTA1, FKBP3, CDC20, CDH1, Host cell factor C1, BUB3, Nuclear receptor co-repressor 2, IKZF1, Prohibitin, EVI1, DDX5, DNMT3A, Mothers against...

    ,
  • IKZF1
    IKZF1
    DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene. Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia...

    ,
  • IKZF4
    IKZF4
    Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.-Interactions:IKZF4 has been shown to interact with CTBP1 and IKZF1.-Further reading:...

    ,
  • Mdm2
    Mdm2
    Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain of the p53 tumor suppressor and an inhibitor of...

    ,
  • MLL
    MLL (gene)
    Histone-lysine N-methyltransferase HRX is an enzyme that in humans is encoded by the MLL gene.MLL is a histone methyltransferase deemed a positive global regulator of gene transcription...

    ,
  • NRIP1
    NRIP1
    Nuclear receptor-interacting protein 1 is a protein that in humans is encoded by the NRIP1 gene.RIP140 has an important role in regulating lipid and glucose metabolism, and regulates gene expression in metabolic tissues including heart, skeletal muscle, and liver.Knockout mice that completely lack...

    ,
  • Pinin
    Pinin
    Pinin is a protein that in humans is encoded by the PNN gene.-Interactions:Pinin has been shown to interact with Keratin 8, Keratin 18, Keratin 19, CTBP1, RNPS1, PRPF4B, SFRS4, PPIG, SRRM2 and SFRS18.-Further reading:...

    ,
  • RBBP8
    RBBP8
    Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.-Interactions:RBBP8 has been shown to interact with LMO4, Retinoblastoma-like protein 2, Retinoblastoma-like protein 1, Ataxia telangiectasia mutated, Retinoblastoma protein, CTBP1, SIAH1 and BRCA1.-Further...

    , and
  • TGIF1
    Homeobox protein TGIF1
    Homeobox protein TGIF1 is a protein that in humans is encoded by the TGIF1 gene. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.- Function :...

    .


Further reading

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