CRMP1
Encyclopedia
Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein
of the CRMP family
.
This gene encodes a member of a family of cytosol
ic phosphoprotein
s expressed exclusively in the nervous system
. The encoded protein is thought to be a part of the semaphorin
signal transduction pathway implicated in semaphorin-induced growth cone
collapse during neural development
. Alternative splicing
results in multiple transcript variants.
CRMP1 mediates reelin
signaling in cortical neuronal migration. Mice deficient in CRMP1 exhibit impaired long-term potentiation
and impaired spatial learning
and memory
.
CRMP1 gene overlaps with another gene called EVC
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
of the CRMP family
Collapsin response mediator protein family
Collapsin response mediator protein family or CRMP family consists of five intracellular phosphoproteins of similar molecular size and high amino acid sequence identity. CRMPs are predominantly expressed in the nervous system during development and are parts to the mechanism underlying the...
.
This gene encodes a member of a family of cytosol
Cytosol
The cytosol or intracellular fluid is the liquid found inside cells, that is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondrion into compartments....
ic phosphoprotein
Phosphoprotein
Phosphoproteins are proteins that are physically bonded to a substance containing phosphoric acid . This category of organic molecules includes Fc receptors, Ulks, Calcineurins, K chips, and urocortins....
s expressed exclusively in the nervous system
Nervous system
The nervous system is an organ system containing a network of specialized cells called neurons that coordinate the actions of an animal and transmit signals between different parts of its body. In most animals the nervous system consists of two parts, central and peripheral. The central nervous...
. The encoded protein is thought to be a part of the semaphorin
Semaphorin
Semaphorins are a class of secreted and membrane proteins that act as axonal growth cone guidance molecules. They primarily act as short-range inhibitory signals and signal through multimeric receptor complexes. They are usually cues to deflect axons from inappropriate regions, especially...
signal transduction pathway implicated in semaphorin-induced growth cone
Growth cone
A growth cone is a dynamic, actin-supported extension of a developing axon seeking its synaptic target. Their existence was originally proposed by Spanish histologist Santiago Ramón y Cajal based upon stationary images he observed under the microscope...
collapse during neural development
Neural development
Neural development comprises the processes that generate, shape, and reshape the nervous system, from the earliest stages of embryogenesis to the final years of life. The study of neural development aims to describe the cellular basis of brain development and to address the underlying mechanisms...
. Alternative splicing
Alternative splicing
Alternative splicing is a process by which the exons of the RNA produced by transcription of a gene are reconnected in multiple ways during RNA splicing...
results in multiple transcript variants.
CRMP1 mediates reelin
Reelin
Reelin is a large secreted extracellular matrix protein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the...
signaling in cortical neuronal migration. Mice deficient in CRMP1 exhibit impaired long-term potentiation
Long-term potentiation
In neuroscience, long-term potentiation is a long-lasting enhancement in signal transmission between two neurons that results from stimulating them synchronously. It is one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength...
and impaired spatial learning
Learning
Learning is acquiring new or modifying existing knowledge, behaviors, skills, values, or preferences and may involve synthesizing different types of information. The ability to learn is possessed by humans, animals and some machines. Progress over time tends to follow learning curves.Human learning...
and memory
Memory
In psychology, memory is an organism's ability to store, retain, and recall information and experiences. Traditional studies of memory began in the fields of philosophy, including techniques of artificially enhancing memory....
.
CRMP1 gene overlaps with another gene called EVC
EVC (gene)
EVC is a gene associated with Ellis-van Creveld syndrome. It overlaps with the CRMP1 gene....
.